{"id":86925,"date":"2021-09-01T17:07:22","date_gmt":"2021-09-01T15:07:22","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/event\/online-ibec-seminar-irene-marco\/"},"modified":"2021-11-29T11:59:30","modified_gmt":"2021-11-29T10:59:30","slug":"online-ibec-seminar-irene-marco","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/es\/event\/online-ibec-seminar-irene-marco\/","title":{"rendered":"Online IBEC Seminar: Irene Marco"},"content":{"rendered":"

Updates on a new lab at IBEC: hyperpolarised magnetic resonance for real-time, in situ monitoring of cell metabolism<\/h2>\n

Irene Marco,<\/em> Molecular Imaging for Precision Medicine group at IBEC<\/em><\/p>\n

There is a clinical need for non-invasive and reliable markers to diagnose, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease.<\/p>\n

Magnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time. \u00a0Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques, including Dynamic Nuclear Polarisation (DNP), which can transiently boost the carbon-13 MR signals by several orders of magnitude, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13<\/sup>C-labelled substrates have provided insights in several metabolic pathways, including glycolysis, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions, tissue ex vivo and animals in vivo. Also, I will talk about the progress we have made at IBEC in the past couple of months and how we plan to implement HP MR to monitor metabolism in organs-in-chips.<\/p>\n

This seminar will be held at Tower I, 11th floor Baobab room, there will be 30 avialable seats, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online, please write to\u00a0ibeccommunications@ibecbarcelona.eu<\/a>.<\/p>\n

More information about Irene Marco\u2019s research here<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Updates on a new lab at IBEC: hyperpolarised magnetic resonance for real-time, in situ monitoring of cell metabolism Irene Marco, Molecular Imaging for Precision Medicine group at IBEC There is … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[353],"class_list":["post-86925","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-ibec-seminar-es","cat_ibec-seminar-es"],"yoast_head":"\nOnline IBEC Seminar: Irene Marco - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/event\/online-ibec-seminar-irene-marco\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Online IBEC Seminar: Irene Marco - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Updates on a new lab at IBEC: hyperpolarised magnetic resonance for real-time, in situ monitoring of cell metabolism Irene Marco, Molecular Imaging for Precision Medicine group at IBEC There is ... 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