{"id":7943,"date":"2013-12-01T18:00:00","date_gmt":"2013-12-01T18:00:00","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/la-piel-forma-puentes-colgantes-para-favorecer-la-cicatrizacion-de-heridas\/"},"modified":"2015-01-07T13:05:10","modified_gmt":"2015-01-07T13:05:10","slug":"la-piel-forma-puentes-colgantes-para-favorecer-la-cicatrizacion-de-heridas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/la-piel-forma-puentes-colgantes-para-favorecer-la-cicatrizacion-de-heridas\/","title":{"rendered":"La piel forma \u2018puentes colgantes\u2019 para favorecer la cicatrizaci\u00f3n de heridas"},"content":{"rendered":"<p>Un nuevo estudio sobre la mec\u00e1nica del tejido epitelial (de la piel) se ha publicado hoy en la revista Nature Materials. El estudio demuestra c\u00f3mo las capas de queratinocitos humanos (las c\u00e9lulas m\u00e1s externas de la piel) forman estructuras similares a puentes colgantes sobre las heridas que favorecen el proceso de cicatrizaci\u00f3n.<\/p>\n<p>Cient\u00edficos del Instituto de Bioingenier\u00eda de Catalunya (IBEC) y sus colaboradores del Instituto de Mecanobiolog\u00eda de la Universidad Nacional de Singapur han utilizado tecnolog\u00eda de microfabricaci\u00f3n \u2013 generaci\u00f3n de estructuras en miniatura a escala microm\u00e9trica \u2013 para observar c\u00f3mo migran las c\u00e9lulas de la piel para reparar las heridas.<\/p>\n<p>A trav\u00e9s de esta t\u00e9cnica se ha demostrado que estas regiones, que no tienen el apoyo de una matriz extracelular y que no son propicias para la adhesi\u00f3n celular, son alcanzadas por \u201cpuentes\u201d multicelulares formados por l\u00e1minas de queratinocitos. De este modo, las c\u00e9lulas migratorias de la piel son capaces de continuar su avance como unidad y grupo homog\u00e9neo, para formar una barrera protectora encima de la herida.<\/p>\n<p>\u201cEstos puentes son un nuevo descubrimiento, ya que previamente se cre\u00eda que este proceso de reepitelializaci\u00f3n -de restauraci\u00f3n de la piel en una herida o quemadura- requer\u00eda un \u2018punto de apoyo\u2019 para que cada c\u00e9lula de una l\u00e1mina epitelial pudiera migrar\u201d, explica Xavier Trepat, investigador principal del IBEC. \u201cEn lugar de ello, parece ser que las c\u00e9lulas pueden extender un puente por encima de la herida y arrastrar las l\u00e1minas suspendidas a trav\u00e9s de \u00e9l.\u201d<\/p>\n<p>El estudio, que ha sido liderado por Lim Chwee Teck y Benoit Ladoux de Singapur, demuestra que esta l\u00e1mina de c\u00e9lulas suspendidas se propulsa gracias a fuerzas generadas por un sistema de actina y miosina, un tipo de prote\u00ednas motoras que puede causar la contracci\u00f3n celular. Los investigadores han descubierto que la l\u00e1mina tiene un comportamiento el\u00e1stico en lugar del comportamiento fluido m\u00e1s caracter\u00edstico de otros tipos celulares, lo que de alguna manera explica su habilidad para formar puentes colgantes multicelulares.<\/p>\n<p>\u201cNuestro estudio facilitar\u00e1 el camino para dise\u00f1ar mejores alternativas de reparaci\u00f3n y regeneraci\u00f3n de tejidos, que ayudar\u00e1n a solventar las limitaciones actuales en la ingenier\u00eda de tejidos y promover\u00e1n regeneraciones epiteliales,\u201d a\u00f1ade Benoit Ladoux. \u201cEntre las aplicaciones potenciales se incluye el tratamiento de quemaduras, de determinadas enfermedades de la piel y  de problemas asociados al envejecimiento como las \u00falceras, adem\u00e1s de ayudarnos a describir las propiedades mec\u00e1nicas de las l\u00e1minas celulares.\u201d<\/p>\n<p>&#8212;<\/p>\n<p><strong>Art\u00edculo de referencia: <\/strong>Sri Ram Krishna Vedula, Hiroaki Hirata, Mui Hoon Nai, Agust\u00ed Brug\u00e9s, Yusuke Toyama, Xavier Trepat, Chwee Teck Lim, Benoit Ladoux (2013). Epithelial bridges maintain tissue integrity during collective cell migration. <em>Nature Materials<\/em>, in press<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-7938 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/12\/natmatbridges340_210.jpg\" border=\"0\" width=\"340\" height=\"210\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/12\/natmatbridges340_210.jpg 340w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/12\/natmatbridges340_210-300x185.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/12\/natmatbridges340_210-242x150.jpg 242w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/12\/natmatbridges340_210-150x92.jpg 150w\" data-sizes=\"(max-width: 340px) 100vw, 340px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 340px; --smush-placeholder-aspect-ratio: 340\/210;\" \/>Resultados obtenidos por investigadores del IBEC y sus colaboradores facilitan el camino para conseguir una mejor y m\u00e1s r\u00e1pida cicatrizaci\u00f3n de heridas, adem\u00e1s de abrir nuevas v\u00edas de investigaci\u00f3n en la ingenier\u00eda de tejidos de la piel.<\/h3>\n","protected":false},"author":4,"featured_media":7938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-7943","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La piel forma \u2018puentes colgantes\u2019 para favorecer la cicatrizaci\u00f3n de heridas - Institute for 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