{"id":7986,"date":"2014-01-13T09:28:32","date_gmt":"2014-01-13T09:28:32","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/una-dosis-doble-de-exito-del-european-research-council-para-un-investigador-del-instituto-de-bioingenieria-de-cataluna\/"},"modified":"2015-01-07T13:21:09","modified_gmt":"2015-01-07T13:21:09","slug":"una-dosis-doble-de-exito-del-european-research-council-para-un-investigador-del-instituto-de-bioingenieria-de-cataluna","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/una-dosis-doble-de-exito-del-european-research-council-para-un-investigador-del-instituto-de-bioingenieria-de-cataluna\/","title":{"rendered":"Doble dosis de \u00e9xito del European Research Council para un investigador del Instituto de Bioingenier\u00eda de Catalu\u00f1a"},"content":{"rendered":"<\/h3>\n<p>El proyecto \u201cControl de tensi\u00f3n: Regulaci\u00f3n a multiescala de la tensi\u00f3n epitelial\u201d de Xavier Trepat, investigador del IBEC, recibir\u00e1 1,98 millones de Euros a lo largo de cinco a\u00f1os gracias al premio Consolidator Grant (destinado a investigadores con talento y potencial acreditado) y que se ha convocado por primera vez en el 2013. Este premio constituye el tercer brazo de financiaci\u00f3n b\u00e1sico de este organismo independiente y se suma a los otros dos, el Starting Grant y el Advanced Grant (ayudas a j\u00f3venes investigadores con carrera cient\u00edfica prometedora y a proyectos pioneros de alto riesgo, respectivamente). Las subvenciones del ERC son consideradas como el galard\u00f3n a la investigaci\u00f3n m\u00e1s prestigioso de Europa.<\/p>\n<p>El objetivo del proyecto de Xavier Trepat es proporcionar medidas y modelos a multiescala de la regulaci\u00f3n de la tensi\u00f3n mec\u00e1nica en monocapas celulares epiteliales. El objetivo final es profundizar nuestro conocimiento sobre la interacci\u00f3n de los est\u00edmulos qu\u00edmicos y f\u00edsicos durante el crecimiento y la remodelaci\u00f3n de los tejidos vivos. \u201cEntre estos est\u00edmulos, la tensi\u00f3n mec\u00e1nica emerge como un regulador central del destino y la funci\u00f3n celular\u201d, dice Xavier Trepat, quien tambi\u00e9n es profesor e investigador de la Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA). \u201cVamos a estudiar dos mecanismos concurrentes a microescala para regular la tensi\u00f3n mec\u00e1nica \u2013 fluidizaci\u00f3n vs. refuerzo y divisi\u00f3n celular vs. apoptosis \u2013 y a analizar como los procesos locales y las interacciones dan lugar a patrones globales de tensi\u00f3n.\u201d<\/p>\n<p>Para ello, los investigadores han desarrollado un montaje experimental para medir y perturbar la tensi\u00f3n de las monocapas a diferentes escalas de longitud. Utilizan t\u00e9cnicas como por ejemplo la microscop\u00eda de estr\u00e9s en monocapa, que desarrollaron y patentaron en 2011, en colaboraci\u00f3n con investigadores de Harvard. El grupo de Trepat espera que este montaje revele el repertorio completo de mecanismos que utilizan los tejidos epiteliales para regular la tensi\u00f3n y la din\u00e1mica y, de este modo, aclarar los procesos subyacentes del crecimiento tisular durante la regeneraci\u00f3n y el c\u00e1ncer.<\/p>\n<p>El grupo de Xavier Trepat recibir\u00e1 tambi\u00e9n 149 mil Euros del ERC para su proyecto \u201cGeles de Poliacrilamida de micro gradiente para an\u00e1lisis de electroforesis de alto rendimiento (MICROGRADIENTPAGE)\u201d bajo la estrategia de financiaci\u00f3n complementaria del 2013 Proof of Concept. Este proyecto propone un m\u00e9todo mejorado para la preparaci\u00f3n de geles de electroforesis en miniatura, que son ampliamente utilizados en la investigaci\u00f3n en ciencias de la vida. Esta nueva tecnolog\u00eda, si se convierte en una herramienta com\u00fan para la cuantificaci\u00f3n de prote\u00ednas de alto rendimiento, puede generar ingresos considerables en el mercado de la investigaci\u00f3n farmac\u00e9utica, cl\u00ednica o de investigaci\u00f3n b\u00e1sica as\u00ed como en la medicina personalizada.<\/p>\n<p>\u201cEste proyecto es el resultado del esfuerzo de equipo hecho por dos miembros de mi propio grupo, Raimon Sunyer y Xavier Serra, as\u00ed como de los servicios de apoyo del IBEC,\u201d dice Xavier Trepat, quien adem\u00e1s de estas dos subvenciones ya contaba con una Starting Grant del ERC, lo que hace de \u00e9l uno de los pocos y m\u00e1s j\u00f3venes investigadores en Europa en recibir tres ayudas consecutivas de este prestigioso organismo independiente de financiaci\u00f3n.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-7981 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat.jpg\" border=\"0\" width=\"400\" height=\"318\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat-300x238.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat-188x150.jpg 188w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat-150x119.jpg 150w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/318;\" \/> El grupo de \u00abDin\u00e1mica integrativa de c\u00e9lulas y tejidos\u00bb del Instituto de Bioingenier\u00eda de Catalunya (IBEC) ha empezado el a\u00f1o con muy buenas noticias del European Research Council (ERC); les han concedido dos premios, el Consolidator Grant y el Proof of Concept.   <\/p>\n","protected":false},"author":4,"featured_media":7981,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94],"tags":[],"post_formats":[],"class_list":["post-7986","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-institucionales"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Doble dosis de \u00e9xito del European Research Council para un investigador del Instituto de Bioingenier\u00eda de Catalu\u00f1a - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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