{"id":87187,"date":"2021-09-15T12:30:29","date_gmt":"2021-09-15T10:30:29","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=87187"},"modified":"2021-09-27T10:42:08","modified_gmt":"2021-09-27T08:42:08","slug":"un-chip-contra-las-infecciones-bacterianas-cronicas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/un-chip-contra-las-infecciones-bacterianas-cronicas\/","title":{"rendered":"Un chip contra las infecciones bacterianas cr\u00f3nicas\u00a0"},"content":{"rendered":"

\"\"El 80% de las infecciones cr\u00f3nicas se asocian al crecimiento de biofilms o biopel\u00edculas. Se trata de comunidades bacterianas de distintas especies que se forman y viven en superficies de tejidos vivos o inertes. Este tipo de infecciones son complejas, dif\u00edciles de tratar y suelen perdurar por un largo periodo de tiempo, ya que los biofilms est\u00e1n embebidos en una matriz que protege las bacterias de los tratamientos antimicrobianos y del sistema inmune, convirti\u00e9ndose as\u00ed mucho m\u00e1s resistentes a los antibi\u00f3ticos.<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span>A pesar de la importancia cl\u00ednica de las infecciones\u00a0producidas por\u00a0biofilms,\u00a0a\u00fan\u00a0no se ha descrito un m\u00e9todo simple y efectivo para\u00a0diagnosticar\u00a0su\u00a0susceptibilidad a antibi\u00f3ticos y\u00a0evaluar nuevas estrategias para su control y erradicaci\u00f3n.\u00a0<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span>Ahora,\u00a0investigadores del\u00a0Instituto de Bioingenier\u00eda de Catalunya (IBEC),\u00a0liderados por\u00a0Eduard Torrents,\u00a0investigador principal del grupo \u201c<\/span>Infecciones bacterianas y terapias antimicrobianas<\/span><\/a>\u201d\u00a0y profesor de la Universidad de Barcelona\u00a0(UB),\u00a0en colaboraci\u00f3n con\u00a0Josep Samitier,\u00a0investigador principal\u00a0del\u00a0grupo\u00a0\u201c<\/span>Nanobioingenier\u00eda<\/span><\/a>\u201d\u00a0del IBEC,\u00a0y\u00a0Maite Martin,\u00a0del\u00a0Hospital Universitario Vall d\u2019Hebron en Barcelona,\u00a0han\u00a0<\/span>desarrollado un novedoso dispositivo,\u00a0denominado\u00a0BiofilmChip,\u00a0que permite\u00a0un diagn\u00f3stico personalizado y preciso de las infecciones cr\u00f3nicas.<\/span><\/b>\u00a0Este trabajo ha sido publicado recientemente en la revista del grupo\u00a0Nature,\u00a0<\/span>Biofilms\u00a0and\u00a0Microbiomes<\/span><\/i><\/a>,<\/span><\/i>\u00a0<\/span><\/i>y cuenta con el apoyo de la Fundaci\u00f3n \u201cla Caixa\u201d\u00a0<\/span>para su desarrollo<\/span>.<\/span>.<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span>Este\u00a0nuevo\u00a0dispositivo\u00a0permitir\u00e1 hacer\u00a0crecer\u00a0biofilms<\/span>\u00a0<\/span><\/i>en el laboratorio\u00a0reproduciendo las condiciones\u00a0que\u00a0ocurren\u00a0durante el proceso de infecci\u00f3n. As\u00ed, se\u00a0podr\u00e1\u00a0determinar su patr\u00f3n de resistencia\u00a0y sensibilidad a diferentes antibi\u00f3ticos e\u00a0identificar\u00a0el tratamiento\u00a0m\u00e1s\u00a0adecuado, incluso de forma personalizada a cada paciente.\u00a0<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span>El\u00a0BiofilmChip\u00a0abre las puertas al estudio y tratamiento de\u00a0biofilms,\u00a0tanto\u00a0en infecciones cr\u00f3nicas como la fibrosis qu\u00edstica e infecciones pulmonares\u00a0o urinarias,\u00a0como\u00a0en \u00e1mbitos\u00a0relacionados con\u00a0las contaminaciones de material hospitalario (cat\u00e9teres, v\u00e1lvulas card\u00edacas y pr\u00f3tesis) o en la industria alimentaria (superficies y planos de trabajo).\u00a0<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

BiofilmChip: una nueva forma de luchar contra las infecciones producidas por\u00a0biofilms<\/span><\/b>\u00a0<\/span><\/p>\n

\u00a0<\/span>El mal uso de los antibi\u00f3ticos sumado a las infecciones cr\u00f3nicas\u00a0producidas por\u00a0biofilms,\u00a0est\u00e1 llevando\u00a0a un aumento de las\u00a0resistencias bacterianas.\u00a0Hasta la fecha no se ha descrito ning\u00fan antibi\u00f3tico capaz de erradicar los\u00a0biofilms, entre otras cosas por la falta de un sistema\u00a0<\/span>in vitro<\/span><\/i>\u00a0realmente efectivo\u00a0que permita la\u00a0investigaci\u00f3n y el desarrollo de nuevas\u00a0mol\u00e9culas\u00a0antibiofilm.<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span>El\u00a0BiofilmChip\u00a0permite el cultivo del\u00a0biofilm\u00a0como tal, con toda la comunidad bacteriana que lo compone, a diferencia de los m\u00e9todos cl\u00e1sicos de microbiolog\u00eda donde se cultivan las bacterias por separado en placas individuales. Este punto es crucial, ya que las bacterias presentan susceptibilidades muy distintas al mismo antibi\u00f3tico si se encuentran aisladas o formando parte de un\u00a0biofilm.\u00a0<\/span>\u00a0<\/span><\/p>\n

Nuestro BiofilmChip permite evaluar la acci\u00f3n de diferentes antibi\u00f3ticos directamente sobre un biofilm, aproxim\u00e1ndose mucho m\u00e1s a lo que ocurre en infecciones reales.<\/span><\/i>\u00a0<\/span><\/p>\n

 <\/p>\n

N\u00faria Blanco-Cabra,\u00a0coautora principal del estudio<\/span><\/i>\u00a0<\/span><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

En colaboraci\u00f3n con el Hospital Vall d\u2019Hebron, los investigadores han hecho crecer en\u00a0el\u00a0BiofilmChip\u00a0las bacterias contenidas en muestras de esputo de pacientes con fibrosis qu\u00edstica. El\u00a0BiofilmChip\u00a0es\u00a0una plataforma de\u00a0microflu\u00eddica\u00a0que permite llevar al\u00a0biofilm\u00a0no solo los nutrientes y compuestos necesarios para su crecimiento,\u00a0sino\u00a0tambi\u00e9n los diferentes antibi\u00f3ticos que se quieran analizar.\u00a0<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span>En este dispositivo\u00a0se\u00a0ha\u00a0integrado\u00a0un electrodo\u00a0que\u00a0permite determinar\u00a0el crecimiento bacteriano\u00a0y la respuesta del\u00a0biofilm\u00a0a un antibi\u00f3tico\u00a0o tratamiento,\u00a0mediante la detecci\u00f3n\u00a0de par\u00e1metros el\u00e9ctricos (impedancia).\u00a0Al mismo tiempo, el\u00a0dispositivo permite la observaci\u00f3n\u00a0del\u00a0biofilm\u00a0al microscopio sin\u00a0previa manipulaci\u00f3n.\u00a0La utilizaci\u00f3n del\u00a0BiofilmChip\u00a0es\u00a0simple\u00a0y\u00a0no requiere una infraestructura compleja para su funcionamiento, de\u00a0modo\u00a0que se podr\u00eda\u00a0emplear\u00a0de forma rutinaria en los laboratorios de microbiolog\u00eda cl\u00ednica\u00a0o en la industria.\u00a0<\/span>\u00a0<\/span><\/p>\n

Los resultados que obtuvimos con el BiofilmChip demuestran que es una herramienta muy \u00fatil para determinar la susceptibilidad de biofilms a antibi\u00f3ticos y que se podr\u00eda implementar f\u00e1cilmente en los hospitales.<\/span><\/i><\/p>\n

 <\/p>\n

Maria Jos\u00e9 L\u00f3pez-Mart\u00ednez,\u00a0coautora principal del estudio<\/span><\/i>\u00a0<\/span><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

Art\u00edculo\u00a0de referencia:<\/span><\/b>\u00a0<\/span>\u00a0<\/span><\/p>\n

N\u00faria Blanco-Cabra, Maria Jos\u00e9 L\u00f3pez-Mart\u00ednez, Betsy Ver\u00f3nica Ar\u00e9valo-Jaimes, Mar\u00eda Teresa Martin-G\u00f3mez, Josep Samitier, Eduard Torrents.\u00a0<\/span>A new\u00a0BiofilmChip\u00a0device for testing biofilm formation and antibiotic susceptibility<\/span><\/a>.\u00a0npj\u00a0Biofilms and Microbiomes (2021) 7:62.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadores del IBEC desarrollan un dispositivo que permite crecer\u00a0biofilms\u00a0y\u00a0analizar\u00a0su susceptibilidad frente a diferentes antibi\u00f3ticos\u00a0de forma sencilla\u00a0y\u00a0a partir de muestras de pacientes. El innovador\u00a0BiofilmChip, un dispositivo\u00a0de diagn\u00f3stico\u00a0de f\u00e1cil utilizaci\u00f3n y bajo coste,\u00a0abre las puertas a encontrar tratamientos efectivos y personalizados\u00a0contra\u00a0infecciones cr\u00f3nicas\u00a0producidas por\u00a0biofilms.\u00a0<\/h3>\n

.<\/p>\n","protected":false},"author":4,"featured_media":87209,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1332,1540,1142,1137],"post_formats":[],"class_list":["post-87187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-antibioticos","tag-chip","tag-eduard-torrents-es","tag-josep-samitier-es"],"yoast_head":"\nUn chip contra las infecciones bacterianas cr\u00f3nicas\u00a0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/un-chip-contra-las-infecciones-bacterianas-cronicas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un chip contra las infecciones bacterianas cr\u00f3nicas\u00a0 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC desarrollan un dispositivo que permite crecer\u00a0biofilms\u00a0y\u00a0analizar\u00a0su susceptibilidad frente a diferentes antibi\u00f3ticos\u00a0de forma sencilla\u00a0y\u00a0a partir de muestras de pacientes. 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