{"id":132912,"date":"2026-03-20T11:11:41","date_gmt":"2026-03-20T10:11:41","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?post_type=tribe_events&p=132912"},"modified":"2026-03-20T11:11:41","modified_gmt":"2026-03-20T10:11:41","slug":"ibec-seminar-dr-pascale-quilichini","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/es\/event\/ibec-seminar-dr-pascale-quilichini\/","title":{"rendered":"Ibec Seminar: Dr Pascale Quilichini"},"content":{"rendered":"

Neuronal infra-slow rhythm in the thalamic nucleus reuniens orchestrate hippocampo-prefrontal information flow during sleep<\/span><\/h3>\n

Dr Pascale Quilichini, Institut de Neurosciences des Syst\u00e8mes, INSERM, Aix-Marseille University<\/em><\/span><\/p>\n

The consolidation of episodic memory during sleep relies on coordinated interactions between the hippocampus (HPC) and the prefrontal cortex (PFC), although these regions lack direct reciprocal connections. The thalamic nucleus reuniens (NR), which is bidirectionally connected to both structures, is therefore a strong candidate for mediating this dialogue. Using simultaneous silicon-probes recordings from the HPC, NR, and PFC in freely sleeping rats, we identified a previously undescribed infra-slow rhythm (ISR) in NR neuronal activity predominantly during non-rapid eye movement (NREM) sleep.<\/div>\n
HPC and PFC neurons were differentially entrained to distinct phases of this rhythm. Consistently, hippocampal sharp-wave ripples (SWRs)\u00a0and\u00a0prefrontal spindles occurred also preferentially during slightly different ISR\u00a0phases. Coupled SWR\u2013spindle events peaked at the onset of the ON phase.<\/div>\n
Furthermore, this coupling was stronger during NREM epochs dominated by ISR compared to those without ISR, and, most importantly, was significantly enhanced during ISR-dominated NREM sleep following spatial learning.<\/div>\n
Together, these findings reveal a novel infra-slow population dynamic in the NR that may temporally coordinate hippocampo\u2013prefrontal interactions during sleep, positioning this nucleus as a key hub in this\u00a0network supporting memory consolidation.<\/div>\n","protected":false},"excerpt":{"rendered":"

Neuronal infra-slow rhythm in the thalamic nucleus reuniens orchestrate hippocampo-prefrontal information flow during sleep Dr Pascale Quilichini, Institut de Neurosciences des Syst\u00e8mes, INSERM, Aix-Marseille University The consolidation of episodic memory … Read more<\/a><\/p>\n","protected":false},"author":54,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[105],"class_list":["post-132912","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-ibec-seminar","cat_ibec-seminar"],"yoast_head":"\nIbec Seminar: Dr Pascale Quilichini - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/event\/ibec-seminar-dr-pascale-quilichini\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ibec Seminar: Dr Pascale Quilichini - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Neuronal infra-slow rhythm in the thalamic nucleus reuniens orchestrate hippocampo-prefrontal information flow during sleep Dr Pascale Quilichini, Institut de Neurosciences des Syst\u00e8mes, INSERM, Aix-Marseille University The consolidation of episodic memory ... 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