{"id":87033,"date":"2021-09-08T12:04:21","date_gmt":"2021-09-08T10:04:21","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=87033"},"modified":"2021-09-09T10:21:51","modified_gmt":"2021-09-09T08:21:51","slug":"un-nuevo-modelo-muscular-en-3d-permitira-estudiar-el-envejecimiento-y-evaluar-farmacos-y-cosmeticos","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/un-nuevo-modelo-muscular-en-3d-permitira-estudiar-el-envejecimiento-y-evaluar-farmacos-y-cosmeticos\/","title":{"rendered":"Un nuevo modelo muscular en 3D permitir\u00e1 estudiar el envejecimiento y evaluar f\u00e1rmacos y cosm\u00e9ticos"},"content":{"rendered":"

\"\"<\/p>\n

L<\/span>os estudios que utilizan modelos\u00a0<\/span><\/span>in vitro<\/span><\/span>\u00a0de tejidos musculares<\/span>,\u00a0<\/span>ya sea\u00a0<\/span>en\u00a0<\/span>bio<\/span>medicina<\/span>\u00a0o<\/span>\u00a0<\/span>en la industria cosm\u00e9tica,<\/span>\u00a0<\/span>se<\/span>\u00a0<\/span>basa<\/span>n<\/span>\u00a0<\/span>en gran medida\u00a0<\/span>en modelos 2D<\/span>\u00a0de crecimiento celular<\/span>, que no\u00a0<\/span>representan lo que realmente ocurre en el cuerpo humano.\u00a0<\/span>Existe,<\/span>\u00a0por tanto,<\/span>\u00a0una gran necesidad\u00a0<\/span>de modelos tridimensionales que permitan realizar estudios fiables y reproducibles\u00a0<\/span>en campos\u00a0<\/span>como\u00a0<\/span>la ingenier\u00eda de tejidos, la modelizaci\u00f3n de enfermedades<\/span>\u00a0y el testeo de nuevos f\u00e1rmacos,<\/span>\u00a0y la rob\u00f3tica bio-h\u00edbrida (combinaci\u00f3n de tejidos vivos y robots)<\/span>.<\/span><\/span>\u00a0<\/span><\/p>\n

 <\/p>\n

Ahora, g<\/span>racias<\/span>\u00a0a la ingenier\u00eda de tejidos y a la\u00a0<\/span>bioimpresi\u00f3n<\/span>\u00a03D<\/span>,<\/span>\u00a0<\/span>investigadores del\u00a0<\/span>Instituto de Bioingenier\u00eda de Catalunya (<\/span>IBEC<\/span>)<\/span>\u00a0liderados por Samuel S\u00e1nchez,\u00a0<\/span>Profesor de Investigaci\u00f3n ICREA e\u00a0<\/span>investigador principal del grupo\u00a0<\/span>\u201c<\/span><\/span>Nano-Bio Dispositivos Inteligentes<\/span><\/span><\/a>\u201d,\u00a0<\/span>h<\/span>a<\/span>n<\/span>\u00a0<\/span>desarrollado<\/span>\u00a0<\/span>una nueva plataforma 3D con m\u00fasculos esquel\u00e9ticos humanos<\/span>\u00a0que mimetiza el tejido real<\/span>.\u00a0<\/span><\/span>Este nuevo enfoque permitir\u00e1\u00a0<\/span>estudiar<\/span>\u00a0en detalle tanto el desarrollo de los m\u00fasculos como las enfermedades que padecen, adem\u00e1s de\u00a0<\/span>posibilitar una evaluaci\u00f3n fiable de f\u00e1rmacos y cosm\u00e9ticos<\/span><\/span><\/strong>.\u00a0<\/span>El trabajo<\/span>\u00a0<\/span>h<\/span>a sido\u00a0<\/span>realizado en colaboraci\u00f3n con la empresa\u00a0<\/span><\/span>Lubrizol<\/span><\/span><\/a>\u00a0<\/span>y\u00a0<\/span>se ha publicado recientemente\u00a0<\/span>en la revista\u00a0<\/span><\/span>Biofabrication<\/span><\/span><\/a>.\u00a0<\/span><\/span>\u00a0<\/span><\/span>\u00a0<\/span><\/p>\n

El nuevo modelo muscular en 3D<\/span><\/span>\u00a0<\/span> <\/span> <\/strong><\/h2>\n

El nuevo\u00a0modelo tridimensional de tejido muscular\u00a0desarrollado\u00a0por los investigadores del\u00a0IBEC es\u00a0capaz de mimetizar\u00a0la estructura 3D del tejido nativo. Adem\u00e1s, proporciona\u00a0informaci\u00f3n\u00a0cuantitativa\u00a0sobre la generaci\u00f3n de fuerza y los patrones de contracci\u00f3n<\/span>\u00a0<\/span><\/b>muscular\u00a0a trav\u00e9s de est\u00edmulos el\u00e9ctricos con electrodos de carbono fabricados por los\u00a0propios\u00a0investigadores.\u00a0<\/span>\u00a0<\/span><\/p>\n

Para generar\u00a0el nuevo m\u00fasculo, los investigadores partieron de mioblastos, precursores de\u00a0c\u00e9lulas musculares,\u00a0juntamente con\u00a0una mezcla\u00a0de\u00a0diferentes componentes que simula el medio extracelular\u00a0y\u00a0ayuda a dar forma y estructura 3D al nuevo tejido.<\/span>\u00a0<\/span><\/p>\n

\"\"
Esquema para generar el m\u00fasculo en 3D.<\/figcaption><\/figure>\n

La utilizaci\u00f3n de c\u00e9lulas humanas en la nueva plataforma, adem\u00e1s de\u00a0aportar fiabilidad y precisi\u00f3n, presenta otras ventajas como la posibilidad de personalizaci\u00f3n\u00a0partiendo de c\u00e9lulas de pacientes, y de prescindir de la utilizaci\u00f3n de animales para la experimentaci\u00f3n, eliminando las implicaciones \u00e9ticas que conlleva.<\/span>\u00a0<\/span><\/p>\n

Este modelo ofrece la versatilidad y flexibilidad necesarias en los enfoques multidisciplinarios para la comprensi\u00f3n del desarrollo muscular y de su respuesta a diferentes tratamientos.<\/span>\u00a0<\/span><\/p>\n

La nueva plataforma es id\u00f3nea para evaluar f\u00e1rmacos y cosm\u00e9ticos y entender c\u00f3mo afectan el m\u00fasculo y controlan su comportamiento.<\/span><\/span><\/strong><\/p>\n

Rafael Mestre, primer\u00a0<\/span>coautor del estudio<\/span><\/span><\/span>\u00a0(IBEC).\u00a0<\/strong><\/p>\n<\/blockquote>\n

Prueba de concepto: el envejecimiento muscular<\/span><\/span>\u00a0<\/span><\/strong><\/h2>\n

La posibilidad de estudiar el envejecimiento muscular en una plataforma 3D tiene mucha relevancia para la industria cosm\u00e9tica, ya que est\u00e1 \u00edntimamente relacionado con alteraciones funcionales y fisiol\u00f3gicas de los m\u00fasculos faciales. En la prueba de concepto para simular el envejecimiento muscular,\u00a0los investigadores utilizaron el factor de necrosis\u00a0tumoral-\u03b1\u00a0(TNF-\u00a0\u03b1),\u00a0una peque\u00f1a prote\u00edna del grupo de las citocinas,\u00a0relacionada, entre otros, con\u00a0la p\u00e9rdida de masa\u00a0y tono\u00a0muscular.\u00a0Al tratar el m\u00fasculo\u00a0con\u00a0TNF-\u00a0\u03b1, los investigadores\u00a0observaron\u00a0cambios en\u00a0la\u00a0relajaci\u00f3n y una reducci\u00f3n de la fuerza musculares, similar a lo que ocurre en un proceso real de envejecimiento.\u00a0\u00a0<\/span>\u00a0<\/span><\/p>\n

Finalmente,\u00a0para evaluar la funcionalidad muscular y el efecto de nuevos compuestos, los investigadores realizaron pruebas en\u00a0colaboraci\u00f3n con la empresa\u00a0Lubrizol.\u00a0La nueva plataforma permiti\u00f3 corroborar la eficacia de un nuevo producto cosm\u00e9tico antiarrugas,\u00a0Argireline\u00ae\u00a0Amplified\u00a0peptide, que\u00a0mostr\u00f3 una reducci\u00f3n en la fuerza de contracci\u00f3n muscular y una mayor relajaci\u00f3n. Desde entonces, el p\u00e9ptido ha sido introducido en el mercado con una velocidad excepcional, creando un inter\u00e9s masivo en clientes de todo el mundo, y consiguiendo estar presente ya en algunos productos finales del mercado.\u00a0<\/span>\u00a0<\/span><\/p>\n

Con nuestro modelo muscular en 3D podremos comprender aspectos clave de la funci\u00f3n muscular<\/span>\u00a0durante el envejecimiento y estudiar los procesos fisiol\u00f3gicos que contribuyen a la aparici\u00f3n de las arrugas de expresi\u00f3n, as\u00ed como las v\u00edas necesarias para reducirlas<\/span>.<\/strong><\/p>\n

Mauricio Valerio-Santiago, Lubrizol.\u00a0<\/strong><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

\n
\n

Art\u00edculo de referencia:<\/strong>\u00a0Rafael Mestre, Nerea Garc\u00eda, Tania Pati\u00f1o,\u00a0Maria\u00a0Guix, Judith Fuentes, Mauricio Valerio-Santiago, N\u00faria\u00a0Almi\u00f1ana, Samuel S\u00e1nchez.\u00a0<\/span>3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes<\/span><\/a>.\u00a0Biofabrication\u00a013 (2021) 045011.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadores del IBEC desarrollan un modelo tridimensional de tejido muscular mediante t\u00e9cnicas de bioimpresi\u00f3n y bioingenier\u00eda de tejidos que permite reproducir sus perfiles de fuerza, contracci\u00f3n y envejecimiento. El nuevo modelo tendr\u00e1 potenciales aplicaciones en campos como la biomedicina, la cosm\u00e9tica y la rob\u00f3tica. Adem\u00e1s, abrir\u00e1 las puertas al estudio de alteraciones morfol\u00f3gicas y funcionales causadas por el envejecimiento muscular. <\/h3>\n","protected":false},"author":4,"featured_media":87007,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1538,1537,1139],"post_formats":[],"class_list":["post-87033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-lubrizol-es","tag-modelo-muscular-3d","tag-samuel-sanchez-es"],"yoast_head":"\nUn nuevo modelo muscular en 3D permitir\u00e1 estudiar el envejecimiento y evaluar f\u00e1rmacos y cosm\u00e9ticos - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/un-nuevo-modelo-muscular-en-3d-permitira-estudiar-el-envejecimiento-y-evaluar-farmacos-y-cosmeticos\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un nuevo modelo muscular en 3D permitir\u00e1 estudiar el envejecimiento y evaluar f\u00e1rmacos y cosm\u00e9ticos - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC desarrollan un modelo tridimensional de tejido muscular mediante t\u00e9cnicas de bioimpresi\u00f3n y bioingenier\u00eda de tejidos que permite reproducir sus perfiles de fuerza, contracci\u00f3n y envejecimiento. 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