{"id":93287,"date":"2022-02-24T09:41:00","date_gmt":"2022-02-24T08:41:00","guid":{"rendered":"https:\/\/testweb.ibecbarcelona.eu\/?p=93287"},"modified":"2022-04-04T09:55:17","modified_gmt":"2022-04-04T07:55:17","slug":"la-falta-de-proteina-prionica-celular-podria-provocar-sintomas-de-epilepsia-y-deficit-de-aprendizaje","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/la-falta-de-proteina-prionica-celular-podria-provocar-sintomas-de-epilepsia-y-deficit-de-aprendizaje\/","title":{"rendered":"La falta de prote\u00edna pri\u00f3nica celular podr\u00eda provocar s\u00edntomas de epilepsia y d\u00e9ficit de aprendizaje"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Investigadors de l&#8217;IBEC, en col\u00b7laboraci\u00f3 amb hospitals i socis internacionals, han oInvestigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC), en colaboraci\u00f3n con hospitales y socios internacionales, observan que la falta de la prote\u00edna pri\u00f3nica celular provoca d\u00e9ficits de comportamiento, deficiencias en el aprendizaje y un aumento de excitabilidad del cerebro, similar a la epilepsia, en ratones.<\/h4>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\" style=\"grid-template-columns:45% auto\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/02\/medical-ct-mri-pet-scan-film-computer-monitor-technologically-advanced-functional-medical-office.jpg\" alt=\"\" class=\"wp-image-90612 size-full lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/333;\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p style=\"font-size:17px\">La prote\u00edna pri\u00f3nica celular (PrPC), una mol\u00e9cula situada en la superficie de las c\u00e9lulas neuronales, es conocida por encontrarse en niveles anormales en pacientes que padecen enfermedades neurodegenerativas como el Alzheimer y el Parkinson. Sin embargo, un mejor conocimiento sobre la participaci\u00f3n de PrPC en estas enfermedades, contrasta con los datos sobre su rol natural y promotor de la salud. Mientras algunos estudios\u00a0 describen a esta prote\u00edna como protectora para el cerebro, en otros estudios la misma PrPC ha sido asociada a una mayor susceptibilidad a la neurotoxicidad.<\/p>\n<\/div><\/div>\n\n\n\n<p>Dichas inconsistencias se deben principalmente a la ausencia de modelos de ratones adecuados y bien caracterizados. Para arrojar algo m\u00e1s de luz a la funci\u00f3n real de PrPC en fisiolog\u00eda neuronal, investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) dirigidos por Jos\u00e9 Antonio del R\u00edo, catedr\u00e1tico de la Universidad de Barcelona (UB) y l\u00edder del grupo del IBEC han trabajado intensamente los \u00faltimos cinco a\u00f1os estudiando ratones transg\u00e9nico sin PrPC, e informan ahora sobre ello en la revista BCM Biology, con resultados sorprendentes.&nbsp;<\/p>\n\n\n\n<p>Cient\u00edficos del grupo de <a href=\"https:\/\/ibecbarcelona.eu\/neurobiotechnology\" target=\"_blank\" rel=\"noreferrer noopener\">Neurobiotecnolog\u00eda Molecular y Celular<\/a> del IBEC, en colaboraci\u00f3n con el Hospital Universitario de Z\u00farich, la Universidad de Barcelona y la Universidad Pablo de Olavide de Sevilla (Espa\u00f1a), han descubierto que la ausencia de PrPC perjudica las funciones cognitivas como el aprendizaje asociativo y la memoria, y produce un comportamiento similar a la ansiedad. Los expertos tambi\u00e9n han encontrado que la deficiencia de PrPC comporta una mayor susceptibilidad a las convulsiones epil\u00e9pticas en estos ratones.\u00a0<\/p>\n\n\n\n<blockquote class=\"wp-block-quote has-text-align-right is-style-plain is-layout-flow wp-block-quote-is-layout-flow\" style=\"font-size:15px\"><p>Los investigadores han trabajado durante d\u00e9cadas con ratones modificados con\u202fPrPC, sin conocer el impacto en su salud, debido a algunos inconvenientes t\u00e9cnicos que presentaban los modelos desarrollados anteriormente. Utilizando unos ratones eliminadores de PrPC generados por TALEN, ahora hemos descubierto que los animales que no expresan la prote\u00edna presentan s\u00edntomas similares a la epilepsia y una deficiencia en el aprendizaje y en la memoria que refuerza el papel de la prote\u00edna en estos procesos, y que pueden ayudar a entender los efectos de su disminuci\u00f3n observada en algunas enfermedades neurodegenerativas en las personas.\u00a0<\/p><p><\/p><cite>Jos\u00e9 Antonio del R\u00edo, l\u00edder de grupo en IBEC\u00a0<\/cite><\/blockquote>\n\n\n\n<p>En su estudio, los investigadores realizaron un conjunto completo de pruebas de condicionamiento conductual y operante para evaluar la memoria y las capacidades de aprendizaje de los ratones, en paralelo con la secuenciaci\u00f3n de RNA, el an\u00e1lisis de la red de neuronas <em>in vitro<\/em> y datos electrofisiol\u00f3gicos <em>in vivo<\/em>. Los resultados mostraron una clara disminuci\u00f3n de la motilidad, deficiencias en el aprendizaje del condicionamiento operante y un comportamiento relacionado con la ansiedad en los animales sin PrPC.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Los resultados demuestran que la prote\u00edna PrPC favorece la formaci\u00f3n de redes neuronales y la conectividad, media en la funci\u00f3n sin\u00e1ptica, y protege tambi\u00e9n de la excitotoxicidad. La supresi\u00f3n de PrPC, concluyen los investigadores, puede ser la base de un cerebro susceptible a la epilepsia, ya que los animales estudiados no pueden realizar tareas cognitivas muy exigentes, como el aprendizaje asociativo y presentan comportamientos similares a la ansiedad.&nbsp;<\/p>\n\n\n\n<p>Este estudio, realizado en los \u00faltimos a\u00f1os, ha contado con el apoyo de La Caixa Research, del Proyecto PRPSEM del Ministerio de Ciencia e Innovaci\u00f3n, del CIBERNED, del Programa CERCA y de la Comisi\u00f3n de Universidades e Investigaci\u00f3n del Departamento de Innovaci\u00f3n, Universidades y Empresa de la Generalitat de Catalu\u00f1a.&nbsp;<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Art\u00edculo de referencia: <\/strong>Matamoros-Angles et al. <a href=\"https:\/\/bmcbiol.biomedcentral.com\/articles\/10.1186\/s12915-021-01203-0\" target=\"_blank\" rel=\"noreferrer noopener\">Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability<\/a>. BMC Biology 2022.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<h3>Investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC), en colaboraci\u00f3n con hospitales y socios internacionales, observan que la falta de la prote\u00edna pri\u00f3nica celular provoca d\u00e9ficits de comportamiento, deficiencias en el aprendizaje y un aumento de excitabilidad del cerebro, similar a la epilepsia, en ratones.  <\/h3>\n","protected":false},"author":4,"featured_media":93284,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1133,1583],"post_formats":[],"class_list":["post-93287","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-jose-antonio-del-rio-es","tag-molecular-and-cellular-neurobiotechnology-group-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La falta de prote\u00edna pri\u00f3nica celular podr\u00eda provocar s\u00edntomas de epilepsia y d\u00e9ficit de aprendizaje - 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