{"id":103539,"date":"2023-01-12T12:17:07","date_gmt":"2023-01-12T11:17:07","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?post_type=tribe_events&p=103539"},"modified":"2023-01-12T12:17:07","modified_gmt":"2023-01-12T11:17:07","slug":"irb-research-node-ibec-joint-seminar-nunilo-cremades","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/es\/event\/irb-research-node-ibec-joint-seminar-nunilo-cremades\/","title":{"rendered":"IRB Research Node\/IBEC Joint Seminar: Nunilo Cremades"},"content":{"rendered":"

Date<\/strong><\/b>: Thursday 19 January 2023, 9:30h
\nPlace<\/strong><\/b>: Felix Serratosa Hall, PCB<\/p>\n

Speaker<\/strong><\/b>:\u00a0Nunilo Cremades, PhD –\u00a0Associate Professor at Dept. Biochemistry and Molecular and Cellular Biology and Group Leader at Institute for Biocomputation and Physics of Complex Systems (BIFI),\u00a0University of Zaragoza, Spain<\/p>\n

Title<\/strong><\/b>:\u00a0\u00a0Liquid-liquid phase separation and co-aggregation of neurodegenerative disease-related alpha-synuclein and Tau proteins<\/p>\n

Host<\/strong><\/b>: Xavier Salvatella (IRB) & Benedetta Bolognesi (IBEC)<\/p>\n

Abstract:<\/strong><\/b><\/p>\n

Spatial segregation in the cell can be achieved through the formation of protein-rich liquid-like dense bodies, termed biomolecular condensates or liquid droplets, through a process known as liquid-liquid phase separation (LLPS). Emerging evidence supports the hypothesis that aberrant protein-driven LLPS and the transition of the liquid droplets to solid-like structures might be a relevant cellular pathway leading to the formation of amyloid, toxic aggregates that are often a hallmark of relevant neurodegenerative diseases. A number of experimental studies have highlighted the flexible, typically disordered and \u2018multivalent\u2019 nature of the constituent proteins in these liquid-like condensates, although less is known about the particular molecular determinants governing the growth and maturation of these condensates into more solid-like states. While the LLPS process of Tau, the protein that is generally associated with Alzheimer\u00b4s disease, has been recently clarified, that of alpha-synuclein (\u03b1S), the protein linked to Parkinson\u00b4s disease, remains obscure. In this talk, I will show our recent findings that demonstrate that \u03b1S actively phase-separates into liquid condensates by electrostatic complex coacervation with positively charged polypeptides such as Tau. By combining a set of advanced biophysical techniques, we have been able to characterize \u03b1S\/Tau LLPS and identified key factors leading to the co-aggregation of both proteins inside the coacervates. The mechanism of co-aggregation between \u03b1S and Tau that we have identified could be the basis for the in vivo formation of \u03b1S\/Tau hetero-aggregates observed in the brains of patients suffering from synucleinopathies.<\/p>\n","protected":false},"excerpt":{"rendered":"

Date: Thursday 19 January 2023, 9:30h Place: Felix Serratosa Hall, PCB Speaker:\u00a0Nunilo Cremades, PhD –\u00a0Associate Professor at Dept. 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