{"id":8166,"date":"2014-04-07T11:07:58","date_gmt":"2014-04-07T11:07:58","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/diagnostico-mas-rapido-y-preciso-para-las-infecciones-del-tracto-respiratorio-inferior\/"},"modified":"2015-01-07T13:05:04","modified_gmt":"2015-01-07T13:05:04","slug":"diagnostico-mas-rapido-y-preciso-para-las-infecciones-del-tracto-respiratorio-inferior","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/diagnostico-mas-rapido-y-preciso-para-las-infecciones-del-tracto-respiratorio-inferior\/","title":{"rendered":"Diagn\u00f3stico m\u00e1s r\u00e1pido y preciso para las infecciones del tracto respiratorio inferior"},"content":{"rendered":"<p><em> <\/em> <\/p>\n<p>Un estudio en el que han participado investigadores del Instituto de Bioingenier\u00eda de Catalunya (IBEC), de la Universidad de Barcelona (UB) y de la empresa catalana Biokit SA describe el desarrollo de un dispositivo \u2018en-un-chip\u2019 que es capaz de llevar a cabo una extracci\u00f3n autom\u00e1tica de muestras humanas y hacer pruebas para material gen\u00e9tico bacteriano o v\u00edrico (ADN o ARN).  <br \/> El dispositivo en miniatura est\u00e1 especialmente focalizado hacia las infecciones del tracto respiratorio inferior como la neumon\u00eda o la bronquitis.  El dispositivo hace la preparaci\u00f3n total de la muestra y extrae el ADN o el ARN purificado de pat\u00f3genos de las v\u00edas respiratorias de muestras reales de forma m\u00e1s efectiva que los m\u00e9todos existentes. Tambi\u00e9n ofrece una operaci\u00f3n de manos libres, datos autoexplicativos y resultados fiables incluso si lo utiliza una persona no experta.<\/p>\n<p> \u201cLas infecciones del tracto respiratorio inferior causan 3,4 millones de muertes al a\u00f1o a nivel mundial. Los agentes causantes de estas enfermedades pueden ser bacterias o virus, pero los m\u00e9dicos no pueden determinar cu\u00e1l es el agente bas\u00e1ndose \u00fanicamente en los s\u00edntomas cl\u00ednicos,\u201d explica Antoni Homs del grupo de Nanobioingenier\u00eda del IBEC. \u201cLos test de diagn\u00f3sticos tradicionales llevan al menos 48 horas y los laboratorios de diagn\u00f3stico habitualmente no est\u00e1n dirigidos a los pacientes con estos s\u00edntomas que se atienden en los centros de atenci\u00f3n primaria. Como resultado existe la incertidumbre sobre qu\u00e9 tipo de bacteria o virus est\u00e1 causando los s\u00edntomas. De modo que nuestro reto clave era dise\u00f1ar algo que fuera capaz de desempe\u00f1ar todo el proceso de preparaci\u00f3n de una muestra cl\u00ednica, tanto de pat\u00f3genos respiratorios bacterianos como v\u00edricos, y que aislara y recuperara el material gen\u00e9tico de una forma f\u00e1cil y r\u00e1pida\u00bb.<\/p>\n<p>La miniaturizaci\u00f3n y la integraci\u00f3n de los procedimientos completos de preparaci\u00f3n de la muestra representan un importante paso para la aplicaci\u00f3n en un dispositivo de diagn\u00f3stico inmediato de estas enfermedades. \u201cAdem\u00e1s, sabiendo que las infecciones del tracto respiratorio son la raz\u00f3n m\u00e1s com\u00fan para prescribir antibi\u00f3ticos y que la resistencia a antibi\u00f3ticos est\u00e1 altamente correlacionada con el consumo de antibi\u00f3ticos, podemos asegurar que mejorar los diagn\u00f3sticos en este campo ayudar\u00e1 a frenar la resistencia a antibi\u00f3ticos,\u201d a\u00f1ade Antoni Homs.  <\/p>\n<p>La investigaci\u00f3n, que fue llevada a cabo como parte del proyecto theraEDGE, financiado por la Uni\u00f3n Europea, y en un acuerdo de colaboraci\u00f3n entre IBEC y Biokit SA (Grupo Werfen), tambi\u00e9n ha involucrado a investigadores del Institut f\u00fcr MIkrotechnik Mainz GmbH (IMM) de Alemania y de la Universidad de Antwerp de B\u00e9lgica y el resto de un consorcio que incluye a 16 empresas e instituciones europeas.<\/p>\n<p> &#8212; <\/p>\n<p>Van Heirstraeten, L., Spang, P., Schwind, C., Drese, K. S., Ritzi-Lehnert, M., Nieto, B., Camps, M., Landgraf, B., Guasch, F., Homs Corbera, A., Samitier, J., Goossens, H., Malhotra-Kumar, S. &amp; Roeser, T. (2014). <a href=\"http:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2014\/lc\/c3lc51339d#!divAbstract\" target=\"_blank\">Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections.<\/a> <em>Lab Chip<\/em>, 14, 1519-1526<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-8161 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/04\/biokithoms.jpg\" border=\"0\" width=\"340\" height=\"210\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/04\/biokithoms.jpg 340w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/04\/biokithoms-300x185.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/04\/biokithoms-242x150.jpg 242w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/04\/biokithoms-150x92.jpg 150w\" data-sizes=\"(max-width: 340px) 100vw, 340px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 340px; --smush-placeholder-aspect-ratio: 340\/210;\" \/>Una colaboraci\u00f3n entre investigaci\u00f3n e industria desarrolla una plataforma de diagn\u00f3stico en miniatura para las infecciones respiratorias como la neumon\u00eda o la bronquitis infecciosa<\/h3>\n<h3><em> <\/em><\/h3>\n<h3>La investigaci\u00f3n est\u00e1 destacada en la portada del \u00faltimo n\u00famero de <em>Lab on a Chip<\/em><\/h3>\n","protected":false},"author":4,"featured_media":8161,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-8166","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized 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