{"id":85926,"date":"2021-06-15T14:29:31","date_gmt":"2021-06-15T12:29:31","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=85926"},"modified":"2021-07-05T18:01:35","modified_gmt":"2021-07-05T16:01:35","slug":"los-mini-organos-de-bioingenieria-avanzan-en-la-lucha-contra-el-cancer-gracias-a-la-aecc","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/los-mini-organos-de-bioingenieria-avanzan-en-la-lucha-contra-el-cancer-gracias-a-la-aecc\/","title":{"rendered":"Los mini-\u00f3rganos de\u00a0bioingenier\u00eda\u00a0avanzan\u00a0en\u00a0la lucha contra el c\u00e1ncer gracias a la AECC\u00a0"},"content":{"rendered":"<p><span data-contrast=\"auto\"><img decoding=\"async\" class=\"alignleft wp-image-85927 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/Organoids-per-AECC.png\" alt=\"\" width=\"821\" height=\"386\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/Organoids-per-AECC.png 602w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/Organoids-per-AECC-300x141.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/Organoids-per-AECC-150x71.png 150w\" data-sizes=\"(max-width: 821px) 100vw, 821px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 821px; --smush-placeholder-aspect-ratio: 821\/386;\" \/>El carcinoma de c\u00e9lulas renales es un tipo agresivo de c\u00e1ncer,\u00a0donde\u00a0el subtipo de c\u00e9lula clara (CcRCC) es el m\u00e1s frecuente. Seg\u00fan los datos acumulados durante la \u00faltima d\u00e9cada, m\u00e1s del 50% de los tumores malignos renales se detectan accidentalmente debido al uso generalizado de la imagen abdominal. Por lo tanto, un m\u00e9todo de detecci\u00f3n precoz es crucial para poder tratar este tipo de enfermedad y facilitar\u00edan el desarrollo de estrategias de intervenci\u00f3n temprana.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:257,&quot;469777462&quot;:[3015],&quot;469777927&quot;:[0],&quot;469777928&quot;:[1]}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Hasta el momento, no exist\u00edan modelos humanos\u00a0basados en la generaci\u00f3n de\u00a0organoides\u00a0renales para este tipo\u00a0de c\u00e1ncer renal.\u00a0Es por ello que la investigadora\u00a0Nuria Montserrat\u00a0y su grupo\u00a0de investigaci\u00f3n\u00a0en el IBEC, junto con sus colaboradores en Vall\u00a0d\u2019Hebron\u00a0Institut\u00a0d\u2019Oncologia, ICO-IDIBELL y Hospital\u00a0Cl\u00ednic\u00a0de Barcelona, recibieron, en 2017,\u00a0300.000 euros de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer para la\u00a0<\/span><span data-contrast=\"auto\">investigaci\u00f3n en c\u00e1ncer renal utilizando\u00a0organoides.\u00a0<\/span><span data-contrast=\"auto\">Los\u00a0organoides\u00a0de ri\u00f1\u00f3n\u00a0son agregados de c\u00e9lulas cultivadas que constituyen tejidos de un tama\u00f1o reducido (de micr\u00f3metros a cent\u00edmetros), dotados de las caracter\u00edsticas estructurales y funcionales\u00a0al ri\u00f1\u00f3n humano. Este m\u00e9todo permite estudiar de manera m\u00e1s fiel y precisa la enfermedad, respecto\u00a0a los cultivos celulares tradicionales. Adem\u00e1s, este abordaje permite identificar nuevos marcadores de la iniciaci\u00f3n de la enfermedad.\u00a0<\/span><b><span data-contrast=\"auto\">Durante este tiempo, los investigadores han desarrollado\u00a0organoides\u00a0de ri\u00f1\u00f3n a partir de c\u00e9lulas madre pluripotentes humanas que les ha permitido\u00a0lograr dos objetivos:\u00a0observar c\u00f3mo se desarrolla el tejido en este \u00f3rgano, y, por otro lado, gracias a t\u00e9cnicas de edici\u00f3n gen\u00e9tica, manipular estos\u00a0minirri\u00f1ones\u00a0para que\u00a0presenten\u00a0mutaciones para este tipo de c\u00e1ncer\u00a0pudiendo\u00a0identificar, as\u00ed,\u00a0signos tempranos del desarrollo\u00a0para esta\u00a0enfermedad.\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:257,&quot;469777462&quot;:[3015],&quot;469777927&quot;:[0],&quot;469777928&quot;:[1]}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Este proyecto ha sentado, adem\u00e1s,\u00a0las bases para la generaci\u00f3n c\u00e9lulas progenitoras de ri\u00f1\u00f3n\u00a0ya\u00a0que capturan el trasfondo gen\u00e9tico del\u00a0CcRCC\u00a0Gracias a los avances de este estudio, en un futuro los investigadores creen posible la realizaci\u00f3n de una plataforma de alto rendimiento para el estudio de la iniciaci\u00f3n de\u00a0CcRCC\u00a0utilizando\u00a0organoides\u00a0de ri\u00f1\u00f3n que ser\u00edan de gran utilidad para la industria farmac\u00e9utica.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:257,&quot;469777462&quot;:[3015],&quot;469777927&quot;:[0],&quot;469777928&quot;:[1]}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Sobre las \u201cAyudas LAB\u201d<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:257,&quot;469777462&quot;:[3015],&quot;469777927&quot;:[0],&quot;469777928&quot;:[1]}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Las \u201c<\/span><a href=\"https:\/\/www.aecc.es\/es\/area-investigador\/ayudas\/proyectos\/lab-2021\"><span data-contrast=\"none\">Ayudas LAB<\/span><\/a><span data-contrast=\"auto\">\u201d financian a grupos emergentes para llevar a cabo proyectos en c\u00e1ncer que tienen muchas posibilidades de ser trasladados a la pr\u00e1ctica cl\u00ednica. Se consideran grupos emergentes hasta 5 a\u00f1os despu\u00e9s de haber iniciado una l\u00ednea de investigaci\u00f3n independiente acreditado por su producci\u00f3n cient\u00edfica y\/o proyectos financiados.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:257,&quot;469777462&quot;:[3015],&quot;469777927&quot;:[0],&quot;469777928&quot;:[1]}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<h3>Un\u00a0proyecto capitaneado por\u00a0la\u00a0Profesora de Investigaci\u00f3n ICREA\u00a0en IBEC, N\u00faria Montserrat,\u00a0ha\u00a0dedicado\u00a0tres a\u00f1os\u00a0a la investigaci\u00f3n\u00a0al estudio del\u00a0c\u00e1ncer\u00a0renal\u00a0utilizando\u00a0organoides\u00a0de laboratorio,\u00a0gracias a las ayudas \u201cLAB 2017\u201d\u00a0de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer\u00a0(AECC).\u00a0Los investigadores han logrado crear el primer modelo\u00a0animal\u00a0basado\u00a0en\u00a0organoides\u00a0renales\u00a0para este tipo de c\u00e1ncer, y empezar a identificar\u00a0signos tempranos del desarrollo de la enfermedad.\u00a0<\/h3>\n","protected":false},"author":4,"featured_media":85927,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1519,1124],"post_formats":[],"class_list":["post-85926","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-aecc","tag-nuria-montserrat-es-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Los mini-\u00f3rganos de\u00a0bioingenier\u00eda\u00a0avanzan\u00a0en\u00a0la lucha contra el c\u00e1ncer gracias a la AECC\u00a0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/los-mini-organos-de-bioingenieria-avanzan-en-la-lucha-contra-el-cancer-gracias-a-la-aecc\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Los mini-\u00f3rganos de\u00a0bioingenier\u00eda\u00a0avanzan\u00a0en\u00a0la lucha contra el c\u00e1ncer gracias a la AECC\u00a0 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un\u00a0proyecto capitaneado por\u00a0la\u00a0Profesora de Investigaci\u00f3n ICREA\u00a0en IBEC, N\u00faria Montserrat,\u00a0ha\u00a0dedicado\u00a0tres a\u00f1os\u00a0a la investigaci\u00f3n\u00a0al estudio del\u00a0c\u00e1ncer\u00a0renal\u00a0utilizando\u00a0organoides\u00a0de 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