{"id":78550,"date":"2020-10-26T15:21:22","date_gmt":"2020-10-26T14:21:22","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=78550"},"modified":"2020-11-24T10:56:49","modified_gmt":"2020-11-24T09:56:49","slug":"fuerzas-electricas-para-medir-futuros-dispositivos-electronicos-biocompatibles","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/fuerzas-electricas-para-medir-futuros-dispositivos-electronicos-biocompatibles\/","title":{"rendered":"Fuerzas el\u00e9ctricas para caracterizar futuros dispositivos electr\u00f3nicos biocompatibles"},"content":{"rendered":"

\"\"<\/p>\n

Representaci\u00f3n esquem\u00e1tica de la configuraci\u00f3n de microscop\u00eda diel\u00e9ctrica de barrido en l\u00edquido utilizada para medir las propiedades el\u00e9ctricas locales de un transistor de efecto de campo org\u00e1nico activado por electrolito (EGOFET) en funcionamiento. La punta afilada del electrodo montada en el sensor de fuerza\u00a0 puede detectar las propiedades el\u00e9ctricas locales de la interfaz semiconductor \/ electrolito cuando se utilizan frecuencias en el rango de MHz.<\/h6>\n

 <\/p>\n

Los biosensores electr\u00f3nicos basados en materiales org\u00e1nicos pronto podr\u00edan hacer un sue\u00f1o realidad de aparatos electr\u00f3nicos de bajo coste, desechables, flexibles y biocompatibles para la interacci\u00f3n con sistemas biol\u00f3gicos.<\/p>\n

Actualmente los biosensores electr\u00f3nicos basados en materiales org\u00e1nicos est\u00e1n evolucionando a un ritmo muy r\u00e1pido. Los dispositivos bioelectr\u00f3nicos org\u00e1nicos como el Transistor de Efecto de Campo Org\u00e1nico controlado por Electrolitos (EGOFET) o el Transistor Electroqu\u00edmico Org\u00e1nico (OECT) pueden hacer pronto realidad el sue\u00f1o de dispositivos electr\u00f3nicos de bajo coste, desechables, flexibles y biocompatibles para la interacci\u00f3n con sistemas biol\u00f3gicos. Aplicaciones basadas en estos transistores, como los biosensores org\u00e1nicos implantables para registrar la actividad el\u00e9ctrica de las neuronas en condiciones in-vivo, o el desarrollo de pieles electr\u00f3nicas prot\u00e9sicas basadas en biosensores org\u00e1nicos, son ya una realidad en los laboratorios de investigaci\u00f3n y ofrecen grandes promesas para aplicaciones m\u00e9dicas en un futuro cercano.<\/p>\n

Microscop\u00eda basada en fuerzas el\u00e9ctricas para la optimizaci\u00f3n de dispositivos<\/strong><\/h4>\n

Pese a los avances realizados, para poder llevar estos dispositivos de los laboratorios de investigaci\u00f3n al mercado se requiere una mayor optimizaci\u00f3n. El desarrollo de muchos de estos dispositivos actualmente se ve obstaculizado por la dificultad de visualizar los procesos el\u00e9ctricos y electroqu\u00edmicos que ocurren en la interfase entre el biosensor, la soluci\u00f3n l\u00edquida y el sistema biol\u00f3gico de inter\u00e9s a escalas muy peque\u00f1as (la nanoescala). En este estudio, se ha dado un importante paso para resolver este problema. Espec\u00edficamente, se ha demostrado que la conductividad y la capacitancia interfacial de las interfaces de biosensor org\u00e1nico \/ electrolito se pueden mapear con resoluci\u00f3n espacial a nanoescala en un biosensor org\u00e1nico en condiciones de funcionamiento completo. Para conseguirlo, ha sido clave una t\u00e9cnica de microscop\u00eda desarrollada hace algunos a\u00f1os en el grupo de Caracterizaci\u00f3n Bioel\u00e9ctrica a Nanoescala del IBEC liderado por el Prof. Gabriel Gomila, Profesor de la Universidad de Barcelona. Esta t\u00e9cnica, conocida como microscop\u00eda diel\u00e9ctrica de barrido en l\u00edquido, puede probar las propiedades el\u00e9ctricas de las interfaces s\u00f3lido \/ electrolito midiendo la fuerza el\u00e9ctrica entre una punta muy afilada montada en un microsc\u00f3pico especial y la superficie del biosensor.<\/p>\n

\"\" Para eliminar los efectos de apantallamiento y disipaci\u00f3n producidos por las soluciones l\u00edquidas con iones, se utilizan frecuencias en el rango Mega Hertz. La medici\u00f3n de fuerzas el\u00e9ctricas en lugar de corrientes el\u00e9ctricas, como hacen otras t\u00e9cnicas, proporciona una sensibilidad y una resoluci\u00f3n espacial incomparables a la microscop\u00eda de fuerza diel\u00e9ctrica de barrido en l\u00edquido. En el presente trabajo, se obtuvieron im\u00e1genes por primera vez de c\u00f3mo los electrones se acumulan en la interfaz biosensor \/ electrolito cuando se aplica un voltaje externo (puerta) a un EGOFET operativo y c\u00f3mo una capa aislante ultrafina nanoestructurada de solo unos pocos \u00e1tomos de espesor est\u00e1 presente en su superficie y determina el rendimiento del dispositivo. El EGOFET analizado en este estudio fue desarrollado en el grupo de la Dra. Marta Mas Torrents del ICMAB y tiene la capacidad de registrar la actividad bioel\u00e9ctrica de c\u00e9lulas excitables el\u00e9ctricas.<\/p>\n

Este estudio, al visualizar las propiedades el\u00e9ctricas de las interfases de biosensores que hasta ahora hab\u00edan permanecido invisibles, ofrece nuevas v\u00edas para la optimizaci\u00f3n del rendimiento de los dispositivos de biosensores org\u00e1nicos y allana el camino para su adopci\u00f3n m\u00e1s r\u00e1pida en aplicaciones en el \u00e1mbito m\u00e9dico.<\/p>\n

Figura: Im\u00e1genes de fuerza el\u00e9ctrica adquiridas a distancias decrecientes desde el canal de un Transistor de Efecto de Campo Org\u00e1nico controlado por Electrolitos (EGOFET) en funcionamiento. En las distancias m\u00e1s cercanas (abajo), las propiedades el\u00e9ctricas a nanoescala heterog\u00e9neas del canal emergen y se vuelven visibles y medibles.<\/h6>\n
\n

Art\u00edculo de referencia:<\/strong>\u00a0Adrica Kyndiah,\u00a0Mart\u00ed Checa,\u00a0Francesca Leonardi,\u00a0Ruben Millan\u2010Solsona,\u00a0Martina Di Muzio,\u00a0Shubham Tanwar,\u00a0Laura Fumagalli, Marta Mas\u2010Torrent, Gabriel Gomila.\u00a0Nanoscale Mapping of the Conductivity and Interfacial Capacitance of an Electrolyte\u2010Gated Organic Field\u2010Effect Transistor under Operation<\/a><\/em>. Advanced Functional Materials, 2020.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Una colaboraci\u00f3n conjunta entre el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC), el Instituto de Ciencia de Materiales de Barcelona(ICMAC) y la Universidad de Manchester han logrado crear un mapa de las propiedades el\u00e9ctricas de las interfaces el\u00e9ctricas de biosensores org\u00e1nicos \/ electrolitos a nanoescala midiendo las fuerzas el\u00e9ctricas locales. <\/h3>\n","protected":false},"author":4,"featured_media":78532,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1298,1113],"post_formats":[],"class_list":["post-78550","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-fuerzas-electricas","tag-gabriel-gomila-es"],"yoast_head":"\nFuerzas el\u00e9ctricas para caracterizar futuros dispositivos electr\u00f3nicos biocompatibles - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/fuerzas-electricas-para-medir-futuros-dispositivos-electronicos-biocompatibles\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fuerzas el\u00e9ctricas para caracterizar futuros dispositivos electr\u00f3nicos biocompatibles - 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