{"id":95885,"date":"2015-12-22T08:57:32","date_gmt":"2015-12-22T08:57:32","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?post_type=tribe_events&amp;p=20385"},"modified":"2015-12-22T08:57:32","modified_gmt":"2015-12-22T08:57:32","slug":"ibec-seminar-josef-a-kas-2","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/es\/event\/ibec-seminar-josef-a-kas-2\/","title":{"rendered":"IBEC Seminar:  Josef A. K\u00e4s"},"content":{"rendered":"<hr \/>\n<h2>Why do rigid tumours contain soft cancer cells?<\/h2>\n<address>Prof. Dr. Josef A. K\u00e4s, Principal Investigator &amp; Head of the Soft Matter Physics Division \u00b7 Leipzig University<\/address>\n<p>As early as 400 BCE, the Roman medical encyclopaedist Celsus recognized that solid tumours are stiffer than surrounding tissue. However, cancer cell lines are softer, and softer cells facilitate invasion. This paradox raises several questions: Does softness emerge from adaptation to mechanical and chemical cues in the external microenvironment, or are soft cells already present inside a primary solid tumour? If the latter, how can a more r\u00edgid tissue contain more soft cells? Here we show that in primary tumour samples from patients with mammary and cervix carcinomas, cells do exhibit a broad distribution of rigidities, with a higher fraction of softer and more contractile cells compared to normal tissue. Mechanical modelling based on patient data reveals that, surprisingly, tumours with a significant fraction of very soft cells can still remain rigid. Moreover, in tissues with the observed distributions of cell stiffnesses, softer cells spontaneously self-organize into lines or streams, possibly facilitating cancer metastasis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Why do rigid tumours contain soft cancer cells?<\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[105],"class_list":["post-95885","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-ibec-seminar","cat_ibec-seminar"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IBEC Seminar: Josef A. K\u00e4s - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/event\/ibec-seminar-josef-a-kas-2\/?lang=eshumanresourcesstrategycalendarcalendarcalendarcalendar\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IBEC Seminar: Josef A. 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