{"id":89143,"date":"2021-11-25T09:20:49","date_gmt":"2021-11-25T08:20:49","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=89143"},"modified":"2021-12-03T12:28:26","modified_gmt":"2021-12-03T11:28:26","slug":"desvelando-el-punto-dulce-de-las-celulas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/desvelando-el-punto-dulce-de-las-celulas\/","title":{"rendered":"Desvelando el punto dulce de las c\u00e9lulas"},"content":{"rendered":"<p><img decoding=\"async\" class=\"wp-image-88783 alignleft lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Nat.-Chem.-Biol.-2021-1712.jpg\" alt=\"\" width=\"346\" height=\"459\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Nat.-Chem.-Biol.-2021-1712.jpg 440w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Nat.-Chem.-Biol.-2021-1712-226x300.jpg 226w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/11\/Nat.-Chem.-Biol.-2021-1712-113x150.jpg 113w\" data-sizes=\"(max-width: 346px) 100vw, 346px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 346px; --smush-placeholder-aspect-ratio: 346\/459;\" \/><\/p>\n<p><span data-contrast=\"auto\">Los az\u00facares interact\u00faan con la superficie celular\u00a0uni\u00e9ndose a\u00a0prote\u00ednas llamadas lectinas.\u00a0Estas\u00a0interacciones\u00a0juegan\u00a0un\u00a0papel\u00a0fundamental\u00a0en\u00a0muchos\u00a0de los\u00a0procesos\u00a0biol\u00f3gicos\u00a0de la\u00a0c\u00e9lula.\u00a0Una\u00a0funci\u00f3n\u00a0importante es la\u00a0modulaci\u00f3n\u00a0de la\u00a0respuesta\u00a0inmune\u00a0frente\u00a0a\u00a0una\u00a0amenaza\u00a0externa.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">El\u00a0estudiante de\u00a0doctorado Roger Riera, del<\/span><a href=\"https:\/\/ibecbarcelona.eu\/nanoscopy\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">\u00a0grupo de Nanoscopia para Nanomedicina<\/span><\/a><span data-contrast=\"auto\"> del IBEC y la TUE, dirigido por Lorenzo Albertazzi, investiga los receptores de la superficie celular y su interacci\u00f3n con mol\u00e9culas, utilizando t\u00e9cnicas novedosas de microscop\u00eda. La idea de visualizar las interacciones az\u00facar-lectina empez\u00f3 a partir de una consolidada colaboraci\u00f3n con investigadores de la Universidad de Leiden. \u201cHemos unido dos campos: nuestros colaboradores desarrollan sondas de az\u00facar y nosotros aportamos la experiencia en microscop\u00eda\u201d, dice Riera.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h3><strong><span class=\"TextRun SCXW235602062 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW235602062 BCX8\">CAPTAR LA IMAGEN DE<\/span><span class=\"NormalTextRun SCXW235602062 BCX8\">\u00a0LOS AZ\u00daCARES UNO A UNO<\/span><span class=\"NormalTextRun SCXW235602062 BCX8\">\u00a0<\/span><\/span><span class=\"EOP SCXW235602062 BCX8\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/strong><\/h3>\n<p><span class=\"TextRun SCXW222340347 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00abNuestra idea era utilizar los mismos az\u00facares que interact\u00faan con las c\u00e9lulas como s<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">ondas<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0de microscop\u00eda\u00bb, explica Lorenzo Albertazzi, profesor asociado y l\u00edder del grupo de\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">Nanoscopia<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0para Nanomedicina. \u00abNo\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">necesit\u00e1bamos<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">cambiar<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0los\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">componentes<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">b\u00e1sicos<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00ab. La\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">interacci\u00f3n<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0de los\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">az\u00facares<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0con las\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">c\u00e9lulas<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0es\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">d\u00e9bil<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">, lo que\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">dificulta<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">su<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">estudio<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0con\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">t\u00e9cnicas<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0de\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">fluorescencia<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">convencionales<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">. \u00abDe\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">hecho<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">,\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">necesitamos<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">interacciones<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">d\u00e9biles<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0para\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">nuestro<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">m\u00e9todo<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0de\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">microscop\u00eda<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00ab,\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">subraya<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">Riera<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">. \u00abEs\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">una<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">combinaci\u00f3n<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0perfecta. Las im\u00e1genes se basan en interacciones reversibles: l<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">as sondas<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0de az\u00facar marcad<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">a<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">s con fluorescencia se unen durante un tiempo muy corto a las lectinas de la c\u00e9lula y\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">luego\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">se separan. Este\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">proceso se repite a lo largo del tiempo, lo que permite la detecci\u00f3n de interacciones individuales entre el az\u00facar y la lectina\u00bb.\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">Este estudio revel\u00f3\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">propiedades interesantes. \u00ab<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">Pudimos<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0ver que\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">diferentes<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">estructuras<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0de\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">az\u00facar<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">presentaban<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">cin\u00e9ticas<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0de\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">uni\u00f3n<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">distintas<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">,\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">permiti\u00e9ndonos<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">entender<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">mejor<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">su<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">relaci\u00f3n<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">estructura-actividad<\/span><span class=\"NormalTextRun SCXW222340347 BCX8\">\u00ab.\u00a0<\/span><\/span><span class=\"EOP SCXW222340347 BCX8\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<blockquote><p><strong><span class=\"NormalTextRun  BCX8 SCXW252718872\">Nuestros m\u00e9todos podr\u00edan utilizarse para entender mejor c\u00f3mo las c\u00e9lulas inmunes reconocen ciertos az\u00facares\u00a0<\/span><span class=\"NormalTextRun  BCX8 SCXW252718872\">y no\u00a0<\/span><span class=\"NormalTextRun  BCX8 SCXW252718872\">otros<\/span>.<\/strong><\/p>\n<p style=\"text-align: right;\"><strong>Lorenzo\u00a0Albertazzi\u00a0<\/strong><\/p>\n<\/blockquote>\n<h3><strong><span class=\"TextRun SCXW232161428 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW232161428 BCX8\">EL C\u00d3DIGO SOS DEL AZ\u00daCAR<\/span><\/span><span class=\"EOP SCXW232161428 BCX8\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/strong><\/h3>\n<p><span data-contrast=\"auto\">En\u00a0algunos\u00a0casos, los\u00a0az\u00facares\u00a0pueden\u00a0ser\u00a0una\u00a0se\u00f1al\u00a0de\u00a0peligro\u00a0y\u00a0provocar\u00a0una\u00a0activaci\u00f3n\u00a0inmunitaria.\u00a0Esta\u00a0indicaci\u00f3n\u00a0ocurre\u00a0cuando\u00a0el\u00a0cuerpo\u00a0reconoce\u00a0los\u00a0az\u00facares\u00a0de la\u00a0membrana\u00a0de\u00a0un\u00a0pat\u00f3geno. \u00abLas c\u00e9lulas inmunes reconocen la diferencia entre nuestros\u00a0proprios\u00a0az\u00facares y los de un pat\u00f3geno, al reconocer los patrones de az\u00facar\u00bb, aclara Riera. \u00abEstos patrones dependen de la\u00a0estructura\u00a0del\u00a0az\u00facar\u00bb.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u00bfSon los\u00a0az\u00facares\u00a0candidatos\u00a0para\u00a0desarrollar\u00a0vacunas\u00a0m\u00e1s\u00a0potentes? \u00abPodemos utilizar az\u00facares para enga\u00f1ar al sistema inmunol\u00f3gico para que piense que es una se\u00f1al de peligro y estimular una respuesta inmunitaria, similar a la de las vacunas\u00bb, explica. Sin embargo, hay un\u00a0\u201cpunto\u00a0dulce\u201d\u00a0a tener en cuenta\u00a0para hacerlo correctamente. \u00abSi\u00a0utilizas\u00a0los\u00a0az\u00facares\u00a0incorrectos, la\u00a0respuesta\u00a0inmune\u00a0ser\u00e1\u00a0muy\u00a0diferente\u00bb,\u00a0especifica\u00a0Albertazzi.\u00a0Pero\u00a0se\u00a0necesita\u00a0m\u00e1s\u00a0investigaci\u00f3n.\u00a0<\/span><span data-contrast=\"auto\">\u00abNuestros m\u00e9todos podr\u00edan utilizarse para entender mejor c\u00f3mo las c\u00e9lulas inmunes reconocen ciertos az\u00facares\u00a0y no\u00a0otros\u00bb,\u00a0concluye\u00a0Albertazzi.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<hr \/>\n<hr \/>\n<p><b><span data-contrast=\"auto\">Art\u00edculo de referencia:<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><span data-contrast=\"none\">Riera, R.,\u00a0Hogervorst, T.P.,\u00a0Doelman, W.\u202f<\/span><i><span data-contrast=\"none\">et al.<\/span><\/i><span data-contrast=\"none\">\u202f<\/span><a href=\"https:\/\/www.nature.com\/articles\/s41589-021-00896-2\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Single-molecule imaging of\u00a0glycan\u2013lectin\u00a0interactions\u00a0on\u00a0cells\u00a0with\u00a0Glyco-PAINT<\/span><\/a><span data-contrast=\"none\">.\u202f<\/span><i><span data-contrast=\"none\">Nat\u00a0Chem\u00a0Biol<\/span><\/i><span data-contrast=\"none\">\u202f<\/span><b><span data-contrast=\"none\">17,\u202f<\/span><\/b><span data-contrast=\"none\">1281\u20131288 (2021).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<h3>En un reciente art\u00edculo en la revista Nature Chemical Biology, un equipo de investigadores del ICMS\/TUE y del IBEC, junto con investigadores de la Universidad de Leiden, descifran las interacciones de mol\u00e9culas individuales de az\u00facar con c\u00e9lulas, a trav\u00e9s de la microscop\u00eda de superresoluci\u00f3n. El art\u00edculo apareci\u00f3 en la portada de la edici\u00f3n de noviembre de la revista.<\/h3>\n","protected":false},"author":4,"featured_media":88792,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1056],"post_formats":[],"class_list":["post-89143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-lorenzo-albertazzi-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Desvelando el punto dulce de las c\u00e9lulas - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/desvelando-el-punto-dulce-de-las-celulas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desvelando el punto dulce de las c\u00e9lulas - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En un reciente art\u00edculo en la revista Nature Chemical Biology, un equipo de investigadores del ICMS\/TUE y del IBEC, junto con investigadores de la Universidad de Leiden, descifran las interacciones de mol\u00e9culas individuales de az\u00facar con c\u00e9lulas, a trav\u00e9s de la microscop\u00eda de superresoluci\u00f3n. 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