{"id":88650,"date":"2021-11-12T11:00:57","date_gmt":"2021-11-12T10:00:57","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=88650"},"modified":"2021-11-16T12:25:42","modified_gmt":"2021-11-16T11:25:42","slug":"investigadores-descubren-como-las-membranas-celulares-cambian-la-curvatura-en-funcion-de-las-proteinas-bar","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/investigadores-descubren-como-las-membranas-celulares-cambian-la-curvatura-en-funcion-de-las-proteinas-bar\/","title":{"rendered":"Investigadores descubren c\u00f3mo las membranas celulares cambian la curvatura en funci\u00f3n de las prote\u00ednas BAR"},"content":{"rendered":"
\"\"
Simulaciones de un tubo de membrana (600 nm de di\u00e1metro) reformado din\u00e1micamente por una prote\u00edna BAR.<\/span><\/span>\u00a0<\/span><\/figcaption><\/figure>\n

El cuerpo humano es un mosaico complejo formado por un gran n\u00famero de c\u00e9lulas con diferentes propiedades, pero todas comparten una caracter\u00edstica com\u00fan: poseen una envoltura externa (tambi\u00e9n llamada membrana), que se curva a escala microm\u00e9trica y nanom\u00e9trica.<\/span>\u00a0<\/span><\/p>\n

Durante funciones celulares esenciales como la migraci\u00f3n,\u00a0la\u00a0endo\/exocitosis, o cuando se deforman por fuerzas externas, las membranas celulares cambian constantemente\u00a0de forma. Aqu\u00ed, las prote\u00ednas BAR juegan un papel fundamental. Sin embargo,\u00a0no se conoc\u00edan bien los detalles de\u00a0la din\u00e1mica y la\u00a0mecanoqu\u00edmica\u00a0del proceso hasta\u00a0el momento.<\/span>\u00a0<\/span><\/p>\n

Ahora, un grupo de investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y de la Universidad Polit\u00e9cnica de Catalu\u00f1a (UPC) publican nuevos resultados en la\u00a0<\/span>Revista\u00a0Nature\u00a0Communications<\/span><\/i><\/a>, que sientan las bases para comprender varios procesos de deformaci\u00f3n de membranas, que ocurren tanto\u00a0en escenarios fisiol\u00f3gicos normales de la c\u00e9lula, como en situaciones de enfermedad.\u00a0Espec\u00edficamente, los investigadores describen eventos novedosos de remodelaci\u00f3n de estructuras de membrana de baja curvatura por prote\u00ednas BAR, que anteriormente no se consideraban. Los investigadores tambi\u00e9n muestran c\u00f3mo la deformaci\u00f3n mec\u00e1nica de la membrana desencadena una respuesta bioqu\u00edmica mediada por prote\u00ednas BAR.<\/span>\u00a0<\/span><\/p>\n

La clave para comprender las membranas celulares y su curvatura<\/span><\/span>\u00a0<\/span><\/strong><\/h3>\n

Experimentalmente, los investigadores desarrollaron un sistema\u00a0<\/span>in vitro<\/span><\/i>\u00a0para deformar mec\u00e1nicamente membranas artificiales, exponerlas a prote\u00ednas BAR purificadas y observar la din\u00e1mica resultante\u00a0mediante\u00a0microscop\u00eda\u00a0confocal. Adem\u00e1s, los investigadores desarrollaron modelos te\u00f3ricos para comprender el proceso,\u00a0analizando\u00a0la\u00a0din\u00e1mica y\u00a0mecanoqu\u00edmica. Combinando enfoques experimentales y te\u00f3ricos, los investigadores tambi\u00e9n observaron que las deformaciones de la membrana celular dependen de la forma inicial de la membrana.<\/span>\u00a0<\/span><\/p>\n

Anabel-Lise le Roux (IBEC) y Caterina\u00a0Tozzi\u00a0(UPC),\u00a0co-primeras\u00a0autoras del estudio, explican la importancia de contar con enfoques tanto experimentales como te\u00f3ricos para comprender procesos de deformaci\u00f3n tan complejos:<\/span>\u00a0<\/span><\/p>\n

La interacci\u00f3n realmente estrecha entre los experimentos y\u00a0<\/span>la modelizaci\u00f3n<\/span>\u00a0fue esencial para comprender en profundidad un proceso\u00a0<\/span>mecanoqu\u00edmico<\/span>\u00a0muy complejo<\/span>.<\/span><\/strong><\/p>\n

Anabel-Lise<\/span> Le Roux y<\/span>\u00a0Caterina\u00a0<\/span>Tozzi<\/span>.<\/span><\/span>\u00a0<\/span><\/strong><\/p>\n<\/blockquote>\n

El trabajo publicado<\/span>,<\/span>\u00a0en\u00a0<\/span>Nature<\/span>\u00a0Communications<\/span>,<\/span>\u00a0<\/span>ha sido liderado por los investigadores senior\u00a0<\/span>Marino Arroyo (UPC) y Pere Roca-<\/span>Cusachs<\/span>\u00a0(IBEC \/ UB).<\/span><\/span>\u00a0<\/span><\/p>\n

Art\u00edculo de referencia: <\/strong>Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani , Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo, Pere Roca-Cusachs. Dynamic Mechanochemical feedback between curved membranes and BAR protein self-organization.<\/a> Nat Commun<\/i>\u00a012,\u00a0<\/b>6550 (2021).<\/p>\n","protected":false},"excerpt":{"rendered":"

Un equipo de investigadores del IBEC y de la UPC, dirigido por Pere Roca-Cusachs y Marino Arroyo, estudia c\u00f3mo las prote\u00ednas BAR, una familia de mol\u00e9culas que se unen a las membranas celulares curvas, son capaces de remodelarlas. Los cient\u00edficos publican en la revista Nature Communications, a trav\u00e9s de experimentos y modelos, la din\u00e1mica de estos procesos de remodelaci\u00f3n de membranas que ocurren tanto en c\u00e9lulas normales como en escenarios de enfermedades. <\/h3>\n","protected":false},"author":4,"featured_media":88584,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1135],"post_formats":[],"class_list":["post-88650","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-pere-roca-cusachs-es"],"yoast_head":"\nInvestigadores descubren c\u00f3mo las membranas celulares cambian la curvatura en funci\u00f3n de las prote\u00ednas BAR - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-descubren-como-las-membranas-celulares-cambian-la-curvatura-en-funcion-de-las-proteinas-bar\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores descubren c\u00f3mo las membranas celulares cambian la curvatura en funci\u00f3n de las prote\u00ednas BAR - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un equipo de investigadores del IBEC y de la UPC, dirigido por Pere Roca-Cusachs y Marino Arroyo, estudia c\u00f3mo las prote\u00ednas BAR, una familia de mol\u00e9culas que se unen a las membranas celulares curvas, son capaces de remodelarlas. 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