{"id":88644,"date":"2021-11-02T11:50:43","date_gmt":"2021-11-02T10:50:43","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=88644"},"modified":"2021-11-16T11:07:02","modified_gmt":"2021-11-16T10:07:02","slug":"nuevo-biosensor-con-alta-sensibilidad-detecta-marcador-inflamatorio-en-musculo","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/nuevo-biosensor-con-alta-sensibilidad-detecta-marcador-inflamatorio-en-musculo\/","title":{"rendered":"Nuevo biosensor con alta sensibilidad detecta marcador inflamatorio en m\u00fasculo"},"content":{"rendered":"
\"\"
Izquierda: Fotograf\u00eda de un sustrato de disco Blu-<\/span>r<\/span>ay evaporado de Au de 70 nm y la difracci\u00f3n caracter\u00edstica de la luz. Derecha: Im\u00e1genes representativas de microscop\u00eda\u00a0<\/span>confocal<\/span>\u00a0de\u00a0<\/span>microt<\/span>ejidos<\/span>\u00a0de m\u00fasculo esquel\u00e9tico en 3D.<\/span><\/span>\u00a0<\/span><\/figcaption><\/figure>\n

\u00bfQu\u00e9 tienen en com\u00fan enfermedades como el c\u00e1ncer, la artritis reumatoide, la diabetes,\u00a0la COVID-19, la depresi\u00f3n o la distrofia muscular? A pesar de sus profundas diferencias, cada una\u00a0de ellas\u00a0est\u00e1 relacionada\u00a0con procesos inflamatorios desencadenados por un culpable com\u00fan: la interleucina-6 (IL-6). Esta biomol\u00e9cula pertenece a una amplia familia de prote\u00ednas conocidas\u00a0como citocinas, que participan en la respuesta inmunitaria del organismo. Dado que sus niveles suelen estar elevados en infecciones, inflamaciones\u00a0y enfermedades autoinmunes, es un indicador fiable de la gravedad\u00a0en numerosos casos. Por\u00a0lo contrario,\u00a0niveles reducidos pueden mostrar hasta qu\u00e9 punto est\u00e1 funcionando un tratamiento. Por lo tanto, ser capaz de medir citocinas como IL-6 de forma r\u00e1pida y precisa es crucial\u00a0para descubrir y testear\u00a0f\u00e1rmacos.\u00a0Sin embargo, desafortunadamente a menudo es dif\u00edcil hacerlo ya que est\u00e1 presente en concentraciones extremadamente bajas.<\/span>\u00a0<\/span><\/p>\n

Ahora, investigadores del grupo\u00a0<\/span>Biosensores para Bioingenier\u00eda<\/span><\/a>\u00a0del\u00a0IBEC presentan, en un nuevo estudio publicado en la revista<\/span>\u00a0<\/span>Nanophotonics,\u00a0<\/span><\/i>el empleo de la\u00a0nanoingenier\u00eda\u00a0para la detecci\u00f3n r\u00e1pida, precisa, f\u00e1cilmente reproducible y rentable de IL-6. El estudio fue\u00a0liderado por\u00a0el\u00a0jefe\u00a0del grupo\u00a0<\/span>Javier Ram\u00f3n Azc\u00f3n<\/span><\/a>, firmado por\u00a0el investigador postdoctoral\u00a0<\/span>Gerardo L\u00f3pez Mu\u00f1oz<\/span><\/a>\u00a0como primer autor, y\u00a0con las contribuciones de\u00a0Trias\u00a0y Eduard Martin-Lasierra, y\u00a0de los miembros del grupo\u00a0<\/span>Juanma Fern\u00e1ndez Costa<\/span><\/a>,\u00a0<\/span>Maria Alejandra Ortega Machuca<\/span><\/a>\u00a0y\u00a0Jordina\u00a0Balaguer.\u00a0<\/span>\u00a0<\/span><\/p>\n

Mejorando la sensibilidad y la reproducibilidad<\/span><\/span>\u00a0<\/span><\/strong><\/h3>\n

En este trabajo, se desarroll\u00f3 un nuevo biosensor basado en Blu-ray producido industrialmente para detectar la prote\u00edna IL-6 en m\u00fasculos esquel\u00e9ticos obtenidos por bioingenier\u00eda 3D. En primer lugar, los investigadores realizaron bioingenier\u00eda de tejidos musculares esquel\u00e9ticos en 3D mediante el uso de una t\u00e9cnica de encapsulaci\u00f3n de\u00a0fotomoldes\u00a0que hab\u00edan desarrollado previamente. Luego, indujeron la liberaci\u00f3n de diferentes concentraciones de IL-6 en las muestras\u00a0y analizaron cada una con\u00a0su biosensor. El biosensor, que se basa en una nanoestructura\u00a0plasm\u00f3nica\u00a0–\u00a0una part\u00edcula cuya densidad de electrones puede acoplarse con radiaci\u00f3n electromagn\u00e9tica de longitudes de onda mucho m\u00e1s grandes que la propia part\u00edcula\u00a0–\u00a0mostr\u00f3 una mayor sensibilidad al medir variaciones en las concentraciones de IL-6, incluso cuando eran extremadamente bajas.<\/span>\u00a0<\/span><\/p>\n

De hecho, esta t\u00e9cnica super\u00f3 a otras plataformas de biosensores\u00a0plasm\u00f3nicas\u00a0y\u00a0nanopl\u00e1smicas\u00a0en al menos un orden de magnitud en la detecci\u00f3n de IL-6 en el tejido muscular. Su sensibilidad\u00a0fue\u00a0similar a la de las plataformas de\u00a0biodetecci\u00f3n\u00a0electroqu\u00edmicas, pero ofrece la ventaja adicional de ser directa y sin\u00a0necesidad de usar marcadores. Adem\u00e1s, gracias al uso de\u00a0nanocristales\u00a01D fabricados a escala industrial presentes en Blu-ray, podr\u00eda convertirse en un sensor multicanal altamente reproducible.<\/span>\u00a0<\/span><\/p>\n

Una herramienta prometedora para la evaluaci\u00f3n de medicamentos<\/span><\/span>\u00a0<\/span><\/strong><\/h3>\n

Los autores identifican nuevas oportunidades para afinar su t\u00e9cnica, incluido el uso de otros materiales\u00a0plasm\u00f3nicos\u00a0como el grafeno o el oro nanoporoso, para extender su aplicaci\u00f3n a una gama m\u00e1s amplia de biomarcadores.<\/span>\u00a0<\/span><\/p>\n

Su\u00a0nuevo\u00a0enfoque ofrece una cuantificaci\u00f3n directa, sin\u00a0marcadores\u00a0y en tiempo real de biomarcadores que minimiza la complejidad de\u00a0utilizaci\u00f3n. Podr\u00eda usarse para medir biomarcadores en tejidos u\u00a0organoides\u00a0producidos por\u00a0bioingenier\u00eda\u00a03D en\u00a0las fases iniciales del\u00a0testeo de nuevos f\u00e1rmacos candidatos para inn\u00fameras enfermedades.\u00a0Los estudios futuros se centrar\u00e1n en la\u00a0biodetecci\u00f3n\u00a0multiplexada y en tiempo real para desarrollar plataformas de seguimiento de cultivos celulares.<\/span>\u00a0<\/span><\/p>\n

Nuestra t\u00e9cnica super\u00f3 a otras plataformas de biosensores de este tipo en al menos un orden de magnitud en la detecci\u00f3n de IL-6 en tejido muscular.<\/span><\/span>\u00a0<\/span><\/strong><\/p>\n

Javier Ramon, profesor de investigaci\u00f3n ICREA\u00a0<\/span>en\u00a0<\/span>el IBEC<\/span><\/span>\u00a0<\/span><\/strong><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

Art\u00edculo de referencia:\u00a0<\/strong><\/p>\n

Gerardo A Lopez-Mu\u00f1oz,\u202fJuan M Fern\u00e1ndez-Costa\u202f<\/span>,\u202fMaria Alejandra Ortega,\u202fJordina Balaguer-Trias,\u202fEduard Martin-Lasierra\u202fand\u202fJavier Ram\u00f3n-Azc\u00f3n.\u00a0<\/span>Plasmonic nanocrystals on polycarbonate substrates for direct and label-free\u00a0biodetection\u00a0of Interleukin-6 in bioengineered 3D skeletal muscles<\/span><\/a>.\u00a0<\/span>Nanophotonics<\/span><\/a>, 2021.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

En una publicaci\u00f3n reciente en la revista Nanophotonics, investigadores del IBEC presentan un nuevo biosensor para la detecci\u00f3n directa y sensible de la prote\u00edna interleucina-6 en el m\u00fasculo, un indicador de inflamaci\u00f3n y de potencial enfermedad, demostrando el alto rendimiento del dispositivo en m\u00fasculos esquel\u00e9ticos obtenidos por bioingenier\u00eda 3D. Este nuevo enfoque puede resultar en una herramienta prometedora para medir la eficacia de f\u00e1rmacos frente a enfermedades en las que hay inflamaci\u00f3n, como la distrofia muscular. <\/h3>\n","protected":false},"author":4,"featured_media":88154,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1130],"post_formats":[],"class_list":["post-88644","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-javier-ramon-es"],"yoast_head":"\nNuevo biosensor con alta sensibilidad detecta marcador inflamatorio en m\u00fasculo - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/nuevo-biosensor-con-alta-sensibilidad-detecta-marcador-inflamatorio-en-musculo\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuevo biosensor con alta sensibilidad detecta marcador inflamatorio en m\u00fasculo - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En una publicaci\u00f3n reciente en la revista Nanophotonics, investigadores del IBEC presentan un nuevo biosensor para la detecci\u00f3n directa y sensible de la prote\u00edna interleucina-6 en el m\u00fasculo, un indicador de inflamaci\u00f3n y de potencial enfermedad, demostrando el alto rendimiento del dispositivo en m\u00fasculos esquel\u00e9ticos obtenidos por bioingenier\u00eda 3D. 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