{"id":8416,"date":"2014-09-03T09:40:48","date_gmt":"2014-09-03T09:40:48","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/cientificos-desarrollan-el-primer-farmaco-regulado-por-luz-dirigido-a-las-proteinas-mas-comunes\/"},"modified":"2015-08-24T14:12:47","modified_gmt":"2015-08-24T14:12:47","slug":"cientificos-desarrollan-el-primer-farmaco-regulado-por-luz-dirigido-a-las-proteinas-mas-comunes","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/cientificos-desarrollan-el-primer-farmaco-regulado-por-luz-dirigido-a-las-proteinas-mas-comunes\/","title":{"rendered":"Cient\u00edficos desarrollan el primer f\u00e1rmaco regulado por luz dirigido a las prote\u00ednas m\u00e1s comunes"},"content":{"rendered":"
Arriba: Alloswitch-1 es el primer modulador de luz alost\u00e9rico controlado por un receptor acoblado a la prote\u00edna G. Es selectivo para el receptor de glutamato metabotr\u00f3pico (mGlu5) y permite el control \u00f3ptico de se\u00f1alizaci\u00f3n mGlu5 in vivo.<\/h6>\n

Los investigadores, del IBEC, IQAC-CSIC, UAB e IDIBELL en Barcelona y del IGF-CNRS de Montpellier, Francia, han desarrollado una peque\u00f1a mol\u00e9cula agente terap\u00e9utico que al unirse espec\u00edficamente en el lugar no-activo, o lugar alost\u00e9rico, de la prote\u00edna diana es capaz de modular sus receptores. Los moduladores alost\u00e9ricos tienen numerosas ventajas comparados con los f\u00e1rmacos tradicionales, ofrecen una mayor selectividad para unirse a los receptores espec\u00edficos, se liberan de forma sincronizada de acuerdo a la actividad de la prote\u00edna y su potencial de toxicidad es menor.<\/p>\n

\u201cPara construir un modulador fotocontrolable para un receptor acoplado a prote\u00edna G hemos tenido que desarrollar un nuevo concepto de dise\u00f1o qu\u00edmico en el que el fotoconmutable no est\u00e1 unido al f\u00e1rmaco sino que est\u00e1 insertado en el farmac\u00f3foro, que es el grupo de \u00e1tomos de una mol\u00e9cula de un f\u00e1rmaco que son responsables de su acci\u00f3n,\u201d explica Pau Gorostiza, investigador principal del grupo de Nanosondas y Nanoconmutadores del IBEC. \u201cTambi\u00e9n hemos tenido un poco de suerte porque no solo hemos obtenido un ligando fotoconmutable para estas prote\u00ednas, sino que tambi\u00e9n es uno de los moduladores alost\u00e9ricos m\u00e1s potentes y selectivos de su clase\u201d.<\/p>\n

Los efectos de este compuesto \u2018optofarmacol\u00f3gico\u2019 pueden ser controlados remotamente en el espacio y en el tiempo en organismos vivos. Esta es una ventaja en comparaci\u00f3n con las manipulaciones optogen\u00e9ticas que requieren la sobreexpresi\u00f3n de genes utilizando virus, por ejemplo.<\/p>\n

Peque\u00f1as mol\u00e9culas agentes terap\u00e9uticos como Aloswitch-1, si se consigue disponer de ellos por v\u00eda oral, podr\u00edan ofrecer una ventaja competitiva respecto a los f\u00e1rmacos tradicionales que a menudo afectan a \u00f3rganos y tejidos no diana llevando a consecuencias indeseadas que pueden comprometer sus efectos beneficiosos.<\/p>\n

—<\/p>\n

Art\u00edculo de referencia:<\/em> <\/strong>Silvia Pittolo, Xavier G\u00f3mez-Santacana, Kay Eckelt, Xavier Rovira, James Dalton, Cyril Goudet, Jean-Philippe Pin, Artur Llobet, Jes\u00fas Giraldo, Amadeu Llebaria & Pau Gorostiza (2014). An allosteric modulator to control endogenous G protein-coupled receptors with light.<\/a>. Nature Chemical Biology<\/em>, 10, 813\u2013815<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Los investigadores del grupo de Nanosondas y Nanoconmutadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y sus colaboradores han anunciado el desarrollo del primer agente terap\u00e9utico controlado por luz cuyos efectos se focalizan espec\u00edficamente en la mayor clase de prote\u00ednas que son diana de f\u00e1rmacos \u2013 los receptores acoplados a prote\u00ednas G.<\/h3>\n

En la revista Nature Chemical Biology<\/em>los cient\u00edficos ponen al descubierto a Alloswitch-1, el \u00faltimo avance en su investigaci\u00f3n en f\u00e1rmacos fotoconmutables (o regulados por luz). Controlar la actividad de un f\u00e1rmaco mediante la luz significa que los agentes terap\u00e9uticos pueden ser liberados con precisi\u00f3n a un nivel local, de este modo se reduce su efecto en otras \u00e1reas y consecuentemente se reducen tambi\u00e9n los efectos secundarios, lo que a su vez ayuda a reducir la dosis requerida.<\/p>\n","protected":false},"author":4,"featured_media":8412,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-8416","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nCient\u00edficos desarrollan el primer f\u00e1rmaco regulado por luz dirigido a las prote\u00ednas m\u00e1s comunes - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/cientificos-desarrollan-el-primer-farmaco-regulado-por-luz-dirigido-a-las-proteinas-mas-comunes\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cient\u00edficos desarrollan el primer f\u00e1rmaco regulado por luz dirigido a las prote\u00ednas m\u00e1s comunes - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Los investigadores del grupo de Nanosondas y Nanoconmutadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y sus colaboradores han anunciado el desarrollo del primer agente terap\u00e9utico controlado por luz cuyos efectos se focalizan espec\u00edficamente en la mayor clase de prote\u00ednas que son diana de f\u00e1rmacos \u2013 los receptores acoplados a prote\u00ednas G. 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