{"id":8350,"date":"2014-07-07T07:06:49","date_gmt":"2014-07-07T07:06:49","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\/"},"modified":"2015-10-20T14:04:37","modified_gmt":"2015-10-20T14:04:37","slug":"la-heparina-muestra-una-doble-actividad-contra-la-malaria","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\/","title":{"rendered":"La heparina muestra una doble actividad contra la malaria"},"content":{"rendered":"<p>La heparina (izquierda), adsorbida electrost\u00e1ticamente sobre los liposomas con carga positiva y cargados con primaquina, medicamento antimal\u00e1rico, fue capaz de triplicar la actividad en cultivos de<em> P. falciparum<\/em> del f\u00e1rmaco encapsulado. En concentraciones inferiores a las que inducen anticoagulaci\u00f3n de la sangre de rat\u00f3n in vivo, la actividad parasiticida result\u00f3 ser la suma de las actividades separadas de heparina libre como antimal\u00e1rico y de heparina unida al liposoma como elemento vectorizador para la primaquina encapsulada.<\/p>\n<p>Los investigadores observaron mediante im\u00e1genes de fluorescencia confocal y de microscop\u00eda electr\u00f3nica que al cabo de 30 minutos de haber tratado gl\u00f3bulos rojos infectados por Plasmodium con heparina, \u00e9sta hab\u00eda penetrado los par\u00e1sitos intracelulares.<\/p>\n<p>Xavier Fern\u00e1ndez-Busquets, investigador IBEC e ISGlobal y coordinador del estudio, comenta que \u201cestos resultados abren la puerta a mejorar el tratamiento con heparina contra la malaria debido a su actividad aditiva como f\u00e1rmaco y como elemento vectorizador espec\u00edfico de otros antimal\u00e1ricos; sin embargo, ser\u00e1 necesario realizar m\u00e1s investigaci\u00f3n a nivel cl\u00ednico para comprobar el papel de la heparina en pacientes infectados por <em>Plasmodium<\/em>\u201d.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Referencia del art\u00edculo:<\/strong> Marques J, Moles E, Urb\u00e1n P, Prohens R, Busquets MA, Sevrin C, Grandfils C, Fern\u00e0ndez-Busquets X. (2014). \u00ab<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1549963414003141\" target=\"_blank\">Application of heparin as a dual agent with antimalarial and liposome targeting activities towards Plasmodium-infected red blood cells.<\/a>\u00bb <em>Nanomedicine<\/em>, 10, 8, p1719\u20131728<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-8345 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014.jpg\" border=\"0\" width=\"340\" height=\"210\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014.jpg 340w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014-300x185.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014-242x150.jpg 242w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014-150x92.jpg 150w\" data-sizes=\"(max-width: 340px) 100vw, 340px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 340px; --smush-placeholder-aspect-ratio: 340\/210;\" \/>Una investigaci\u00f3n publicada en Nanomedicine y llevada a cabo por cient\u00edficos del IBEC, ISGlobal y la UB abre la puerta a mejorar el tratamiento de la malaria mediante heparina.<\/h3>\n<p>El estudio publicado en Nanomedicine explora si la heparina, que ha mostrado tener actividad contra la malaria y afinidad de uni\u00f3n espec\u00edfica para los gl\u00f3bulos rojos infectados por <em>Plasmodium falciparum<\/em> frente a los gl\u00f3bulos no infectados, puede mostrar ambas propiedades y unirlas en una estrategia de administraci\u00f3n de f\u00e1rmacos contra la malaria. En este caso la heparina tendr\u00eda un doble papel como antimal\u00e1rico y como elemento de focalizaci\u00f3n de las nanopart\u00edculas cargadas con f\u00e1rmacos que actuar\u00edan al unirse a los gl\u00f3bulos rojos infectados. Este estudio, llevado a cabo por investigadores del CRESIB, centro de investigaci\u00f3n del Instituto de Bioingenier\u00eda de Catalunya (IBEC), de ISGlobal y de la Universitat de Barcelona,  ha sido publicado en Nanomedicine.<\/p>\n","protected":false},"author":4,"featured_media":8346,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-8350","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La heparina muestra una doble actividad contra la malaria - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La heparina muestra una doble actividad contra la malaria - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Una investigaci\u00f3n publicada en Nanomedicine y llevada a cabo por cient\u00edficos del IBEC, ISGlobal y la UB abre la puerta a mejorar el tratamiento de la malaria mediante heparina. El estudio publicado en Nanomedicine explora si la heparina, que ha mostrado tener actividad contra la malaria y afinidad de uni\u00f3n espec\u00edfica para los gl\u00f3bulos rojos infectados por Plasmodium falciparum frente a los gl\u00f3bulos no infectados, puede mostrar ambas propiedades y unirlas en una estrategia de administraci\u00f3n de f\u00e1rmacos contra la malaria. En este caso la heparina tendr\u00eda un doble papel como antimal\u00e1rico y como elemento de focalizaci\u00f3n de las nanopart\u00edculas cargadas con f\u00e1rmacos que actuar\u00edan al unirse a los gl\u00f3bulos rojos infectados. Este estudio, llevado a cabo por investigadores del CRESIB, centro de investigaci\u00f3n del Instituto de Bioingenier\u00eda de Catalunya (IBEC), de ISGlobal y de la Universitat de Barcelona, ha sido publicado en Nanomedicine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2014-07-07T07:06:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-10-20T14:04:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"340\" \/>\n\t<meta property=\"og:image:height\" content=\"210\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"La heparina muestra una doble actividad contra la malaria\",\"datePublished\":\"2014-07-07T07:06:49+00:00\",\"dateModified\":\"2015-10-20T14:04:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\\\/\"},\"wordCount\":244,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2014\\\/07\\\/heparin2014.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/la-heparina-muestra-una-doble-actividad-contra-la-malaria\\\/\",\"name\":\"La heparina muestra una doble actividad contra la malaria - 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