{"id":74697,"date":"2020-06-02T18:13:43","date_gmt":"2020-06-02T16:13:43","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new-chemical-lego-blocks-for-health-solutions\/"},"modified":"2020-06-15T12:54:22","modified_gmt":"2020-06-15T10:54:22","slug":"new-chemical-lego-blocks-for-health-solutions","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/new-chemical-lego-blocks-for-health-solutions\/","title":{"rendered":"Nuevos bloques qu\u00edmicos tipo \u00ablego\u00bb para soluciones de salud"},"content":{"rendered":"

Dentro de este grupo, Edgar y sus colegas se centran en la s\u00edntesis de nuevos materiales supramoleculares inteligentes para la administraci\u00f3n de medicamentos.<\/p>\n

Hace m\u00e1s de un a\u00f1o, el Grupo de Albertazzi en el IBEC comenz\u00f3 una fruct\u00edfera colaboraci\u00f3n con el Grupo de Ilja Voets en el ICMS<\/a>, en la Universidad T\u00e9cnica de Eindhoven. Pero no solo esto, otros dos grupos de expertos se unieron a esta colaboraci\u00f3n: el grupo de Nanosondas y Nanocommutadores<\/a> dirigido por Pau Gorostiza en el IBEC y el grupo de \u00abQu\u00edmica de pol\u00edmeros y Materiales\u00bb dirigido por Jos\u00e9 Berrocal en el Adolphe Merkle Institute en Suiza. Como resultado de este gran equipo, los investigadores han publicado recientemente un art\u00edculo destacado en el Journal of the American Society of Chemistry (JACS).<\/p>\n

La mol\u00e9cula en forma de disco, se sintetiz\u00f3 en Barcelona y se le incorpor\u00f3 una parte pept\u00eddica hecha de lisina (sensible al pH), una cadena de octaetilenglicol sensible a la temperatura y una parte de azobenceno que responde a los est\u00edmulos de luz. Los investigadores observan que al combinar estas partes en una sola mol\u00e9cula, el compuesto final mantiene la capacidad de respuesta, cambiando su carga y su forma. Y, lo que es a\u00fan m\u00e1s fascinante, estos cambios pueden promover que las mol\u00e9culas en forma de disco se apilen una encima de la otra formando una pila de mol\u00e9culas.<\/p>\n

Seg\u00fan los investigadores: \u201cNuestro sistema responde de manera controlada y reversible a la luz, la temperatura, el pH y la fuerza i\u00f3nica, modulando el equilibrio de ensamblaje y desmontaje. Esto es especialmente interesante para aplicaciones biol\u00f3gicas, como la administraci\u00f3n de f\u00e1rmacos o la ingenier\u00eda de tejidos, donde controlar el rendimiento del material en un entorno complejo es todo un desaf\u00edo<\/strong>\u201d. Edgar Fuentes, primer autor del art\u00edculo pas\u00f3 una semana en Eindhoven, trabajando directamente con el Grupo Voets, gracias al acuerdo de colaboraci\u00f3n IBEC-ICMS<\/a> explica la importancia del hallazgo de una manera muy integral:<\/p>\n

Hemos desarrollado unas \u00abpiezas de lego\u00bb muy peque\u00f1as que se comportan como un interruptor capaz de cambiar con la luz u otras condiciones ambientales. Pero lo m\u00e1s fascinante es lo siguiente: bajo ciertas condiciones, estas peque\u00f1as piezas pueden interactuar espont\u00e1neamente con muchas otras piezas, formando objetos similares a fibras en el agua, 10000 veces m\u00e1s delgadas que un cabello.<\/strong><\/p>\n

Edgar Fuentes, primer autor del art\u00edculo<\/em><\/strong><\/p><\/blockquote>\n

\n

Art\u00edculo de referencia: <\/strong>Fuentes, M. Gerth, J. A. Berrocal, C. Matera, P. Gorostiza, I. K. Voets, S. Pujals and L. Albertazzi. An Azobenzene-Based Single-Component Supramolecular Polymer Responsive to Multiple Stimuli in Water.<\/a> JACS, 2020.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Investigadores del IBEC desarrollan nuevas mol\u00e9culas de respuesta m\u00faltiple capaces de autoensamblarse en el agua formando estructuras fibrosas. Las llamadas mol\u00e9culas disc\u00f3ticas muestran sensibilidad a la temperatura, la luz, el pH y la fuerza i\u00f3nica y pueden mostrar un gran potencial para aplicaciones m\u00e9dicas como sistemas de administraci\u00f3n de medicamentos, diagn\u00f3stico o ingenier\u00eda de tejidos.<\/h3>\n

Edgar Fuentes es un estudiante de doctorado en el grupo de Nanoscopia para la Nanomedicina<\/a> dirigido por Lorenzo Albertazzi en el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC).<\/p>\n","protected":false},"author":4,"featured_media":74694,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1055,1056,1152,1058],"post_formats":[],"class_list":["post-74697","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-icms-es","tag-lorenzo-albertazzi-es","tag-pau-gorostiza-es","tag-tue-es"],"yoast_head":"\nNuevos bloques qu\u00edmicos tipo "lego" para soluciones de salud - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/new-chemical-lego-blocks-for-health-solutions\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuevos bloques qu\u00edmicos tipo "lego" para soluciones de salud - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC desarrollan nuevas mol\u00e9culas de respuesta m\u00faltiple capaces de autoensamblarse en el agua formando estructuras fibrosas. Las llamadas mol\u00e9culas disc\u00f3ticas muestran sensibilidad a la temperatura, la luz, el pH y la fuerza i\u00f3nica y pueden mostrar un gran potencial para aplicaciones m\u00e9dicas como sistemas de administraci\u00f3n de medicamentos, diagn\u00f3stico o ingenier\u00eda de tejidos. Edgar Fuentes es un estudiante de doctorado en el grupo de Nanoscopia para la Nanomedicina dirigido por Lorenzo Albertazzi en el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/new-chemical-lego-blocks-for-health-solutions\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-02T16:13:43+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T10:54:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/06\/JACS_web.png\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"272\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/new-chemical-lego-blocks-for-health-solutions\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/new-chemical-lego-blocks-for-health-solutions\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Nuevos bloques qu\u00edmicos tipo \u00ablego\u00bb para soluciones de salud\",\"datePublished\":\"2020-06-02T16:13:43+00:00\",\"dateModified\":\"2020-06-15T10:54:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/new-chemical-lego-blocks-for-health-solutions\\\/\"},\"wordCount\":460,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/new-chemical-lego-blocks-for-health-solutions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/JACS_web.png\",\"keywords\":[\"ICMS\",\"lorenzo albertazzi\",\"Pau Gorostiza\",\"TUE\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/new-chemical-lego-blocks-for-health-solutions\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/new-chemical-lego-blocks-for-health-solutions\\\/\",\"name\":\"Nuevos bloques qu\u00edmicos tipo \\\"lego\\\" para soluciones de salud - 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