{"id":8133,"date":"2014-03-25T12:17:21","date_gmt":"2014-03-25T12:17:21","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/ayudando-al-cerebro-a-autoregenerarse\/"},"modified":"2015-01-07T13:05:09","modified_gmt":"2015-01-07T13:05:09","slug":"ayudando-al-cerebro-a-autoregenerarse","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/ayudando-al-cerebro-a-autoregenerarse\/","title":{"rendered":"Ayudando al cerebro a autoregenerarse"},"content":{"rendered":"<p>En el estudio, liderado por la Dra. Soledad Alc\u00e1ntara del Grupo de Desarrollo Neural de la UB, los cient\u00edficos han descubierto que estos implantes biodegradables hechos de nanofibras de \u00e1cido polil\u00e1ctico (PLA) reproducen algunos aspectos del entorno natural del cerebro embrionario y estimulan la regeneraci\u00f3n del tejido.<\/p>\n<p class=\"caption\" style=\"width: 300px; float: left;\"><em><span style=\"color: #888888;\">Imagen: Andamios de nanofibras aleatorias (izquierda) y alineadas (derecha) tras una semana de la implantaci\u00f3n en el c\u00f3rtex cerebral de ratones. Las c\u00e9lulas gliales (verde) y los vasos sangu\u00edneos (rojo) penetran en el andamio alineado y no en las fibras aleatorias (rayas blancas).<\/span><\/em><\/p>\n<p>Estos implantes, conocidos en ingenier\u00eda de tejidos como \u00abandamios\u00bb, liberan L-lactato, una mol\u00e9cula que act\u00faa como se\u00f1al celular com\u00fan para inducir la angiog\u00e9nesis (formaci\u00f3n de vasos sangu\u00edneos nuevos). Tambi\u00e9n reproducen el nicho neurog\u00e9nico, es decir, el entorno en el que los progenitores neurales generan nuevas neuronas y c\u00e9lulas de gl\u00eda, que migran siguiendo los patrones de migraci\u00f3n que tienen lugar durante el desarrollo cerebral.<\/p>\n<p>\u201cLas lesiones cerebrales son la causa com\u00fan de muchas discapacidades, debido a la p\u00e9rdida de tejido nervioso y a la formaci\u00f3n de cavidades que inhiben el crecimiento de las neuronas\u201d, dice Zaida \u00c1lvarez miembro del grupo de Biomateriales para Terapias Regenerativas del IBEC y del grupo de Desarrollo Neural de la UB y primera autora del art\u00edculo. \u201cPara encontrar estrategias regenerativas efectivas que promuevan la recuperaci\u00f3n del cerebro despu\u00e9s de una lesi\u00f3n traum\u00e1tica tenemos que focalizarnos en resolver los obst\u00e1culos actuales: la d\u00e9bil integraci\u00f3n del implante y la supervivencia celular.\u201d<\/p>\n<p>Cuando los andamios de PLA dise\u00f1ados en el IBEC fueron implantados en ratones reci\u00e9n nacidos, el L-lactato liberado durante la degradaci\u00f3n actu\u00f3 como fuente de energ\u00eda alternativa motivando el crecimiento de las neuronas y activando a los progenitores end\u00f3genos. Las fibras utilizadas para construir la \u00abestructura\u00bb reprodujeron la organizaci\u00f3n natural en 3D, as\u00ed como la topolog\u00eda de la gl\u00eda radial embrionaria, lo que favoreci\u00f3 la migraci\u00f3n neuronal y la vascularizaci\u00f3n durante el crecimiento cerebral.<\/p>\n<p>\u201cMediante la mejora de los implantes ha sido posible regular los par\u00e1metros biof\u00edsicos y metab\u00f3licos que lideran la restauraci\u00f3n de la funci\u00f3n del tejido nervioso tras una lesi\u00f3n, sin la necesidad de c\u00e9lulas ex\u00f3genas, factores de crecimiento o manipulaciones gen\u00e9ticas,\u201d dice Zaida \u00c1lvarez. \u201cAunque todav\u00eda queda un largo camino por recorrer antes de que estos experimentos se puedan trasladar a la cl\u00ednica \u2013tenemos que ver si hay una respuesta regenerativa similar en ratones adultos\u2013 nuestros resultados abren perspectivas esperanzadoras y apasionantes en el dise\u00f1o de dispositivos implantables libres de c\u00e9lulas.\u201d<\/p>\n<p> <\/p>\n<p><em>&#8212;<\/em><\/p>\n<p> <strong>Art\u00edculo de Referencia: <\/strong>\u00c1lvarez, Z., Casta\u00f1o, O., Castells, A.A., Mateos-Timoneda, M.A., Planell, J.A., Engel, E. &amp; Alc\u00e1ntara, S. (2014). <a href=\"http:\/\/dx.doi.org\/10.1016\/j.biomaterials.2014.02.051\" target=\"_blank\">Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold.<\/a> <em>Biomaterials<\/em>, 35, 17, 4769\u20134781<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-8128 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain.jpg\" border=\"0\" width=\"400\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain.jpg 340w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain-300x185.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain-242x150.jpg 242w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain-150x92.jpg 150w\" data-sizes=\"(max-width: 340px) 100vw, 340px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 340px; --smush-placeholder-aspect-ratio: 340\/210;\" \/>Una nueva estrategia en medicina regenerativa puede promover la recuperaci\u00f3n de las lesiones cerebrales<\/h3>\n<p>Investigadores en regeneraci\u00f3n de tejidos del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC), de la Universidad de Barcelona (UB) y de la Universidad Polit\u00e9cnica de Catalu\u00f1a (UPC) han desarrollado un implante que estimula la regeneraci\u00f3n del tejido cerebral, especialmente en casos de lesiones pre- y postnatales.<\/p>\n","protected":false},"author":4,"featured_media":8128,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-8133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin 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