{"id":88505,"date":"2021-11-12T06:13:18","date_gmt":"2021-11-12T05:13:18","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=88505"},"modified":"2021-11-12T14:22:58","modified_gmt":"2021-11-12T13:22:58","slug":"logran-recuperar-la-movilidad-en-ratones-con-graves-lesiones-medulares-mediante-una-inyeccion-de-nanofibras","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/logran-recuperar-la-movilidad-en-ratones-con-graves-lesiones-medulares-mediante-una-inyeccion-de-nanofibras\/","title":{"rendered":"Logran recuperar la movilidad en ratones con graves lesiones medulares mediante una inyecci\u00f3n de nanofibras"},"content":{"rendered":"<figure id=\"attachment_88541\" aria-describedby=\"caption-attachment-88541\" style=\"width: 765px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"wp-image-88541 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Image-5-from-Figure-1-300x146.jpg\" alt=\"\" width=\"775\" height=\"376\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 775px; --smush-placeholder-aspect-ratio: 775\/376;\" \/><figcaption id=\"caption-attachment-88541\" class=\"wp-caption-text\"><span class=\"NormalTextRun SCXW23367109 BCX8\">Secci\u00f3n longitudinal de la m\u00e9dula espinal tratada con<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">\u00a0las\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2 SCXW23367109 BCX8\">nanofibras<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">\u00a0sint\u00e9ticas bioactiv<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">as<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">. Los axones regenerados (rojo) volvieron a crecer dentro de la lesi\u00f3n.<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">\u00a0Cr\u00e9dito:\u00a0<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">Samuel I.\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2 SCXW23367109 BCX8\">Stupp<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2 SCXW23367109 BCX8\">Laboratory<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">\/<\/span><span class=\"NormalTextRun SpellingErrorV2 SCXW23367109 BCX8\">Northwestern<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2 SCXW23367109 BCX8\">University<\/span><span class=\"NormalTextRun SCXW23367109 BCX8\">.<\/span><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p><span class=\"TextRun SCXW210093354 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">Investigadores liderados por el\u00a0<\/span><\/span><span class=\"TextRun Highlight SCXW210093354 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">Profesor<\/span><\/span><span class=\"TextRun SCXW210093354 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">\u00a0Samuel\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2 SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">Stupp<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">, de la Universidad de\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2 SCXW210093354 BCX8 SpellingErrorHighlight\" data-ccp-parastyle=\"No Spacing\">Northwester<\/span><span class=\"NormalTextRun SpellingErrorV2 SCXW210093354 BCX8 SpellingErrorHighlight\" data-ccp-parastyle=\"No Spacing\">n<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">\u00a0(EE<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">.<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">\u00a0<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">UU<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">.<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">) y\u00a0<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">tambi\u00e9n\u00a0<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">Profesor Distinguido\u00a0Severo Ochoa<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">\u00a0<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">en el IBEC<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">, y con participaci\u00f3n de Zaida\u00a0<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">\u00c1lvarez Pinto<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">,\u00a0<\/span><\/span><span class=\"TextRun Highlight SCXW210093354 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">actual<\/span><\/span><span class=\"TextRun SCXW210093354 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">\u00a0<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">investigadora del grupo \u201c<\/span><\/span><a class=\"Hyperlink SCXW210093354 BCX8\" href=\"https:\/\/ibecbarcelona.eu\/biomaterials\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun Underlined SCXW210093354 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-charstyle=\"Hyperlink\">Biomateriales para Terapias Regenerativas<\/span><\/span><\/a><span class=\"TextRun SCXW210093354 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">\u201d en el IBEC, un centro CERCA, <\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">han desarrollado una nueva terapia inyectable que\u00a0<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">usa<\/span><span class=\"NormalTextRun SCXW210093354 BCX8\" data-ccp-parastyle=\"No Spacing\">\u00a0\u00abmol\u00e9culas danzantes\u00bb para revertir la par\u00e1lisis y reparar el tejido despu\u00e9s de lesiones graves de la m\u00e9dula espinal.<\/span><\/span><span class=\"EOP SCXW210093354 BCX8\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">En un\u00a0trabajo\u00a0pionero\u00a0<\/span><span data-contrast=\"none\">realizado en la Universidad de\u00a0Northwestern,\u00a0con \u00c1lvarez Pinto como primera autora,<\/span><span data-contrast=\"none\">\u00a0y\u00a0publicado\u00a0en la prestigiosa revista\u00a0<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abh3602\" target=\"_blank\" rel=\"noopener\">Science<\/a>,\u00a0los investigadores administraron una sola inyecci\u00f3n\u00a0de\u00a0nanofibras\u00a0en\u00a0la m\u00e9dula espinal\u00a0de ratones paralizados. Solo cuatro semanas despu\u00e9s, los animales recuperaron la capacidad de caminar.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Una vez que la terapia realiza su funci\u00f3n, los materiales se biodegradan\u00a0en 12 semanas\u00a0en nutrientes para las c\u00e9lulas\u00a0y luego desaparecen por completo del cuerpo sin efectos secundarios notables.\u00a0<\/span><b><span data-contrast=\"none\">Este es el primer estudio en el que investigadores controlaron el movimiento colectivo de mol\u00e9culas a trav\u00e9s de cambios en la estructura qu\u00edmica\u00a0de las\u00a0nanofibras\u00a0para aumentar la eficacia terap\u00e9utica.<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><iframe title=\"Severe spinal cord injuries repaired with &#039;dancing molecules&#039;\" width=\"1200\" height=\"675\" data-src=\"https:\/\/www.youtube.com\/embed\/Q_xvCE904YU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" data-load-mode=\"1\"><\/iframe><\/p>\n<h4><strong>La esperanza de vida no ha mejorado desde 1980<\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"none\">Seg\u00fan el Centro Nacional de Estad\u00edsticas de Lesiones de la M\u00e9dula Espinal, casi 300.000 personas viven actualmente con\u00a0alg\u00fan\u00a0tipo de\u00a0lesi\u00f3n de\u00a0m\u00e9dula espinal en los\u00a0EEUU. Menos del 3% de las\u00a0que sufren\u00a0lesiones completas recuperan las funciones f\u00edsicas b\u00e1sicas\u00a0y cerca del\u00a030% son reingresados \u200b\u200bal menos una vez,\u00a0lo que conlleva a un coste\u00a0muy elevado en atenci\u00f3n sanitaria de por vida.\u00a0Adem\u00e1s, la esperanza de vida\u00a0se reduce significativamente\u00a0y no ha mejorado desde la d\u00e9cada de\u00a0los 80.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u201cActualmente, no existen terapias que desencadenen la regeneraci\u00f3n de la m\u00e9dula espinal\u201d,\u00a0seg\u00fan\u00a0Stupp, experto en medicina regenerativa\u00a0<\/span><span data-contrast=\"none\">y D<\/span><span data-contrast=\"auto\">irector\u00a0del\u00a0<\/span><span data-contrast=\"none\">Simpson Querrey\u00a0Institute\u00a0for\u00a0BioNanotechnology\u00a0<\/span><span data-contrast=\"none\">de la Universidad de\u00a0Northwestern\u00a0en\u00a0Chicago<\/span><span data-contrast=\"none\">.<\/span><span data-contrast=\"none\">\u00a0\u201cQuer\u00eda\u00a0enfocar el trabajo en las consecuencias de\u00a0una\u00a0lesi\u00f3n de\u00a0m\u00e9dula espinal y abordar este problema, dado el tremendo impacto que podr\u00eda tener en la vida de los pacientes. Adem\u00e1s,\u00a0una nueva\u00a0ciencia para abordar la lesi\u00f3n de la m\u00e9dula espinal podr\u00eda tener un impacto en las estrategias para\u00a0tratar\u00a0las enfermedades neurodegenerativas y los accidentes cerebrovasculares\u201d.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">El objetivo del estudio\u00a0ha sido encontrar\u00a0una terapia que pueda evitar que las personas\u00a0queden paraliticas\u00a0despu\u00e9s de un trauma o enfermedad grave\u00a0en la m\u00e9dula espinal.\u00a0Durante d\u00e9cadas, esto ha sido un gran desaf\u00edo para los cient\u00edficos porque el sistema nervioso central, que incluye el cerebro y la m\u00e9dula espinal, no tiene ninguna capacidad significativa para repararse despu\u00e9s de una lesi\u00f3n o despu\u00e9s del inicio de una enfermedad degenerativa.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"wp-image-88506 alignleft lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Stupp-new-portrait-258x300.jpg\" alt=\"\" width=\"280\" height=\"326\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Stupp-new-portrait-258x300.jpg 258w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Stupp-new-portrait-879x1024.jpg 879w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Stupp-new-portrait-768x895.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Stupp-new-portrait-1319x1536.jpg 1319w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Stupp-new-portrait-1758x2048.jpg 1758w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Stupp-new-portrait-129x150.jpg 129w\" data-sizes=\"(max-width: 280px) 100vw, 280px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 280px; --smush-placeholder-aspect-ratio: 280\/326;\" \/><\/p>\n<h4><em>\u00abVamos a ir directamente a la Agencia de Administraci\u00f3n de Alimentos y Medicamentos en EE. UU. para iniciar el proceso de aprobaci\u00f3n de esta nueva terapia para su uso en pacientes humanos, que actualmente tienen muy pocas opciones de tratamiento\u00bb.<\/em><\/h4>\n<h5><em>Samuel I. Stupp de la Universidad de Northwestern, tambi\u00e9n es Profesor Distinguido Severo Ochoa en IBEC.<\/em><\/h5>\n<p>&nbsp;<\/p>\n<h4><\/h4>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"none\">Las\u00a0c\u00e9lulas\u00a0y sus receptores est\u00e1n en constante movimiento,\u00a0de forma que lo que los investigadores han imaginado es que si\u00a0las mol\u00e9culas\u00a0usadas en el tratamiento\u00a0se mueven m\u00e1s r\u00e1pidamente encontrar\u00e1n\u00a0estos receptores con m\u00e1s frecuencia. Por otro lado,\u00a0mol\u00e9culas lentas y no tan &#8216;sociables&#8217;,\u00a0probablemente\u00a0nunca entraran en contacto con\u00a0los receptores de\u00a0las c\u00e9lulas.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Inyectada como un l\u00edquido, la terapia se gelifica inmediatamente en una compleja red de\u00a0nanofibras\u00a0que imitan la matriz extracelular de la m\u00e9dula espinal. Al hacer coincidir la estructura de la matriz, imitar el movimiento de las mol\u00e9culas biol\u00f3gicas e incorporar se\u00f1ales para los receptores, los materiales sint\u00e9ticos pueden comunicarse con las c\u00e9lulas.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<h4><img decoding=\"async\" class=\"wp-image-88509 alignleft lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Zaida-portrait-300x228.jpg\" alt=\"\" width=\"323\" height=\"245\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Zaida-portrait-300x228.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Zaida-portrait-1024x778.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Zaida-portrait-768x583.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Zaida-portrait-150x114.jpg 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Zaida-portrait.jpg 1500w\" data-sizes=\"(max-width: 323px) 100vw, 323px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 323px; --smush-placeholder-aspect-ratio: 323\/245;\" \/><em>\u00abEl secreto detr\u00e1s de este nuevo y revolucionario tratamiento terap\u00e9utico es sintonizar el movimiento de las mol\u00e9culas para que puedan encontrar y activar adecuadamente los receptores celulares en constante movimiento\u00bb.<\/em><\/h4>\n<h5><em>Zaida \u00c1lvarez Pinto, primera autora del trabajo, actual investigadora del IBEC.<\/em><\/h5>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"none\">\u201cLa innovaci\u00f3n clave en nuestra investigaci\u00f3n, que nunca se hab\u00eda hecho antes, es controlar el movimiento colectivo de m\u00e1s de 100.000 mol\u00e9culas dentro de nuestras\u00a0nanofibras. Al hacer que las mol\u00e9culas se muevan, \u00abbailen\u00bb o incluso salten temporalmente de estas estructuras, conocidas como pol\u00edmeros supramoleculares, pueden conectarse de manera m\u00e1s eficaz con los receptores\u00a0de las c\u00e9lulas, que se\u00a0mueven constantemente\u00a0\u00ab, explica\u00a0Stupp.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Stupp\u00a0y su equipo encontraron que ajustar el movimiento de las mol\u00e9culas dentro de la red de\u00a0nanofibras\u00a0para hacerlas m\u00e1s \u00e1giles result\u00f3 en una mayor eficacia terap\u00e9utica en ratones paralizados. Tambi\u00e9n confirmaron que las formulaciones de su terapia con movimiento molecular\u00a0perfeccionado\u00a0funcionaron mejor durante las pruebas\u00a0<\/span><i><span data-contrast=\"none\">in vitro<\/span><\/i><span data-contrast=\"none\">\u00a0con c\u00e9lulas humanas, lo que indica una mayor bioactividad y se\u00f1alizaci\u00f3n celular.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<h4><strong>Una inyecci\u00f3n,\u00a0varias\u00a0se\u00f1ales<\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"none\">Al enviar se\u00f1ales bioactivas para hacer que\u00a0el tejido\u00a0se repare\u00a0y\u00a0se\u00a0regenere, la terapia revolucionaria mejor\u00f3 dr\u00e1sticamente\u00a0la m\u00e9dula espinal gravemente lesionada.\u00a0Una vez conectadas a los receptores, las mol\u00e9culas en movimiento desencadenan se\u00f1ales en cascada, cr\u00edticas para la reparaci\u00f3n de la m\u00e9dula espinal.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Por un lado, inducen\u00a0la regeneraci\u00f3n de\u00a0los axones de las neuronas de\u00a0la\u00a0m\u00e9dula\u00a0lesionadas.\u00a0Al igual que los cables el\u00e9ctricos, los axones env\u00edan se\u00f1ales entre el cerebro y el resto del cuerpo, y si sufren cortes o da\u00f1os se provoca\u00a0la p\u00e9rdida de sensibilidad en el cuerpo o incluso la par\u00e1lisis.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Por otro lado,\u00a0ayuda\u00a0a las neuronas a sobrevivir despu\u00e9s de\u00a0la\u00a0lesi\u00f3n, hace\u00a0proliferar otros tipos\u00a0celulares\u00a0y\u00a0promueve\u00a0el crecimiento de los vasos sangu\u00edneos perdidos que alimentan las neuronas y las c\u00e9lulas cr\u00edticas para la reparaci\u00f3n de los tejidos. La terapia tambi\u00e9n induce\u00a0la reconstrucci\u00f3n de la mielina alrededor de los axones\u00a0(la capa aislante importante para transmitir las se\u00f1ales el\u00e9ctricas)\u00a0y\u00a0reduce\u00a0el tejido\u00a0que act\u00faa como\u00a0barrera f\u00edsica\u00a0para\u00a0que\u00a0la m\u00e9dula espinal se cure.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Las se\u00f1ales utilizadas en el estudio imitan las prote\u00ednas naturales que se necesitan para inducir las respuestas biol\u00f3gicas deseadas. Sin embargo, las prote\u00ednas tienen vidas medias extremadamente cortas y su producci\u00f3n\u00a0es muy cara.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u201cNuestras se\u00f1ales sint\u00e9ticas son\u00a0prote\u00ednas\u00a0cortas y modificadas que, cuando se unen entre s\u00ed,\u00a0tendr\u00e1n\u00a0bioactividad\u00a0durante semanas\u00a0en el tejido. El resultado final es una terapia que es menos costosa de producir y dura mucho m\u00e1s, explica\u00a0Zaida \u00c1lvarez\u00a0Pinto, primera autora del trabajo e investigadora del IBEC.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<h4><strong>Aplicaci\u00f3n universal<\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"none\">Si bien la nueva terapia podr\u00eda usarse para prevenir la par\u00e1lisis despu\u00e9s de un trauma mayor (accidentes automovil\u00edsticos, ca\u00eddas, accidentes deportivos y heridas de bala), as\u00ed como de enfermedades,\u00a0probablemente\u00a0el descubrimiento subyacente,\u00a0relacionado con el\u00a0\u00abmovimiento supramolecular\u00bb\u00a0como\u00a0un factor clave en la bioactividad, puede ser aplicado a otras terapias y dianas.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u00abLos tejidos del sistema nervioso central que hemos regenerado con \u00e9xito en la m\u00e9dula espinal lesionada son similares a los del cerebro afectados por accidentes cerebrovasculares y enfermedades neurodegenerativas, como la ELA, la enfermedad de Parkinson y la enfermedad de Alzheimer\u00bb,\u00a0explica\u00a0Stupp. \u00abM\u00e1s all\u00e1 de eso, nuestro descubrimiento fundamental sobre el control del movimiento de los ensamblajes moleculares para mejorar la se\u00f1alizaci\u00f3n celular podr\u00eda aplicarse universalmente a\u00a0diferentes\u00a0objetivos biom\u00e9dicos\u00bb, concluye.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b><span data-contrast=\"none\">Art\u00edculo de referencia:\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\"><br \/>\n<\/span><span data-contrast=\"none\">Zaida Alvarez, Alexandra N. Kolberg-Edelbrock, Ivan R. Sasselli, J.Alberto Ortega, Ruomeng Qiu, Zois Syrgiannis, Peter A. Mirau, Feng Chen, Stacey M. Chin, Steven Weigand, Evangelos Kiskinis, Samuel I. Stupp. <\/span><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abh3602\" target=\"_blank\" rel=\"noopener\">Bioactive\u00a0scaffolds\u00a0with\u00a0enhanced\u00a0supramolecular\u00a0motion\u00a0promote\u00a0recovery\u00a0from\u00a0spinal\u00a0cord\u00a0injury<\/a><b><span data-contrast=\"none\">.<\/span><\/b><span data-contrast=\"none\"> Science, 2021, Vol 374 (6569), pp.848-856.<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Sobre\u00a0Samuel I.\u00a0Stupp:<br \/>\n<\/span><\/b><span data-contrast=\"none\">S<\/span><span data-contrast=\"auto\">amuel\u00a0Stupp\u00a0es\u00a0Profesor de la\u00a0<\/span><span data-contrast=\"auto\">Universidad\u00a0Northwestern\u00a0en Chicago, EE. UU,\u00a0y Profesor\u00a0<\/span><span data-contrast=\"auto\">Distinguido<\/span><span data-contrast=\"none\">\u00a0Severo Ochoa en el IBEC.\u00a0Tambi\u00e9n es\u00a0<\/span><span data-contrast=\"none\">miembro\u00a0de la Junta de\u00a0Consejeros\u00a0de\u00a0Ciencia\u00a0e\u00a0Ingenier\u00eda\u00a0de\u00a0Materiales,\u00a0Qu\u00edmica,\u00a0Medicina\u00a0e\u00a0Ingenier\u00eda\u00a0Biom\u00e9dica,\u00a0y\u00a0e<\/span><span data-contrast=\"auto\">s el director fundador del\u00a0<\/span><a href=\"https:\/\/sqi.northwestern.edu\/index.html\"><span data-contrast=\"none\">Simpson Querrey\u00a0Institute\u00a0for\u00a0BioNanotechnology<\/span><\/a><span data-contrast=\"none\">\u202f(SQI)\u00a0y de su centro de investigaci\u00f3n afiliado, el\u00a0<\/span><a href=\"https:\/\/crn.northwestern.edu\/\"><span data-contrast=\"none\">Center\u00a0for\u00a0Regenerative\u00a0Nanomedicine<\/span><\/a><span data-contrast=\"none\">,\u00a0<\/span><span data-contrast=\"none\">centrados en la investigaci\u00f3n interdisciplinarian, y tambi\u00e9n del Center for Bio-Inspired Energy Science, un Centro Puntero en Investigaciones Energ\u00e9ticas financiado por el Departamento de Energ\u00eda de EE. UU. <\/span><span data-contrast=\"none\">Tiene puestos en<\/span><a href=\"https:\/\/www.mccormick.northwestern.edu\/\"><span data-contrast=\"none\"> McCormick\u00a0School\u00a0of\u00a0Engineering<\/span><\/a><span data-contrast=\"none\">,\u202f<\/span><a href=\"https:\/\/weinberg.northwestern.edu\/\"><span data-contrast=\"none\">Weinberg\u00a0College\u00a0of\u00a0Arts\u00a0and\u00a0Sciences<\/span><\/a><span data-contrast=\"none\">\u202fy la\u202f<\/span><a href=\"https:\/\/www.feinberg.northwestern.edu\/\"><span data-contrast=\"none\">Feinberg\u00a0School\u00a0of\u00a0Medicine<\/span><\/a><span data-contrast=\"none\">.\u00a0Adem\u00e1s,\u00a0Stupp\u00a0<\/span><span data-contrast=\"none\">tambi\u00e9n\u00a0es\u00a0miembro\u00a0de la Academia Nacional de Ingenier\u00eda, la Academia\u00a0Estadounidense\u00a0de Artes y\u00a0Ciencias, la Real Academia Espa\u00f1ola y la Academia Nacional de\u00a0Inventores. Samuel Stupp es Director del\u00a0Comit\u00e9\u00a0Cient\u00edfico\u00a0(ISC) del\u00a0IBEC\u00a0desde\u00a02013.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Sobre\u00a0Zaida \u00c1lvarez Pint<\/span><\/b><span data-contrast=\"none\"><strong>o<\/strong>:<br \/>\nRealiz\u00f3 su tesis doctoral en biomateriales para la reparaci\u00f3n de da\u00f1os cerebrales en la UPC\/IBEC 2009-2014. Durante el periodo 2015-2019, hizo una estancia postdoctoral en el Simpson Querrey Institute for BioNanotechnology de la Northwestern University en Chicago. Del 2019-2021 fue Research Assistant Professor en la Escuela de Medicina Feinberg Medical School en la Northwestern University.\u00a0\u00a0Recientemente, como investigadora con una beca \u201cBeatriu de Pin\u00f3s\u201d en el instituto de Bioengenier\u00eda de Catalunya (IBEC), un centro CERCA, ha obtenido una \u201cRam\u00f3n y Cajal\u201d para seguir investigando sobre nuevas terapias para la reparaci\u00f3n de la m\u00e9dula espinal da\u00f1ada. \u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<h3> Investigadores\u00a0de la Universidad de\u00a0Northwestern, en\u00a0EE.\u00a0UU,\u00a0y del Instituto de Bioingenier\u00eda de\u00a0Catalunya (IBEC), desarrollan una nueva terapia inyectable que\u00a0utiliza\u00a0nanofibras\u00a0sint\u00e9ticas\u00a0para reparar lesiones medulares.\u00a0Las nanofibras, que contienen \u201cmol\u00e9culas danzantes\u201d, estimulan eficazmente los receptores celulares promoviendo la regeneraci\u00f3n medular. Despu\u00e9s de una sola inyecci\u00f3n, animales paralizados tratados con esta nueva terapia volvieron a caminar en tan solo cuatro semanas. El art\u00edculo ha sido publicado en\u00a0Science.\u00a0<\/h3>\n","protected":false},"author":24,"featured_media":88541,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[408,1552],"post_formats":[],"class_list":["post-88505","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-lesion-medular","tag-medula-espinal"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Logran recuperar la movilidad en ratones con graves lesiones medulares mediante una inyecci\u00f3n de nanofibras - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/logran-recuperar-la-movilidad-en-ratones-con-graves-lesiones-medulares-mediante-una-inyeccion-de-nanofibras\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Logran recuperar la movilidad en ratones con graves lesiones medulares mediante una inyecci\u00f3n de nanofibras - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores\u00a0de la Universidad de\u00a0Northwestern, en\u00a0EE.\u00a0UU,\u00a0y del Instituto de Bioingenier\u00eda de\u00a0Catalunya (IBEC), desarrollan una nueva terapia inyectable que\u00a0utiliza\u00a0nanofibras\u00a0sint\u00e9ticas\u00a0para reparar lesiones medulares.\u00a0Las nanofibras, que contienen \u201cmol\u00e9culas danzantes\u201d, estimulan eficazmente los receptores celulares promoviendo la regeneraci\u00f3n medular. Despu\u00e9s de una sola inyecci\u00f3n, animales paralizados tratados con esta nueva terapia volvieron a caminar en tan solo cuatro semanas. 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