{"id":76906,"date":"2020-08-26T10:53:25","date_gmt":"2020-08-26T08:53:25","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=76906"},"modified":"2020-08-26T12:43:56","modified_gmt":"2020-08-26T10:43:56","slug":"la-adhesion-celular-a-la-nanoescala-es-un-factor-clave-para-la-produccion-de-cartilago-in-vitro","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/la-adhesion-celular-a-la-nanoescala-es-un-factor-clave-para-la-produccion-de-cartilago-in-vitro\/","title":{"rendered":"La adhesi\u00f3n celular a la nanoescala es un factor clave para la producci\u00f3n de cart\u00edlago in vitro"},"content":{"rendered":"

\"\"<\/p>\n

La <\/span>Organizaci\u00f3n Mundial de la Salud<\/span><\/a> estima que m\u00e1s de 300 millones de personas en el mundo sufren artrosis cada a\u00f1o. Esta enfermedad comporta la rotura progresiva y la degradaci\u00f3n del cart\u00edlago en las articulaciones, que conduce a un dolor cr\u00f3nico y a una movilidad reducida. Uno de los m\u00e9todos que actualmente existen para reparar estas lesiones es la implantaci\u00f3n de condrocitos (c\u00e9lulas de cart\u00edlago) extra\u00eddas del paciente. Sin embargo, esta t\u00e9cnica est\u00e1 limitada por la etapa de expansi\u00f3n celular requerida para generar tejidos suficientemente grandes para rellenar la lesi\u00f3n, puesto que muy a menudo los condrocitos se <\/span>desdiferencian<\/span> durante el cultivo. Ahora, el grupo de investigaci\u00f3n <\/span>Nanobioengineering<\/span> del IBEC, dirigido por el profesor Josep <\/span>Samitier<\/span>, publica en la revista <\/span>International <\/span><\/i>Journal<\/span><\/i> of Molecular <\/span><\/i>Sciences<\/span><\/i> un estudio que trata de la generaci\u00f3n de cart\u00edlago <\/span>in vitro<\/span><\/i> utilizando c\u00e9lulas madre <\/span>mesenquimales<\/span> humanas (<\/span>MSCs<\/span>). <\/span>Estas c\u00e9lulas se tienen que pre-diferenciar <\/span><\/b>in vitro<\/span><\/i><\/b> para guiar con \u00e9xito la diferenciaci\u00f3n hacia condrocitos cuando se insertan en el paciente, un proceso que se puede controlar mediante el ajuste preciso de la adhesi\u00f3n celular al sustrato durante el cultivo celular.<\/span><\/b>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

En el grupo desarrollamos herramientas para modular las interacciones sustrato-c\u00e9lula a la <\/span>nanoescala<\/span> para descifrar su impacto en la generaci\u00f3n de tejidos y en el desarrollo de enfermedades\u201d. <\/span><\/p>\n

Ignasi<\/span> Casanellas<\/span>,<\/span><\/p>\n

primer autor del trabajo y estudiante de doctorado en el laboratorio del profesor Josep <\/span>Samitier<\/span>.<\/span>\u00a0<\/span><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

La estructura del <\/span><\/b>nanopatr\u00f3n<\/span><\/b> determina la correcta formaci\u00f3n del cart\u00edlago<\/span><\/b>\u00a0<\/span><\/p>\n

Las <\/span>MSCs<\/span> son c\u00e9lulas <\/span>multipotentes<\/span> que se diferencian, entre otros, en condrocitos. La formaci\u00f3n de cart\u00edlago empieza con la condensaci\u00f3n de las c\u00e9lulas <\/span>mesenquimal<\/span>e<\/span>s<\/span> que migran unas hacia las otras para formar agregados celulares tridimensionales. En este trabajo, la condensaci\u00f3n <\/span>mesenquimal<\/span> se mejor\u00f3 ajustando el nivel de adherencia entre <\/span>MSCs<\/span> y el sustrato a la <\/span>nanoescala<\/span>. Esto promueve la migraci\u00f3n direccional de c\u00e9lulas, contribuye a la estabilidad mec\u00e1nica de los agregados celulares y <\/span>mejora las interacciones c\u00e9lula- c\u00e9lula, conduciendo a una mejor formaci\u00f3n del cart\u00edlago <\/span>in vitro<\/span><\/i>. Los investigadores utilizaron <\/span>MSCs<\/span> derivadas de tejido adiposo humano, una fuente f\u00e1cilmente accesible para potenciales aplicaciones cl\u00ednicas.<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

El objetivo de este trabajo es poder reparar las lesiones de cart\u00edlago usando <\/span>MSCs<\/span> f\u00e1cilmente extra\u00eddas del paciente, que se insertar\u00e1n en la lesi\u00f3n despu\u00e9s de pasar por el proceso de <\/span>precondicionamento<\/span> in vitro<\/span><\/i>. <\/span><\/p>\n

 <\/p>\n

Anna Lagunas, <\/span><\/p>\n

investigadora s\u00e9nior del grupo <\/span>Nanobioengineering<\/span> del IBEC.<\/span>\u00a0<\/span><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

El grupo del profesor <\/span>Samitier<\/span> ha utilizado <\/span>nanopatrones<\/span>, sustratos para el cultivo celular, de RGD (una secuencia <\/span>tripeptidica<\/span> que existe en varias prote\u00ednas de la matriz extracelular y es responsable de la adhesi\u00f3n celular) para controlar y modificar la adhesi\u00f3n de las <\/span>MSCs<\/span> durante las primeras etapas de la formaci\u00f3n del cart\u00edlago. Mediante la modificaci\u00f3n de la cantidad y del espacio entre los motivos RGD en los <\/span>nanopatrones<\/span>, determinaron que hay m\u00e1s diferenciaci\u00f3n cuando se utilizan <\/span>nanopatrones<\/span> S<\/span>90<\/span> (aquellos que presentan el 90% de su superficie con una distancia entre los motivos RGD inferior a 70 <\/span>nm<\/span>). Estos <\/span>nanopatrones<\/span> biocompatibles<\/span>, previamente desarrollados en colaboraci\u00f3n con el Laboratorio de <\/span>Dendr\u00edmeros<\/span> Biomim\u00e9ticos<\/span> y <\/span>Fot\u00f3nica<\/span> del Centro Andaluz de <\/span>Nanomedicina<\/span> y Biotecnolog\u00eda (<\/span>Bionand<\/span>), permiten ajustar la adhesi\u00f3n c\u00e9lula-sustrato y se pueden generar en grandes superficies, siendo por lo tanto compatible con el cultivo de tejidos. Resultados anteriores del grupo indican que los <\/span>nanopatrones<\/span> S<\/span>90<\/span> aceleran el proceso de diferenciaci\u00f3n <\/span>in vitro<\/span><\/i>. Los nuevos hallazgos muestran que se necesitan niveles de adhesi\u00f3n altos para promover la condensaci\u00f3n y viabilidad de los agregados de <\/span>MSCs<\/span>, destacando la importancia de controlar la adhesi\u00f3n c\u00e9lula-sustrato en las estrategias de ingenier\u00eda de tejidos para la reparaci\u00f3n del cart\u00edlago.\u00a0<\/span>\u00a0<\/span><\/p>\n

El estudio se ha realizado en colaboraci\u00f3n con diferentes grupos de la red CIBER-BBN (Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Bioingenier\u00eda, Biomateriales y <\/span>Nanomedicina<\/span>): Laboratorio de Bioingenier\u00eda y Regeneraci\u00f3n Tisular, Universidad de <\/span>Malaga<\/span> (LABRET-UMA).<\/span>\u00a0<\/span><\/p>\n

Art\u00edculo de refere<\/span><\/b>ncia: <\/span><\/b>Ignasi<\/span> Casanellas<\/span>, Anna Lagunas, Yolanda Vida, Ezequiel P\u00e9rez-<\/span>Inestrosa<\/span>, Jos\u00e9 A. <\/span>Andrades<\/span>, Jos\u00e9 Becerra, Josep <\/span>Samitier<\/span>. <\/span>The<\/span> Janus<\/span> Role of <\/span>Adhesion<\/span> in <\/span>Chondrogenesis<\/span>.<\/span><\/a> Int<\/span><\/i>. J. Mol. <\/span><\/i>Sci<\/span><\/i>. 2020.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) desarrollan una metodolog\u00eda basada en estructuras de nanopatrones que mejoran la diferenciaci\u00f3n de c\u00e9lulas madre mesenquimales a cart\u00edlago in vitro. Este avance se podr\u00e1 aplicar a las t\u00e9cnicas de regeneraci\u00f3n del cart\u00edlago con el objetivo de tratar lesiones. <\/h3>\n","protected":false},"author":4,"featured_media":76841,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1137],"post_formats":[],"class_list":["post-76906","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-josep-samitier-es"],"yoast_head":"\nLa adhesi\u00f3n celular a la nanoescala es un factor clave para la producci\u00f3n de cart\u00edlago in vitro - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/la-adhesion-celular-a-la-nanoescala-es-un-factor-clave-para-la-produccion-de-cartilago-in-vitro\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La adhesi\u00f3n celular a la nanoescala es un factor clave para la producci\u00f3n de cart\u00edlago in vitro - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) desarrollan una metodolog\u00eda basada en estructuras de nanopatrones que mejoran la diferenciaci\u00f3n de c\u00e9lulas madre mesenquimales a cart\u00edlago in vitro. 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