{"id":7452,"date":"2013-06-17T07:42:45","date_gmt":"2013-06-17T07:42:45","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/las-celulas-ljuegan-al-pilla-pillar-para-determinar-la-direccion-de-su-movimiento-durante-el-desarrollo-embrionario\/"},"modified":"2015-01-07T13:05:11","modified_gmt":"2015-01-07T13:05:11","slug":"las-celulas-ljuegan-al-pilla-pillar-para-determinar-la-direccion-de-su-movimiento-durante-el-desarrollo-embrionario","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/las-celulas-ljuegan-al-pilla-pillar-para-determinar-la-direccion-de-su-movimiento-durante-el-desarrollo-embrionario\/","title":{"rendered":"Las c\u00e9lulas \u00abjuegan al pilla-pilla\u00bb para determinar la direcci\u00f3n de su movimiento durante el desarrollo embrionario"},"content":{"rendered":"

Cient\u00edficos del IBEC y la Facultad de Medicina de la UB, junto con investigadores del King\u2019s College y el University College de Londres, han examinado las c\u00e9lulas de la cresta neural, una estructura embrionaria de los vertebrados formada por c\u00e9lulas migratorias que generan las c\u00e9lulas del sistema nervioso perif\u00e9rico y otros tipos de c\u00e9lulas del sistema cardiovascular, as\u00ed como las c\u00e9lulas pigmentarias de la piel y gran parte del tejido conectivo de la cabeza, los huesos y los cart\u00edlagos. Los investigadores observaron que, durante su desarrollo, las c\u00e9lulas de la cresta neural \u00abpersiguen\u00bb a otros tipos de c\u00e9lulas, las de las placodas, l\u00e1minas que forman los \u00f3rganos sensoriales, y que huyen a su vez cuando est\u00e1n a punto de ser alcanzadas. Esta persecuci\u00f3n da lugar a un movimiento direccional y coordinado necesario para el correcto desarrollo embrionario.<\/p>\n

Seg\u00fan Xavier Trepat, investigador ICREA de la UB y del IBEC, \u00abes como un asno que persigue una zanahoria: las c\u00e9lulas de la cresta neural son el asno que persigue pero nunca alcanza la zanahoria, las c\u00e9lulas de las placodas\u00bb. \u00abLa \u201cpersecuci\u00f3n\u201d se produce en presencia de una prote\u00edna de se\u00f1alizaci\u00f3n, la Sdf1, mientras que la \u201chuida\u201d la provoca otra prote\u00edna, la N-cadherina\u00bb, a\u00f1ade Trepat.<\/p>\n

Los resultados de la investigaci\u00f3n aportan nuevos datos sobre el proceso de la migraci\u00f3n celular, esencial en el desarrollo y la regeneraci\u00f3n de tejidos. Entender mejor el funcionamiento de la migraci\u00f3n celular permitir\u00eda conocer mejor los mecanismos por los cuales las c\u00e9lulas cancerosas invaden los tejidos vecinos.<\/p>\n

Trayectorias de las c\u00e9lulas de la cresta neural (en azul), que persiguen a las de las placodas (en p\u00farpura). (\u00a9 UCL)<\/p>\n

—<\/p>\n

E Theveneau, B Steventon, E Scarpa, S Garcia, X Trepat, A Streit & R Mayor (2013). ‘Chase-and-run between adjacent cell populations promotes directional collective migration<\/a>‘. Nature Cell Biology, doi:10.1038\/ncb2772<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y la Universidad de Barcelona han estudiado el proceso de migraci\u00f3n celular colectiva en el que las c\u00e9lulas realizan movimientos sincronizados en una direcci\u00f3n particular.<\/h3>\n

Sorprendentemente, los investigadores descubrieron que estos movimientos son parecidos al juego del pilla-pilla.<\/p>\n","protected":false},"author":4,"featured_media":7447,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-7452","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nLas c\u00e9lulas \u00abjuegan al pilla-pilla\u00bb para determinar la direcci\u00f3n de su movimiento durante el desarrollo embrionario - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/las-celulas-ljuegan-al-pilla-pillar-para-determinar-la-direccion-de-su-movimiento-durante-el-desarrollo-embrionario\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Las c\u00e9lulas \u00abjuegan al pilla-pilla\u00bb para determinar la direcci\u00f3n de su movimiento durante el desarrollo embrionario - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y la Universidad de Barcelona han estudiado el proceso de migraci\u00f3n celular colectiva en el que las c\u00e9lulas realizan movimientos sincronizados en una direcci\u00f3n particular. 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