Workshop held in the framework of the EIC Pathfinder project BIOACTION \u201cBacteria biofilm as bio-factory for tissue regeneration\u201d (Project Number 101098972).<\/p>\n
BIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections, the primary cause of implant infections and failure, into a positive resource. The main goal of BIOACTION is to transform implant-associated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration, exploiting gene sequences loaded on engineered liposomes and phages, bound to hydrogel scaffolds. BIOACTION will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues. It will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and peri-implant infection treatments. The proposed approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone.<\/p>\n
BIOACTION, would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care, health outcomes and to achieve huge socio-economic benefits. The project is strongly interdisciplinary in nature involving expertise biomaterials, synthetic biology, phage and liposome technology, medicine.<\/p>\n
As a results, this innovative approach will bring the research and knowledge far beyond the current state-of-the-art and will lead, through the planned validation, as proof-of-concept of new materials and technique with a broader application in regenerative medicine.<\/p>\n
In this workshop, participants from all the institutions involved in the project will explain their research and activities.<\/strong><\/p>\n <\/p>\n Chairs: Elisabeth Engel, Luigi Ambrosio<\/p>\n 14:30 – Claudia Siverini and Marco Chitt\u00f2 (AO Foundation), \u201cBone infections and treatments\u201d<\/p>\n 14:45 – Dorien Van Hede (Universit\u00e9 de Liege), \u201cDental infections and treatments\u201d<\/p>\n 15:00 – Diego Cotella (Universit\u00e0 degli Studi del Piemonte Orientale), \u00abPhages to control biofilms\u00bb<\/p>\n 15:15 – Dr. Cecilia Bombelli (Consiglio Nazionale delle Ricerche \u2013 Instituto per i Sistemi biologici), \u00abLiposomes in gene therapy\u00bb<\/p>\n 15:30 – Ram\u016bnas Valiokas (Ferentis), \u201cCrosslinked peptide hydrogels for tissue engineering and modeling\u201d<\/p>\n 15:45 – Giovanna Gomez d\u2019Ayala (Consiglio Nazionale delle Ricerche \u2013 Instituto per i Polimeri, Compositi e Biomateriali), \u201cHydrogels for tissue regeneration\u201d<\/p>\n 16:00 – Oscar Casta\u00f1o (IBEC), \u201cAdvanced characterization methodology\u201d<\/p>\n 16:15 – Roberta Marzella (Consiglio Nazionale delle Ricerche – IPCB) and Michela Candotti (IN Society) \u2013 \u201cTips on Management and Dissemination of European Projects\u201d<\/p>\n 16:30 Discussion and conclusions<\/p>\n","protected":false},"excerpt":{"rendered":"