{"id":85076,"date":"2021-06-15T10:26:29","date_gmt":"2021-06-15T08:26:29","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=85076"},"modified":"2021-06-25T10:07:53","modified_gmt":"2021-06-25T08:07:53","slug":"la-bioingenieria-contra-la-covid-19-acelera-gracias-a-la-marato","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/la-bioingenieria-contra-la-covid-19-acelera-gracias-a-la-marato\/","title":{"rendered":"La\u00a0Bioingenier\u00eda contra la COVID-19\u00a0acelera\u00a0gracias a\u00a0\u201cLa\u00a0Marat\u00f3\u201d\u00a0"},"content":{"rendered":"<p><img decoding=\"async\" class=\"alignleft wp-image-85068 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-300x161.png\" alt=\"\" width=\"809\" height=\"434\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-300x161.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-1024x550.png 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-768x412.png 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-1536x825.png 1536w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-150x81.png 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture.png 1991w\" data-sizes=\"(max-width: 809px) 100vw, 809px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 809px; --smush-placeholder-aspect-ratio: 809\/434;\" \/><\/p>\n<p><span data-contrast=\"none\">La bioingenier\u00eda de vanguardia que se realiza en IBEC estar\u00e1 presente en tres de los proyectos que buscar\u00e1n soluciones contra la COVID-19 gracias a financiaci\u00f3n de \u201cLa Marat\u00f3 de TV3- por la COVID-19\u201d. Estos proyectos con liderazgo, o participaci\u00f3n de IBEC, han sido seleccionados para formar parte de los 36 proyectos financiables, entres 229 candidaturas presentadas, a trav\u00e9s la \u00faltima edici\u00f3n de la popular campa\u00f1a de recaudaci\u00f3n de fondos, que consigui\u00f3 reunir, en total, cerca de 14 millones de euros. <\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><strong>N\u00faria Montserrat, profesora de investigaci\u00f3n ICREA y l\u00edder del\u00a0grupo\u00a0<a href=\"https:\/\/ibecbarcelona.eu\/ipscs\">\u201cPluripotencia para la Regeneraci\u00f3n de \u00d3rganos<\/a>\u201d\u00a0en el\u00a0Instituto de Bioingenier\u00eda de Catalu\u00f1a\u00a0(IBEC),\u00a0recibir\u00e1\u00a0398.000 \u20ac\u00a0de la edici\u00f3n 2020 de \u201cLa\u00a0Marat\u00f3\u00bb<\/strong><span data-contrast=\"auto\"><strong> para liderar el proyecto \u201cSYSTORG\u201d, con el que explorar\u00e1 las condiciones que desencadenan en casos graves de COVID-19<\/strong>.\u00a0<\/span><span data-contrast=\"auto\">Para ello, Montserrat y su equipo fusionar\u00e1n t\u00e9cnicas de la bioingenier\u00eda y la edici\u00f3n gen\u00e9tica para crear\u00a0organoides\u00a0de ri\u00f1\u00f3n (cultivos celulares que a escala milim\u00e9trica recogen ciertas caracter\u00edsticas del \u00f3rgano nativo). Mediante estos abordajes el proyecto SYSTORG adem\u00e1s utilizar\u00e1 plataformas de \u00f3rgano en un chip\u00a0(del ingl\u00e9s\u00a0<\/span><i><span data-contrast=\"auto\">organ-on-a-chip<\/span><\/i><span data-contrast=\"auto\">) a fin de emular condiciones fisiol\u00f3gicas que pueden empeorar el curso de la COVID-19. De esta manera SYSTORG podr\u00e1 explorar de manera fidedigna los cambios que se producen a nivel molecular y funcional en organoides renales, vasculares y g\u00e1stricos utilizando tecnolog\u00edas como la secuenciaci\u00f3n de RNA a nivel de c\u00e9lula \u00fanica (del ingl\u00e9s\u00a0<\/span><i><span data-contrast=\"auto\">single\u00a0cell\u00a0RNA\u00a0seq<\/span><\/i><span data-contrast=\"auto\">).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Junto a Montserrat en IBEC, participan en este proyecto dos socios internacionales; el equipo dirigido por Josef Penninger del Institut fuer Molekulare Biotechnologie GmbH (IMBA), y Ali Mirazimi, del Karolinska Institutet. Todos ellos han colaborado anteriormente en otros proyectos de investigaci\u00f3n en COVID-19, siendo pioneros en la derivaci\u00f3n y el uso de organoides renales y vasculares para entender respuestas tempranas a la infecci\u00f3n por SARS-CoV-2.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<blockquote><p>\u00a0<strong>\u201cGracias a la Marat\u00f3 de TV3 vamos a poder desarrollar tecnolog\u00edas que son necesarias para ahondar en cuestiones complejas en la enfermedad de la COVID-19. En ese sentido queremos investigar los mecanismos moleculares que explicar\u00edan porque condiciones sist\u00e9micas como la diabetes o la hiperlipidemia se asocian con un peor pron\u00f3stico de la COVID-19 desarrollando para ello organoides renales, vasculares o g\u00e1stricos\u201d.<\/strong><\/p>\n<p style=\"text-align: right;\"><strong>Nuria\u00a0Montserrat, Profesora de Investigaci\u00f3n ICREA\u00a0e\u00a0Investigadora Principal\u00a0en IBEC<\/strong><\/p>\n<\/blockquote>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Por otro lado,\u00a0el Dr.\u00a0<\/span><a href=\"https:\/\/ibecbarcelona.eu\/member\/33\/Santiago+Marco+Col%C3%A1s\/\"><span data-contrast=\"none\">Santiago Marco<\/span><\/a><span data-contrast=\"auto\">,\u00a0l\u00edder del grupo\u00a0<\/span><a href=\"https:\/\/ibecbarcelona.eu\/sensingsys\"><span data-contrast=\"auto\">\u201cProcesamiento de se\u00f1ales e informaci\u00f3n para sistemas de sensores<\/span><\/a><span data-contrast=\"auto\">\u201d en el IBEC y Profesor de la Universidad de Barcelona (UB), tambi\u00e9n recibir\u00e1 financiaci\u00f3n de La Marat\u00f3 para desarrollar el proyecto \u201cCoRespirOmics\u201d. El grupo de Santiago Marco, junto con la Fundaci\u00f3 Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (que lidera el proyecto), buscan mejorar los procesos de atenci\u00f3n al paciente y determinar qu\u00e9 intervenciones pueden mejorar el estado de los pacientes infectados por coronavirus. Para ello, contaran con una financiaci\u00f3n de 95.800 euros durante dos a\u00f1os para poder hacer una predicci\u00f3n del pron\u00f3stico respiratorio en pacientes graves de COVID-19. <\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">La evoluci\u00f3n cl\u00ednica respiratoria de COVID-19 es poco conocida, por lo que identificar las v\u00edas metab\u00f3licas que se ven alteradas y su asociaci\u00f3n con el fracaso de las estrategias de soporte ventilatorio no invasivo (NIS) es crucial para comprender la fisiopatolog\u00eda de la COVID-19, para orientar las decisiones cl\u00ednicas y determinar tratamientos terap\u00e9uticos.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<blockquote><p><strong>\u201cEn este proyecto\u00a0utilizaremos t\u00e9cnicas estad\u00edsticas y de inteligencia artificial para descubrir patrones\u00a0de metabolitos\u00a0caracter\u00edsticos que permitan entender mejor la\u00a0patofisiolog\u00eda\u00a0de la\u00a0enfermedad, e\u00a0individualizar\u00a0y adecuar\u00a0el soporte ventilatorio\u00a0en\u00a0funci\u00f3n de\u00a0la evoluci\u00f3n\u00a0temporal\u00a0de\u00a0estos\u00a0biomarcadores\u201d.<\/strong><\/p>\n<p style=\"text-align: right;\"><strong>Profesor\u00a0Santi Marco,\u00a0Investigador principal\u00a0en IBEC<\/strong><\/p>\n<\/blockquote>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Diferentes patrones metab\u00f3licos de v\u00edas espec\u00edficas pueden predecir la falla del soporte ventilatorio no invasivo (NIS) en pacientes con neumon\u00eda COVID-19. Estos patrones podr\u00edan estar asociados con alteraciones de la mec\u00e1nica respiratoria en el s\u00edndrome de dificultad respiratoria aguda (SDRA). El objetivo de este proyecto es poder crear un algoritmo de decisi\u00f3n diagn\u00f3stica y terap\u00e9utica en base a los diferentes patrones metab\u00f3licos de pacientes cr\u00edticos de COVID-19 que necesiten NIS debido a SDRA. <\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Finalmente, la investigadora s\u00e9nior\u00a0<\/span><b><span data-contrast=\"auto\">Beatriz F. Giraldo<\/span><\/b><span data-contrast=\"auto\">, del Grupo de Procesamiento e Interpretaci\u00f3n de Se\u00f1ales Biom\u00e9dicas en el IBEC y Profesora de la Universidad Polit\u00e9cnica de Catalunya (UPC) participar\u00e1 en un proyecto coordinado, liderado por la Doctora\u00a0<\/span><b><span data-contrast=\"auto\">Arantxa Mas<\/span><\/b><span data-contrast=\"auto\"> del IDIBELL y el Consorcio Sanitario Integrado, en el que se propone determinar biomarcadores del patr\u00f3n respiratorio como predictores din\u00e1micos de la mala evoluci\u00f3n en pacientes con COVID-19. Con ello se pretende hacer un seguimiento m\u00e1s preciso que permita predecir tempranamente la evoluci\u00f3n del comportamiento del sistema respiratorio, y avanzar en el tratamiento de pacientes con problemas como la neumon\u00eda derivada de COVID-19, entre otros.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<blockquote><p><strong>\u201cQueremos\u00a0recoger la mejor informaci\u00f3n posible sobre la respuesta del cuerpo al virus, a partir de se\u00f1ales fisiol\u00f3gicas relacionadas con los pulmones, el coraz\u00f3n y la temperatura, para poder tener biomarcadores que nos ayuden a predecir la evoluci\u00f3n de la enfermedad y definir posibles tratamientos.\u00bb<\/strong><\/p>\n<p style=\"text-align: right;\"><strong>Beatriz F. Giraldo, investigadora s\u00e9nior en IBEC<\/strong><\/p>\n<\/blockquote>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<h3>Tres proyectos\u00a0con el\u00a0Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) recibir\u00e1n financiaci\u00f3n de \u201cla\u00a0Marat\u00f3\u00a0de TV3\u201d para investigar\u00a0diferentes aspectos de la Covid-19.\u00a0Gracias a las aportaciones recibidas, los expertos profundizar\u00e1n en\u00a0la\u00a0comprensi\u00f3n de la\u00a0enfermedad y sus\u00a0posibles soluciones\u00a0terap\u00e9uticas,\u00a0estudiar\u00e1n mejoras en los procesos de atenci\u00f3n al paciente,\u00a0y desarrollar\u00e1n\u00a0un sistema\u00a0para\u00a0predecir la evoluci\u00f3n del\u00a0sistema respiratorio, y avanzar en el tratamiento de pacientes con\u00a0neumon\u00eda derivada de COVID19. <\/h3>\n","protected":false},"author":4,"featured_media":85068,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94],"tags":[1223,1124,1117,1119],"post_formats":[],"class_list":["post-85076","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-institucionales","tag-covid-es","tag-nuria-montserrat-es-2","tag-raimon-jane-es","tag-santiago-marco-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La\u00a0Bioingenier\u00eda contra la COVID-19\u00a0acelera\u00a0gracias a\u00a0\u201cLa\u00a0Marat\u00f3\u201d\u00a0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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