{"id":85658,"date":"2021-06-28T13:50:17","date_gmt":"2021-06-28T11:50:17","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=85658"},"modified":"2021-06-29T14:03:57","modified_gmt":"2021-06-29T12:03:57","slug":"semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\/","title":{"rendered":"Semillas cient\u00edficas para salud: investigadores en IBEC ganan dos proyectos \u201cIgnite Seed Grant\u201d del BIST"},"content":{"rendered":"<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-85659 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/Benedetta_Juanma_BIST.png\" alt=\"\" width=\"1046\" height=\"510\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/Benedetta_Juanma_BIST.png 1046w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/Benedetta_Juanma_BIST-300x146.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/Benedetta_Juanma_BIST-1024x499.png 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/Benedetta_Juanma_BIST-768x374.png 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/Benedetta_Juanma_BIST-150x73.png 150w\" data-sizes=\"(max-width: 1046px) 100vw, 1046px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1046px; --smush-placeholder-aspect-ratio: 1046\/510;\" \/><\/p>\n<p><span data-contrast=\"none\">El\u00a0<\/span><a href=\"https:\/\/bist.eu\/\" target=\"_blank\" rel=\"noopener\"><b><span data-contrast=\"none\">Barcelona\u00a0Institute\u00a0of\u00a0Science\u00a0and\u00a0Technology<\/span><\/b><\/a><span data-contrast=\"none\">\u00a0(BIST)\u00a0ha hecho p\u00fablicos hoy los cinco proyectos ganadores\u00a0de la primera fase de la quinta convocatoria\u00a0del\u00a0<\/span><b><span data-contrast=\"none\">BIST\u00a0Ignite\u00a0Programme<\/span><\/b><span data-contrast=\"none\">,\u00a0que promueve colaboraciones multidisciplinarias en las fronteras del conocimiento\u00a0para\u00a0resolver\u00a0<\/span><b><span data-contrast=\"none\">retos cient\u00edficos\u00a0y sociales\u00a0para los que la investigaci\u00f3n m\u00e1s avanzada no ha encontrado a<\/span><\/b><b><span data-contrast=\"none\">\u00fa<\/span><\/b><b><span data-contrast=\"none\">n respuesta<\/span><\/b><span data-contrast=\"none\">.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Un a\u00f1o m\u00e1s, la salud y, en concreto, la b\u00fasqueda de nuevas\u00a0alternativas terap\u00e9uticas para enfermedades hoy\u00a0incurables\u00a0centra\u00a0la mayor\u00eda de\u00a0los proyectos\u00a0premiados. Estas incluyen enfermedades neurodegenerativas como el corea de Huntington,\u00a0el c\u00e1ncer de pecho triple negativo, distrofias\u00a0musculares\u00a0como la enfermedad de Duchenne, o\u00a0el uso de oro para combatir la acumulaci\u00f3n patol\u00f3gica de c\u00e9lulas senescentes.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<h4><strong>PolySTOP: entender y controlar\u00a0la alteraci\u00f3n\u00a0gen\u00e9tica de\u00a0las\u00a0poliglutaminas\u00a0que causan\u00a0el\u00a0corea de Huntington\u00a0<\/strong><\/h4>\n<p><span data-contrast=\"none\">La expansi\u00f3n\u00a0de ciertas cadenas de amino\u00e1cidos (poliglutaminas,\u00a0<\/span><i><span data-contrast=\"none\">PolyQ<\/span><\/i><span data-contrast=\"none\">) en varias prote\u00ednas presentes en las\u00a0c\u00e9lulas neuronales\u00a0est\u00e1 detr\u00e1s\u00a0de\u00a0diversas\u00a0enfermedades neurodegenerativas, como\u00a0el corea\u00a0de Huntington, que hoy por hoy no disponen de ning\u00fan tratamiento\u00a0para curarlas\u00a0o retardar su desarrollo.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/ibecbarcelona.eu\/member\/1563\/Benedetta+Bolognesi\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Benedetta Bolognesi,<\/span><\/a><span data-contrast=\"none\">\u00a0<\/span><i><span data-contrast=\"none\">Junior\u00a0Leader<\/span><\/i><span data-contrast=\"none\"> del grupo <\/span><a href=\"https:\/\/ibecbarcelona.eu\/protein-phase-transitions-in-health-and-disease\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\"><em>Protein Phase Transitions in Health and Diseaseransiciones<\/em><\/span><\/a><span data-contrast=\"none\">\u00a0en el\u00a0Instituto de Bioingenier\u00eda de Catalunya (IBEC), y\u00a0<\/span><a href=\"https:\/\/www.irbbarcelona.org\/es\/research\/xavier-salvatella\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Xavier\u00a0Salvatella<\/span><\/a><span data-contrast=\"none\">,\u00a0l\u00edder del Laboratorio de\u00a0Biof\u00edsica Molecular en el Instituto de Investigaci\u00f3n Biom\u00e9dica de Barcelona (IRB Barcelona), liderar\u00e1n\u00a0este proyecto\u00a0que combina\u00a0la metodolog\u00eda desarrollada por el laboratorio de Bolognesi\u00a0para medir\u00a0\u201cin vivo\u201d\u00a0la agregaci\u00f3n de\u00a0esas expansiones de amino\u00e1cidos\u00a0\u2014que aplicar\u00e1n a\u00a0las m\u00e1s de 300\u00a0mutaciones de la prote\u00edna\u00a0Htt-Nt, responsable del Huntington\u2014,\u00a0con\u00a0la experiencia del equipo de\u00a0Salvatella\u00a0en el\u00a0estudio estructural de estas expansiones y el\u00a0dise\u00f1o de p\u00e9ptidos.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:2,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:540,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n<p>\u00abNuestra metodolog\u00eda nos permite analizar la propensi\u00f3n de miles de secuencias de PolyQ a producir placas amiloideas. Es una forma sistem\u00e1tica de medir como impactan esas cadenas y sus \u2018regiones adyacentes\u2019 en la agregaci\u00f3n. Con ello podemos obtener \u2018paisajes mutacionales\u2019 que nos permitir\u00e1n entender qu\u00e9 hacen exactamente esas zonas en el proceso de agregaci\u00f3n y el equipo de Xavier podr\u00e1 estudiar su estructura y dise\u00f1ar p\u00e9ptidos que puedan unirse a las glutaminas y controlar su agregacion\u201d,<strong> explica la doctora Bolognesi.\u00a0\u201cEsto\u00a0puede ofrecer\u00a0alternativas terap\u00e9uticas no solo al Huntington, sino a\u00a0otras\u00a0enfermedades neurodegenerativas que hoy no tienen tratamiento\u201d.\u00a0<\/strong><\/p>\n<h4><strong>ASITOC:\u00a0m\u00fasculos-en-un-chip y\u00a0sensores de\u00a0biomagnetismo\u00a0para acelerar\u00a0el dise\u00f1o de nuevos tratamientos de distrofia muscular\u00a0<\/strong><\/h4>\n<p><span data-contrast=\"none\">Hay m\u00e1s de 30 enfermedades hereditarias que producen distrofia muscular, algunas muy severas y de r\u00e1pido desarrollo, como la enfermedad de Duchenne, que afecta sobre todo a ni\u00f1os.\u00a0<\/span><i><span data-contrast=\"none\">\u201c<strong>Los m\u00fasculos\u00a0con\u00a0distrofia\u00a0se\u00a0mueven,\u00a0pero de modo distinto a los m\u00fasculos sanos,\u00a0por ejemplo,\u00a0presentan debilidad y tiempos de relajaci\u00f3n mayores que los m\u00fasculos sanos. Lo que nosotros intentamos hacer es reproducir\u00a0los movimientos caracter\u00edsticos de los m\u00fasculos enfermos en un dispositivo\u00a0microflu\u00eddico\u00a0(<\/strong><\/span><\/i><strong>organ-on-a-chip<i>)\u00a0e integrar la tecnolog\u00eda de sensores magn\u00e9ticos para medir las din\u00e1micas de contracci\u00f3n\u201d<\/i>, explica\u00a0<\/strong><a href=\"https:\/\/ibecbarcelona.eu\/member\/1531\/Juanma%20Fernandez%20Costa\/\" target=\"_blank\" rel=\"noopener\"><strong>Juan\u00a0Manuel Fern\u00e1ndez-Costa<\/strong><\/a><span data-contrast=\"none\">, investigador postdoctoral\u00a0en el\u00a0grupo\u00a0<\/span><a href=\"https:\/\/ibecbarcelona.eu\/biosensors\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Biosensores para Bioingenier\u00eda<\/span><\/a><span data-contrast=\"none\">\u00a0del\u00a0IBEC,\u00a0y\u00a0co-lider\u00a0del proyecto junto con\u00a0<\/span><a href=\"https:\/\/www.icfo.eu\/lang\/research\/groups\/member-details?gid=20&amp;people_id=1689\" target=\"_blank\" rel=\"noopener\">Michael\u00a0Tayler<\/a><span data-contrast=\"none\">, investigador postdoctoral\u00a0y becario la Caixa Junior Leader\u00a0del Instituto de Ciencias Fot\u00f3nicas (ICFO).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Ambas tecnolog\u00edas\u00a0son muy novedosas, pero aqu\u00ed presentan el reto a\u00f1adido de\u00a0reproducir el movimiento del m\u00fasculo afectado por una patolog\u00eda\u00a0y de medir las alteraciones\u00a0biomagn\u00e9ticas\u00a0de este movimiento, que son extremadamente\u00a0d\u00e9biles.\u00a0<\/span><i><span data-contrast=\"none\">\u201cLa medici\u00f3n de campos magn\u00e9ticos de fuentes biol\u00f3gicas ya se aplica al cerebro\u00a0(magneto-encefalograf\u00eda) y al coraz\u00f3n. Pero\u00a0los campos magn\u00e9ticos\u00a0que producen estos \u00f3rganos son de un orden de magnitud tres veces mayor que las que genera\u00a0un m\u00fasculo-en-un-chip\u201d<\/span><\/i><span data-contrast=\"none\">, subraya Michael\u00a0Tayler.\u00a0<\/span><i><span data-contrast=\"none\">\u201cEl\u00a0proyecto\u00a0es absolutamente pionero en este \u00e1mbito\u201d.<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">El objetivo final es tener un dispositivo capaz de medir los cambios que se producen en el m\u00fasculo cuando se le aplican ciertos compuestos, lo que permitir\u00eda usarlo para testear nuevos f\u00e1rmacos y tratamientos.\u00a0El sistema podr\u00eda tener aplicaciones no solo para los casos m\u00e1s severos de\u00a0distrofia, sino para las\u00a0m\u00e1s de\u00a0700 enfermedades\u00a0musculares que se conocen e incluso en otras patolog\u00edas donde se produzca un cambio de potencial\u00a0biomagn\u00e9tico\u00a0que pueda ser medido\u00a0por esta tecnolog\u00eda.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Cada uno de los cinco proyectos recibir\u00e1 una aportaci\u00f3n de 20.000 euros para llevar a cabo la primera fase, de diez meses, tras los cuales y en funci\u00f3n de los resultados obtenidos, un panel de expertos seleccionar\u00e1 dos de los proyectos que recibir\u00e1n una financiaci\u00f3n adicional de 50.000 euros.\u00a0El objetivo del programa es ayudar al arranque de proyectos\u00a0de\u00a0<\/span><b><span data-contrast=\"none\">enfoque muy innovador y alto potencial<\/span><\/b><span data-contrast=\"none\">, que puedan aplicar posteriormente con \u00e9xito a convocatorias competitivas de financiaci\u00f3n. Desde el lanzamiento de la primera convocatoria, en diciembre de 2016, se han llevado a cabo\u00a0<\/span><b><span data-contrast=\"none\">5 ediciones del programa BIST\u00a0Ignite<\/span><\/b><span data-contrast=\"none\">, en las que han recibido financiaci\u00f3n un total de\u00a0<\/span><b><span data-contrast=\"none\">23 proyectos<\/span><\/b><span data-contrast=\"none\">,\u00a0por\u00a0un monto total de 810.000 euros, y ha contado con la participaci\u00f3n de m\u00e1s de 170 investigadores de los siete centros BIST.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">M\u00e1s informaci\u00f3n sobre todos los proyectos concedidos:\u00a0<\/span><a href=\"https:\/\/bist.eu\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">BIST<\/span><\/a><span data-contrast=\"none\">.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:240,&quot;335559739&quot;:200,&quot;335559740&quot;:360}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<h3>Investigadores del IBEC reciben dos \u201cIgnite Seed Grants\u201d con los que combinar\u00e1n sus capacidades con otros miembros del BIST para buscar respuestas cient\u00edficas a retos en salud. Benedetta Bolognesi estudiar\u00e1, con el IRB, la enfermedad de Huntington y otras patolog\u00edas neurodegenerativas sin tratamiento. Por otro lado, Juan Manuel Fern\u00e1ndez-Costa e investigadores en ICFO desarrollar\u00e1n m\u00fasculos-en-un-chip y sensores de biomagnetismo para acelerar el dise\u00f1o de nuevos tratamientos de la distrofia muscular.<\/h3>\n","protected":false},"author":4,"featured_media":85662,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94],"tags":[1108,488,1512,1513],"post_formats":[],"class_list":["post-85658","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-institucionales","tag-benedetta-bolognesi-es","tag-bist-es","tag-ignite-seed-grant","tag-juan-manuel-fernandez-costa"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Semillas cient\u00edficas para salud: investigadores en IBEC ganan dos proyectos \u201cIgnite Seed Grant\u201d del BIST - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Semillas cient\u00edficas para salud: investigadores en IBEC ganan dos proyectos \u201cIgnite Seed Grant\u201d del BIST - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC reciben dos \u201cIgnite Seed Grants\u201d con los que combinar\u00e1n sus capacidades con otros miembros del BIST para buscar respuestas cient\u00edficas a retos en salud. Benedetta Bolognesi estudiar\u00e1, con el IRB, la enfermedad de Huntington y otras patolog\u00edas neurodegenerativas sin tratamiento. Por otro lado, Juan Manuel Fern\u00e1ndez-Costa e investigadores en ICFO desarrollar\u00e1n m\u00fasculos-en-un-chip y sensores de biomagnetismo para acelerar el dise\u00f1o de nuevos tratamientos de la distrofia muscular.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-28T11:50:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-06-29T12:03:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/Benedetta_Juanma_BIST_500.png\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"243\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Semillas cient\u00edficas para salud: investigadores en IBEC ganan dos proyectos \u201cIgnite Seed Grant\u201d del BIST\",\"datePublished\":\"2021-06-28T11:50:17+00:00\",\"dateModified\":\"2021-06-29T12:03:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\\\/\"},\"wordCount\":917,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2021\\\/06\\\/Benedetta_Juanma_BIST_500.png\",\"keywords\":[\"Benedetta Bolognesi\",\"BIST\",\"Ignite Seed Grant\",\"Juan Manuel Fern\u00e1ndez-Costa\"],\"articleSection\":[\"Noticias institucionales\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/semillas-cientificas-para-salud-investigadores-en-ibec-ganan-dos-proyectos-ignite-seed-grant-del-bist\\\/\",\"name\":\"Semillas cient\u00edficas para salud: investigadores en IBEC ganan dos proyectos \u201cIgnite Seed Grant\u201d del BIST - 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