{"id":7664,"date":"2013-08-28T10:11:58","date_gmt":"2013-08-28T10:11:58","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/disenando-biomateriales-en-la-nanoescala\/"},"modified":"2015-10-20T14:15:51","modified_gmt":"2015-10-20T14:15:51","slug":"disenando-biomateriales-en-la-nanoescala","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/disenando-biomateriales-en-la-nanoescala\/","title":{"rendered":"Dise\u00f1ando biomateriales en la nanoescala"},"content":{"rendered":"

Imagen de microscopio electronic de barrio por emisi\u00f3n de campo mostrando una muy buena interacci\u00f3n celula(rojo)-fibra.<\/p>\n

\u201cHace ya tiempo que se sabe que las propiedades mec\u00e1nicas, qu\u00edmicas y nanotopogr\u00e1ficas son capaces de condicionar la funcionalidad de las c\u00e9lulas madre, as\u00ed que un biomaterial con la habilidad de poder controlar este proceso de manera pr\u00e1ctica, reproducible y escalable ser\u00eda un hecho sin precedentes dentro de la ingenier\u00eda de tejidos,\u201d dice Nad\u00e8ge Sachot, primera autora del art\u00edculo.<\/p>\n

El equipo de investigaci\u00f3n ha conseguido ensamblar un recubrimiento de vidrio bioactivo sobre fibras polim\u00e9ricas nanoestructuradas fabricadas por electrohilado (electrospinning), creando un biomaterial con unas funcionalidades espec\u00edficas. Los intentos anteriores involucraban recubrimientos cer\u00e1micos simples o dispersiones de vidrios bioactivos en pol\u00edmeros que aumentaban su resistencia total, a costa de una baja interacci\u00f3n celular y una alta facilidad para colapsar debido a su degradaci\u00f3n en fluido biol\u00f3gico.<\/p>\n

\u201cDecidimos pues, invertir el dise\u00f1o y as\u00ed evitar los t\u00edpicos problemas que se presentaban con la falta de bioactividad, la descontrolada degradaci\u00f3n y por ende la perdida de propiedades mec\u00e1nicas,\u201d explica Nad\u00e8ge. \u201cSe utiliz\u00f3 el conocimiento publicado previamente de los diferentes materiales, los cuales se coordinaron subordinando as\u00ed sus inherentes propiedades por un bien com\u00fan, obteniendo un material con funcionalidades jerarquizadas y con un resultado sin\u00e9rgico\u201d. Un ejemplo similar ser\u00eda una bicicleta, donde cada componente \u2013 los pneum\u00e1ticos de caucho, el cuadro met\u00e1lico, las luces, el lubricante de la cadena o el asiento el\u00e1stico y flexible \u2013 se ensamblan conjuntamente en un \u00fanico ente cuya principal funci\u00f3n es la movilidad r\u00e1pida y segura, con una alta relaci\u00f3n coste-eficiencia.<\/p>\n

\u201cEl n\u00facleo de las fibras est\u00e1 formado por \u00e1cido polil\u00e1ctico, un conocido pol\u00edmero biodegradable, que act\u00faa como soporte flexible. El recubrimiento bioactivo le da un aspecto similar a la tempura japonesa,\u201d dice, \u201clo que le da unas propiedades superficiales f\u00e1cilmente modificables, y permite que la superficie interaccione eficientemente con los diferentes entes biol\u00f3gicos. Adem\u00e1s, se ha previsto que puedan promover respuestas celulares espec\u00edficas controladas, es decir, que aporten a las c\u00e9lulas madre, los est\u00edmulos qu\u00edmicos, topogr\u00e1ficos y mec\u00e1nicos necesarios, para provocar que diferencien en un tipo de c\u00e9lula particular, ya sea de hueso, endotelio, nervio, etc, y as\u00ed estimular la formaci\u00f3n de tejido nuevo. El resultado son fibras totalmente biodegradables que al final ser\u00e1n reemplazadas por el tejido nuevo regenerado.\u201d<\/p>\n

El nuevo protocolo supone una muy vers\u00e1til y prometedora alternativa, pues se puede transferir a otro tipo de estructuras permitiendo la fabricaci\u00f3n de diferentes arquitecturas dependiendo de su aplicaci\u00f3n. Este aspecto abre un amplio cat\u00e1logo de aplicaciones biom\u00e9dicas que requieran biomateriales con un definido dise\u00f1o de jerarquizadas funcionalidades, como ser\u00eda la regeneraci\u00f3n de tejido \u00f3seo, vascular, o la piel o nervioso.<\/p>\n

—<\/p>\n

Reference article:<\/strong> Sachot, N., Casta\u00f1o, O., Mateos-Timoneda, M.A., Engel, E. & Planell, J.A. (2013). Hierarchically Engineered Fibrous Scaffolds for Bone Regeneration<\/a>. Interface<\/em>, 10: 20130684<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadores del IBEC han conseguido un innovador proceso para crear un biomaterial flexible, bioactivo, biodegradable, y completamente nuevo. Supone un hito importante en la producci\u00f3n de matrices artificiales para su uso en ingenier\u00eda de tejidos.<\/h3>\n

\u00a0<\/p>\n

En una breve comunicaci\u00f3n publicada hoy en la revista Journal of the Royal Society Interface<\/em>, el grupo de Biomateriales para Terapias Regenerativas describe un nuevo y prometedor m\u00e9todo para producir andamios nanofibrosos con un recubrimiento de vidrio bioactivo de manera f\u00e1cil, barata y el cual no solo mimetiza la matriz extracelular de hueso, sino que tambi\u00e9n se enfoca al control de la respuesta celular mediante interacciones f\u00edsicas y qu\u00edmicas controladas.<\/p>\n","protected":false},"author":4,"featured_media":7659,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-7664","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nDise\u00f1ando biomateriales en la nanoescala - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/disenando-biomateriales-en-la-nanoescala\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dise\u00f1ando biomateriales en la nanoescala - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC han conseguido un innovador proceso para crear un biomaterial flexible, bioactivo, biodegradable, y completamente nuevo. 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