{"id":93320,"date":"2022-03-17T12:13:00","date_gmt":"2022-03-17T11:13:00","guid":{"rendered":"https:\/\/testweb.ibecbarcelona.eu\/?p=93320"},"modified":"2022-04-04T12:31:21","modified_gmt":"2022-04-04T10:31:21","slug":"innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\/","title":{"rendered":"Innovadoras esferas hechas con bioingenier\u00eda podr\u00edan ayudar a tratar la diabetes"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Investigadores del IBEC, en colaboraci\u00f3n con el IDIBAPS en Barcelona, \u200b\u200bhan desarrollado peque\u00f1as esferas capaces de responder a variaciones en los niveles de glucosa y producir insulina in vitro. Estos esferoides biomim\u00e9ticos y no t\u00f3xicos contienen c\u00e9lulas \u03b2 pancre\u00e1ticas y se prepararon utilizando la bioimpresi\u00f3n 3D. Este enfoque podr\u00eda ayudar en el futuro a mejorar los resultados cl\u00ednicos de las estrategias de trasplante de c\u00e9lulas \u03b2 para el tratamiento de la diabetes, as\u00ed como para las plataformas in vitro de desarrollo de f\u00e1rmacos.<\/h4>\n\n\n\n<div class=\"wp-block-image size-full wp-image-90919 is-style-default\"><figure class=\"aligncenter\"><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/03\/senior-woman-makes-blood-glucose-test.jpg\" alt=\"\" class=\"wp-image-90919 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><figcaption>Mujer se hace un test de glucosa en sangre<\/figcaption><\/figure><\/div>\n\n\n\n<p>La Diabetes Mellitus es una enfermedad metab\u00f3lica caracterizada por un fallo en la producci\u00f3n de insulina, la hormona responsable por la regulaci\u00f3n de los niveles de glucosa en la sangre, por las c\u00e9lulas \u03b2 del p\u00e1ncreas. En 2019, seg\u00fan la Organizaci\u00f3n Mundial de la Salud, la diabetes provoc\u00f3 la muerte de 1,5 millones de personas en todo el mundo, y en la actualidad hay m\u00e1s de 420 millones de personas afectadas por esta enfermedad.&nbsp;<\/p>\n\n\n\n<p>En la diabetes tipo 1 (T1DM), una enfermedad autoinmune, un tipo de c\u00e9lulas llamadas c\u00e9lulas \u03b2 y que se encuentran en los islotes pancre\u00e1ticos, son destruidas por el sistema inmunitario, evitando la producci\u00f3n de insulina. El tratamiento m\u00e1s extendido en este caso es la inyecci\u00f3n regular de insulina por parte de los pacientes, durante toda su vida, para controlar los altos niveles de glucosa en sangre. Sin embargo, como esta terapia no simula la secreci\u00f3n de insulina en tiempo real por parte de las c\u00e9lulas \u03b2, termina por causar complicaciones cr\u00f3nicas graves, como enfermedades cardiovasculares y nefropat\u00eda.&nbsp;<\/p>\n\n\n\n<p>Una alternativa terap\u00e9utica prometedora contra la T1DM es el trasplante de islotes pancre\u00e1ticos conteniendo c\u00e9lulas \u03b2 a los pacientes. Sin embargo, esta t\u00e9cnica todav\u00eda no se puede aplicar en la cl\u00ednica debido a complicaciones, como la mala oxigenaci\u00f3n y vascularizaci\u00f3n de las c\u00e9lulas, que limitan mucho su retenci\u00f3n despu\u00e9s del implante.&nbsp;<\/p>\n\n\n\n<p>Para superar estos obst\u00e1culos, investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) liderados por el Profesor de Investigaci\u00f3n ICREA Javier Ram\u00f3n, investigador prinicpal del Grupo de <a href=\"https:\/\/ibecbarcelona.eu\/biosensors\" target=\"_blank\" rel=\"noreferrer noopener\">Biosensores para Bioingenier\u00eda<\/a>, en colaboraci\u00f3n con investigadores del IDIBAPS, han desarrollado una metodolog\u00eda de alto rendimiento aplicando bioimpresi\u00f3n 3D para encapsular c\u00e9lulas \u03b2 dentro de esferoides de col\u00e1geno-\u00e1cido t\u00e1nico. Esta estrategia innovadora puede aumentar el \u00e9xito del trasplante de islotes pancre\u00e1ticos y se ha publicado recientemente en la revista <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/admt.202101696\" target=\"_blank\" rel=\"noreferrer noopener\">Advanced Materials Technologies<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3<strong>Esferoides bioimpresos en 3D conteniendo c\u00e9lulas \u03b2 producen insulina <em>in vitro<\/em><\/strong><\/strong><\/h3>\n\n\n\n<p>Una estrategia para aumentar la retenci\u00f3n de c\u00e9lulas \u03b2 despu\u00e9s del trasplante es usar biomateriales protectores semipermeables para encapsular las c\u00e9lulas. Estos tejidos, obtenidos por bioingenier\u00eda, se conocen como esferoides o microesferas encapsuladas, y confieren propiedades biocompatibles que proporcionan una uni\u00f3n celular m\u00e1s efectiva, reduciendo la p\u00e9rdida de c\u00e9lulas y actuando como una barrera protectora f\u00edsica frente al sistema inmunol\u00f3gico del paciente.<\/p>\n\n\n\n<div class=\"wp-block-image is-style-default\"><figure class=\"alignleft\"><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/03\/imagen-del-paper-1.jpg\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/03\/imagen-del-paper-1.jpg\" alt=\"\" class=\"wp-image-90916 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/a><\/figure><\/div>\n\n\n\n<p>El nuevo enfoque propuesto por los investigadores del IBEC emplea tecnolog\u00eda de bioimpresi\u00f3n 3D para desarrollar esferoides de col\u00e1geno unidos a mol\u00e9culas de \u00e1cido t\u00e1nico, en un intento de imitar el microambiente de la matriz extracelular de las c\u00e9lulas \u03b2 <em>in vivo<\/em>. La uni\u00f3n al \u00e1cido t\u00e1nico evita la degradaci\u00f3n por la colagenasa, mejora la consistencia estructural esf\u00e9rica y permite personalizar el di\u00e1metro de las microesferas con una variabilidad extremadamente baja.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-style-plain is-layout-flow wp-block-quote-is-layout-flow\" style=\"font-size:16px\"><p><strong><strong>Nuestro enfoque de alto rendimiento facilita la fabricaci\u00f3n de un sistema de encapsulaci\u00f3n celular que garantiza una buena supervivencia y funcionalidad de las c\u00e9lulas \u03b2 productoras de insulina en respuesta a la glucosa.<\/strong><\/strong><\/p><p><\/p><cite>Laura Clua-Ferr\u00e9, investigadora del IBEC y primera autora del estudio<\/cite><\/blockquote>\n\n\n\n<p>Para validar la nueva estrategia, los investigadores prepararon microc\u00e1psulas 3D a base de col\u00e1geno-\u00e1cido t\u00e1nico, unidas a c\u00e9lulas de insulinoma de rata. Observaron que los esferoides mantuvieron la viabilidad celular y la actividad metab\u00f3lica hasta durante 30 d\u00edas, reflejando una correcta difusi\u00f3n de ox\u00edgeno y nutrientes. Adem\u00e1s, la estrategia de uni\u00f3n al \u00e1cido t\u00e1nico mejor\u00f3 la retenci\u00f3n de c\u00e9lulas \u03b2 dentro de los esferoides.<\/p>\n\n\n\n<p>Este novedoso procedimiento de bioimpresi\u00f3n 3D permite la fabricaci\u00f3n de una gran cantidad de microesferas capaces de responder a la glucosa mediante la secreci\u00f3n de insulina, y puede ser \u00fatil para estudios funcionales avanzados destinados al trasplante de c\u00e9lulas \u03b2 para el tratamiento de la diabetes. Adem\u00e1s, esta tecnolog\u00eda puede abrir nuevas v\u00edas y aplicarse a la encapsulaci\u00f3n de una amplia gama de c\u00e9lulas trasplantables.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Art\u00edculo de referencia:<\/strong> Laura Clua-Ferr\u00e9, Francesco de Chiara, J\u00falia Rodr\u00edguez-Comas, Jordi Comelles, Elena Martinez, Amelie Luise Godeau, Ainhoa Garc\u00eda-Alam\u00e1n, Rosa Gasa, and Javier Ram\u00f3n-Azc\u00f3n. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/admt.202101696\" target=\"_blank\" rel=\"noreferrer noopener\">Collagen-Tannic Acid Spheroids for \u03b2-Cell Encapsulation Fabricated Using a 3D Bioprinter<\/a>. Adv. Mater. Technol. 2022, 2101696.\u00a0\u00a0<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><em>Martinez is member of Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER).<br><\/em><em>Garc\u00eda-Alam\u00e1n and R. Gasa are members of Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM).<\/em><\/h6>\n","protected":false},"excerpt":{"rendered":"<h3>Investigadores del IBEC, en colaboraci\u00f3n con el IDIBAPS en Barcelona, \u200b\u200bhan desarrollado peque\u00f1as esferas capaces de responder a variaciones en los niveles de glucosa y producir insulina in vitro. Estos esferoides biomim\u00e9ticos y no t\u00f3xicos contienen c\u00e9lulas \u03b2 pancre\u00e1ticas y se prepararon utilizando la bioimpresi\u00f3n 3D. Este enfoque podr\u00eda ayudar en el futuro a mejorar los resultados cl\u00ednicos de las estrategias de trasplante de c\u00e9lulas \u03b2 para el tratamiento de la diabetes, as\u00ed como para las plataformas in vitro de desarrollo de f\u00e1rmacos. <\/h3>\n","protected":false},"author":4,"featured_media":93310,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1130],"post_formats":[],"class_list":["post-93320","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-javier-ramon-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Innovadoras esferas hechas con bioingenier\u00eda podr\u00edan ayudar a tratar la diabetes - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Innovadoras esferas hechas con bioingenier\u00eda podr\u00edan ayudar a tratar la diabetes - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC, en colaboraci\u00f3n con el IDIBAPS en Barcelona, \u200b\u200bhan desarrollado peque\u00f1as esferas capaces de responder a variaciones en los niveles de glucosa y producir insulina in vitro. Estos esferoides biomim\u00e9ticos y no t\u00f3xicos contienen c\u00e9lulas \u03b2 pancre\u00e1ticas y se prepararon utilizando la bioimpresi\u00f3n 3D. Este enfoque podr\u00eda ayudar en el futuro a mejorar los resultados cl\u00ednicos de las estrategias de trasplante de c\u00e9lulas \u03b2 para el tratamiento de la diabetes, as\u00ed como para las plataformas in vitro de desarrollo de f\u00e1rmacos.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2022-03-17T11:13:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-04-04T10:31:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/04\/senior-woman-makes-blood-glucose-test-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"333\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Innovadoras esferas hechas con bioingenier\u00eda podr\u00edan ayudar a tratar la diabetes\",\"datePublished\":\"2022-03-17T11:13:00+00:00\",\"dateModified\":\"2022-04-04T10:31:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\\\/\"},\"wordCount\":894,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/senior-woman-makes-blood-glucose-test-1.jpg\",\"keywords\":[\"Javier Ram\u00f3n\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/innovadoras-esferas-hechas-con-bioingenieria-podrian-ayudar-a-tratar-la-diabetes\\\/\",\"name\":\"Innovadoras esferas hechas con bioingenier\u00eda podr\u00edan ayudar a tratar la diabetes - 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