{"id":8338,"date":"2014-07-01T15:14:23","date_gmt":"2014-07-01T15:14:23","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/why-alzheimers-patients-have-no-memory-loss-when-the-disease-starts-3\/"},"modified":"2015-08-31T08:54:49","modified_gmt":"2015-08-31T08:54:49","slug":"why-alzheimers-patients-have-no-memory-loss-when-the-disease-starts-3","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/why-alzheimers-patients-have-no-memory-loss-when-the-disease-starts-3\/","title":{"rendered":"Se descubre por qu\u00e9 los pacientes de Alzheimer no presentan p\u00e9rdida de memoria al inicio de la enfermedad"},"content":{"rendered":"

[br][br]<\/p>\n

Image: Secci\u00f3n del cortex cerebral con tau hiperfosforilada, marcada en negro. En el recuadro: Modelo de prote\u00edna PRPc<\/em><\/h6>\n

El Alzheimer es una enfermedad neurodegenerativa que se caracteriza por una p\u00e9rdida paulatina de la memoria y de otras funciones mentales, a medida que las neuronas mueren, diferentes zonas del cerebro se atrofian. Esta enfermedad es la forma de demencia m\u00e1s com\u00fan y aparece con mayor frecuencia en la poblaci\u00f3n mayor de 65 a\u00f1os (1,5 casos\/1000 personas-a\u00f1o en Europa, llegando a 69,2 casos\/1000 personas-a\u00f1o en la poblaci\u00f3n de edad superior a 90 a\u00f1os). En esta enfermedad se distinguen dos etapas: una inicial en donde los s\u00edntomas no son claros y una segunda fase donde los s\u00edntomas est\u00e1n bien definidos.<\/p>\n

El Alzheimer se atribuye principalmente a dos causas; la presencia de unos agregados extracelulares que forman placas, formados mayoritariamente por un compuesto conocido como p\u00e9ptido beta-amiloide; y una acumulaci\u00f3n de la forma hiperfosoforilada de la prote\u00edna tau, que forma peque\u00f1os ovillos en el interior de las neuronas afectadas. Hasta hoy se conoc\u00eda que la formaci\u00f3n de los ovillos de tau en las neuronas depend\u00eda de la acci\u00f3n t\u00f3xica del p\u00e9ptido beta-amiloide, pero el mecanismo de esta interacci\u00f3n entre los dos se desconoc\u00eda.<\/p>\n

Los investigadores -que trabajaron en colaboraci\u00f3n con miembros del Ciberned, del Centro de Biolog\u00eda Molecular de Madrid y del Instituto de Neuropatolog\u00eda del IDIBELL-Hospital Universitario de Bellvitge- describen la relaci\u00f3n entre el p\u00e9ptido beta-amiloide y la fosforilaci\u00f3n de tau y la presencia de otra prote\u00edna en las neuronas afectadas, la prote\u00edna celular pri\u00f3nica (PRPc). Los resultados muestran que cuando los niveles neuronales de PRPc son elevados hay menor cantidad de prote\u00edna tau fosforilada en el interior celular, aunque haya presencia del p\u00e9ptido beta-amiloide.<\/p>\n

\u201cEn estudios anteriores se hab\u00eda investigado sobre los niveles de PRPc en estadios avanzados de la enfermedad\u201d, explica el Dr. Jos\u00e9 Antonio del R\u00edo, investigador principal del grupo de Neurobiotecnolog\u00eda Molecular y Celular del IBEC y catedr\u00e1tico del Departamento de Biolog\u00eda Celular de la UB. \u201cPero nuestro nuevo estudio muestra, en cerebros de ratones y de humanos afectados de Alzheimer, un incremento de la prote\u00edna PRPc en los primeros estadios asintom\u00e1ticos de la enfermedad y c\u00f3mo estos niveles de PRPc van disminuyendo a medida que avanza la enfermedad\u201d.<\/p>\n

Cuando los niveles de PRPc son bajos la cantidad de tau -y su forma fosforilada formando ovillos en el interior celular- aumenta, lo que contribuye al deterioro cerebral observado en pacientes de Alzheimer. \u201cComo resultado, es razonable considerar que la sobreexpresi\u00f3n de PRPc observada en el inicio de la enfermedad forma parte de una respuesta protectora del sistema nervioso en un intento de reprimir el avance de la misma\u201d, dice el Dr. del R\u00edo \u201cConsecuentemente, los pacientes de Alzheimer no muestran d\u00e9ficits de memoria hasta los estadios avanzados de la enfermedad.\u201d<\/p>\n

Reference article:<\/strong> Cristina Vergara, Lara Ord\u00f3\u00f1ez-Guti\u00e9rrez, Francisco Wandosell, Isidre Ferrer, Jos\u00e9 Antonio del R\u00edo, Rosalina Gav\u00edn (2014). \u201cRole of PrPC expression in tau protein levels and phosphorylation in Alzheimer’s disease evolution\u201d<\/a>. Molecular Neurobiology<\/em>, Volume 51<\/span>, Issue 3<\/span>, pp 1206-1220<\/span>
\n[br]
\n>>IBEC in the Media:<\/strong><\/p>\n

http:\/\/noticias.lainformacion.com\/ciencia-y-tecnologia\/ciencias-naturales\/describen-la-causa-de-la-ausencia-de-sintomas-en-el-inicio-del-alzheimer_qbvhl2vDhSnPq5PLYA6mU2\/<\/a><\/p>\n

http:\/\/www.gacetamedica.com\/noticias-medicina\/2014-07-04\/especializada\/la-disminucion-progresiva-de-prpc-marca-la-evolucion-sintomatica-en-ea\/pagina.aspx?idart=848956<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

En un art\u00edculo publicado en Molecular Neurobiology<\/em>, investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y de la Universidad de Barcelona (UB), revelan que nuestro sistema nervioso env\u00eda, de manera natural, una respuesta protectora en un intento de reprimir el avance del Alzheimer. <\/h3>\n

Ello contribuir\u00eda al hecho de que los pacientes no muestran d\u00e9ficits de memoria en la primera etapa de la enfermedad.<\/p>\n","protected":false},"author":4,"featured_media":8334,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-8338","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nSe descubre por qu\u00e9 los pacientes de Alzheimer no presentan p\u00e9rdida de memoria al inicio de la enfermedad - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/why-alzheimers-patients-have-no-memory-loss-when-the-disease-starts-3\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Se descubre por qu\u00e9 los pacientes de Alzheimer no presentan p\u00e9rdida de memoria al inicio de la enfermedad - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En un art\u00edculo publicado en Molecular Neurobiology, investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y de la Universidad de Barcelona (UB), revelan que nuestro sistema nervioso env\u00eda, de manera natural, una respuesta protectora en un intento de reprimir el avance del Alzheimer. 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