{"id":108633,"date":"2023-06-19T09:18:22","date_gmt":"2023-06-19T07:18:22","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?post_type=tribe_events&p=108633"},"modified":"2023-06-19T09:19:46","modified_gmt":"2023-06-19T07:19:46","slug":"phd-thesis-defence-nimesh-ramesh-chahare","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/es\/event\/phd-thesis-defence-nimesh-ramesh-chahare\/","title":{"rendered":"PhD Thesis Defence: Nimesh Ramesh Chahare"},"content":{"rendered":"
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Mechanics of Epithelial tissue subjected to controlled pressure<\/h2>\n<\/div>\n<\/div>\n<\/header>\n
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Author: Nimesh Ramesh Chahare, Integrative Cell and Tissue Dynamics group<\/em><\/div>\n<\/article>\n
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Biography:<\/p>\n

Nimesh Ramesh Chahare earned his bachelor’s degree in Mechanical Engineering from the National Institute of Technology, Nagpur in 2014. He further pursued a master’s degree at the Indian Institute of Science, Bengaluru, completing it in 2016. In 2017, he began his doctoral work in Barcelona, under the guidance of Prof. Marino Arroyo at Universitat Polit\u00e8cnica de Catalunya, and Prof. Xavier Trepat at the Institute of Bioengineering of Catalonia. Currently, he is a PhD candidate in applied mathematics, specializing in the study of the mechanics of epithelial tissue under controlled pressure.<\/p>\n

Abstract:<\/p>\n

Epithelial sheets form specialized 3D structures suited to their physiological roles, such as branched alveoli in the lungs, tubes in the kidney, and villi in the intestine. To generate and maintain these structures, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses, viscoelasticity, and luminal pressure remains poorly understood. To address this question, we developed a microfluidic chip and a computational framework to engineer 3D epithelial tissues with controlled shape and pressure. In the setup, an epithelial monolayer is grown on a porous surface with circular low adhesion zones. On applying hydrostatic pressure, the monolayer delaminates into a spherical cap from the circular zone. This simple shape allows us to calculate epithelial tension using Laplace’s law. Through this approach, we subject the monolayer to a range of lumen pressures at different rates and hence probe the relation between strain and tension in different regimes while computationally tracking actin dynamics and their mechanical effect at the tissue scale. Slow pressure changes relative to the actin dynamics allow the tissue to accommodate large strain variations. However, under sudden pressure reductions, the tissue develops buckling patterns and folds with different degrees of symmetry-breaking to store excess tissue area. These insights allow us to pattern epithelial folds through rationally directed buckling. Our study establishes a new approach for engineering epithelial morphogenetic events.<\/p>\n

 <\/p>\n<\/div>\n

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Reading date: 20\/06\/2023
\nReading time: 15:00<\/p>\n

Reading place: Facultat de Matem\u00e0tiques i Estad\u00edstica-Sala d’Actes FME, Edifici U, Campus Sud
\nThesis director: ARROYO BALAGUER, MARINO and TREPAT GUIXER, XAVIER
\nCommittee:
\nPRESIDENT: TRIVEDI, VIKAS
\nSECRETARI: MU\u00d1OZ ROMERO, JOSE JAVIER
\nVOCAL: SUZANNE, MAGALI<\/p>\n<\/div>\n

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 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Mechanics of Epithelial tissue subjected to controlled pressure Author: Nimesh Ramesh Chahare, Integrative Cell and Tissue Dynamics group Biography: Nimesh Ramesh Chahare earned his bachelor’s degree in Mechanical Engineering from … Read more<\/a><\/p>\n","protected":false},"author":28,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[104],"class_list":["post-108633","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-phd-thesis-defence","cat_phd-thesis-defence"],"yoast_head":"\nPhD Thesis Defence: Nimesh Ramesh Chahare - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/event\/phd-thesis-defence-nimesh-ramesh-chahare\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PhD Thesis Defence: Nimesh Ramesh Chahare - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Mechanics of Epithelial tissue subjected to controlled pressure Author: Nimesh Ramesh Chahare, Integrative Cell and Tissue Dynamics group Biography: Nimesh Ramesh Chahare earned his bachelor’s degree in Mechanical Engineering from ... 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