{"id":80318,"date":"2020-11-28T09:04:36","date_gmt":"2020-11-28T08:04:36","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=80318"},"modified":"2020-12-11T12:23:46","modified_gmt":"2020-12-11T11:23:46","slug":"descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\/","title":{"rendered":"Descubierto un mecanismo de entrada de f\u00e1rmacos al cerebro"},"content":{"rendered":"

\"\"<\/p>\n

El cerebro es el \u00f3rgano m\u00e1s caro de nuestro cuerpo en t\u00e9rminos de energ\u00eda metab\u00f3lica; aunque solo pesa alrededor del 5% de la masa corporal, consume hasta el 20% de los metabolitos y hasta el 60% de la ingesta de az\u00facar. Sin embargo, el cerebro es impermeable al 95% de los f\u00e1rmacos conocidos<\/span>, ya que\u00a0<\/span>no son capaces de cruzar lo que se conoce como barrera hematoencef\u00e1lica (BHE)<\/span>. Este hecho\u00a0<\/span>dificulta el desarrollo de la mayor\u00eda de terapias neurol\u00f3gicas<\/span>.<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

Ahora, un equipo formado por cient\u00edficos de China, EE.UU., Italia, Reino Unido y Espa\u00f1a, liderado por el profesor de investigaci\u00f3n ICREA\u00a0\u00a0<\/span>Giuseppe Battaglia<\/span><\/a>\u00a0del grupo\u00a0<\/span>Molecular Bionics<\/span><\/a>\u00a0del\u00a0<\/span>Instituto de Bioingenier\u00eda de Catalu\u00f1a<\/span><\/a>\u00a0(IBEC)<\/span>,<\/span>\u00a0ha descrito c\u00f3mo se da el transporte de mol\u00e9culas a trav\u00e9s de las c\u00e9lulas endoteliales del cerebro, ubicadas en la BHE. El estudio, publicado en la prestigiosa revista\u00a0<\/span>Science Adv<\/span>a<\/span>nces<\/span><\/a>, muestra, a partir del modelo basado en<\/span>\u00a0una prote\u00edna, la L<\/span>RP1 (<\/span>prote\u00edna 1 relacionada con el receptor de lipoprote\u00ednas de baja densidad<\/span>)<\/span>\u00a0c\u00f3mo la avidez de la carga con los receptores (es decir, qu\u00e9 tan fuerte est\u00e1 unida a ellos) determina<\/span>\u00a0si las\u00a0<\/span>mol\u00e9culas<\/span>\u00a0<\/span>atraviesan<\/span>\u00a0la<\/span>s c\u00e9lulas endoteliales de la\u00a0<\/span>BHE y llegan al cerebro, o\u00a0<\/span>si<\/span>,<\/span>\u00a0por lo contrario\u00a0<\/span>son degradadas en\u00a0<\/span>su\u00a0<\/span>interior<\/span>\u00a0y no logran atravesar esa barrera.\u00a0<\/span>\u00a0<\/span><\/p>\n

Una \u00ablanzadera\u00bb para viajar al cerebro\u00a0<\/strong><\/h2>\n

Con<\/span>\u00a0el fin de dilucidar el tr\u00e1fico de<\/span>\u00a0sustancias<\/span>, los investigadores utilizaron modelos\u00a0<\/span>in vitro<\/span><\/i>\u00a0e\u00a0<\/span>in vivo<\/span><\/i>\u00a0de\u00a0<\/span>BHE. En concreto,\u00a0<\/span>inyectaron en ratas y ratones mol\u00e9culas sint\u00e9ticas con\u00a0<\/span>diferentes ligandos LRP1, llamad<\/span>o<\/span>s\u00a0polimerosomas<\/span>, del\u00a0<\/span>tama\u00f1o similar al de un virus<\/span>. De esta forma pudieron evaluar<\/span>\u00a0<\/span>la capacidad de\u00a0<\/span>las mol\u00e9culas\u00a0<\/span>para unirse entre s\u00ed<\/span>, y consecuentemente el control de la uni\u00f3n mediada por LRP1<\/span>, la base para controlar las\u00a0<\/span>sustancias<\/span>\u00a0que cruzan la BHE.\u00a0<\/span>\u00a0<\/span><\/p>\n

\"\"
Fig 1.<\/figcaption><\/figure>\n

Los resultados del estudio apuntan a la fuerza con la que las sustancias se unen al receptor LRP1 como factor clave en la regulaci\u00f3n del transporte a trav\u00e9s de la membrana hematoencef\u00e1lica.\u00a0<\/span>\u00a0<\/span><\/p>\n

 <\/p>\n

 <\/p>\n


\nEsquema que muestra el trasporte transcelular mediado por syndapin-2 y la degradaci\u00f3n intracelular de LRP1.\u00a0<\/span><\/span>Fuente:\u00a0<\/span><\/span>On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias<\/span><\/span><\/a>.<\/span><\/span>\u00a0<\/span><\/span>Science<\/span>\u00a0<\/span>Advances<\/span>, 2020.<\/span><\/span>\u00a0<\/span><\/h6>\n


\nEste trabajo describe<\/span>,<\/span>\u00a0por primera vez<\/span>,<\/span>\u00a0el mecanismo por el cual el receptor LRP1 activa el transporte vesicular o tubular<\/span>\u00a0(el que permite que una mol\u00e9cula atraviese una c\u00e9lula)<\/span>\u00a0<\/span>y\u00a0<\/span>c\u00f3mo la avidez\u00a0<\/span>de uni\u00f3n\u00a0<\/span>entre la carga a transportar y el receptor juega un papel clave. As\u00ed, en los casos en los que la energ\u00eda de uni\u00f3n o la avidez es alta, las c\u00e9lulas inician la formaci\u00f3n de ves\u00edculas. En este caso, la sustancia a transportar se metaboliza en su interior, degrad\u00e1ndose dentro de estas cavidades y, posiblemente, no llega a su destino ya que es consumida por la propia c\u00e9lula endotelial. Por otro lado, ante una energ\u00eda o avidez media, la prote\u00edna syndapin-2 inicia la creaci\u00f3n de los \u201cpasajes tubulares\u201d, un\u00a0<\/span>camino\u00a0<\/span>mucho m\u00e1s eficiente para\u00a0<\/span>cruzar la<\/span>s c\u00e9lulas endoteliales y\u00a0<\/span>llegar al cerebro.<\/span>\u00a0<\/span><\/p>\n

 <\/p>\n

\u00a0<\/em><\/strong><\/p>\n

\"\"<\/span><\/strong>Este trabajo abre nuevas v\u00edas para afrontar con \u00e9xito uno de los mayores retos de la medicina moderna: encontrar una entrada segura y eficaz por la que hacer llegar f\u00e1rmacos al cerebro.<\/span><\/span><\/strong><\/p>\n

Profesor Giuseppe Battaglia<\/em><\/strong><\/p>\n

 <\/p><\/blockquote>\n

\u00a0<\/em><\/strong><\/p>\n

Art\u00edculo de referencia: <\/em><\/strong>Xiaohe<\/span>Tian<\/span>, Diana Moreira\u00a0<\/span>Leite<\/span>,\u00a0<\/span>Edoardo<\/span>Scarpa<\/span>, Sophie\u00a0<\/span>Nyberg<\/span>, Gavin\u00a0<\/span>Fullstone<\/span>, Joe\u00a0<\/span>Forth<\/span>, Diana\u00a0<\/span>Lourenco<\/span>Matias<\/span>, Azzurra\u00a0<\/span>Apriceno<\/span>, Alessandro Poma, Aroa Duro\u00a0<\/span>Castano<\/span>,\u00a0<\/span>Manish<\/span>Vuyyuru<\/span>, Lena Harker-<\/span>Kirschneck<\/span>,\u00a0<\/span>Andela<\/span>Saric<\/span>,\u00a0<\/span>Zhongping<\/span>\u00a0Zhang, Pan\u00a0<\/span>Xiang<\/span>,\u00a0<\/span>Bin<\/span>Fang<\/span>,\u00a0<\/span>Yupeng<\/span>Tian<\/span>,\u00a0<\/span>Lei<\/span>Luo<\/span>, Loris\u00a0<\/span>Rizzello<\/span>, Giuseppe\u00a0<\/span>Battaglia<\/span><\/span>. <\/span><\/span>On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias<\/span><\/span><\/a>. <\/span><\/span><\/strong>Science<\/span>Advances<\/span>, <\/span><\/span>2020.<\/span><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Un estudio internacional dirigido por el investigador del IBEC Giuseppe Battaglia describe un mecanismo y las condiciones necesarias que permiten que mol\u00e9culas atraviesen la barrera hematoencef\u00e1lica, la capa protectora del cerebro. El estudio describe el papel de la prote\u00edna LRP1 en la estabilizaci\u00f3n de pasajes tubulares, abriendo una posible v\u00eda de administraci\u00f3n m\u00e1s segura y eficiente de f\u00e1rmacos al cerebro.<\/h3>\n","protected":false},"author":4,"featured_media":80032,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1007,1106],"post_formats":[],"class_list":["post-80318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-barrera-hematoencefalica","tag-giuseppe-battaglia-es"],"yoast_head":"\nDescubierto un mecanismo de entrada de f\u00e1rmacos al cerebro - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descubierto un mecanismo de entrada de f\u00e1rmacos al cerebro - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudio internacional dirigido por el investigador del IBEC Giuseppe Battaglia describe un mecanismo y las condiciones necesarias que permiten que mol\u00e9culas atraviesen la barrera hematoencef\u00e1lica, la capa protectora del cerebro. El estudio describe el papel de la prote\u00edna LRP1 en la estabilizaci\u00f3n de pasajes tubulares, abriendo una posible v\u00eda de administraci\u00f3n m\u00e1s segura y eficiente de f\u00e1rmacos al cerebro.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-28T08:04:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-11T11:23:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/11\/male-medical-figure-with-front-brain-highlighted_1048-11823.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"626\" \/>\n\t<meta property=\"og:image:height\" content=\"417\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Descubierto un mecanismo de entrada de f\u00e1rmacos al cerebro\",\"datePublished\":\"2020-11-28T08:04:36+00:00\",\"dateModified\":\"2020-12-11T11:23:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\\\/\"},\"wordCount\":677,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/11\\\/male-medical-figure-with-front-brain-highlighted_1048-11823.jpg\",\"keywords\":[\"Barrera Hematoencef\u00e1lica\",\"Giuseppe Battaglia\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/descubierto-un-mecanismo-de-entrada-de-farmacos-al-cerebro\\\/\",\"name\":\"Descubierto un mecanismo de entrada de f\u00e1rmacos al cerebro - 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