Workshop 2. NET-RARE: Humanized Models for Studying Rare Diseases
Divendres, juliol 4 @ 9:30 am–1:30 pm
NET-RARE second workshop will explore how humanized and bioengineered models can replace 2D cultures and murine models to better understand and replicate rare disorders. The goal is to examine the latest approaches for studying rare diseases in personalized human models.
The opening seminar will feature Juanma Fernández (IBEC). He will present a 3D model designed to study various muscular diseases, along with Organ-on-Chip (OOC) technology and a biosensor platform for detecting biomarkers of the pathology. Next, Anna Collado Gimbert (VHIR) will introduce their new personalized model for studying rare anaemia disorders. Her team, in collaboration with IBEC, has developed a spleen-like microfluidic filtering unit to model disease progression and create a diagnostic device for prognosis and patient stratification.
Following this, international speaker Francesco Saverio Tedesco (University College London) will present his research on enhancing muscle regeneration to develop treatments for severe and incurable childhood diseases, like muscular dystrophies. His team has developed a novel human engineered muscle model for advanced in vitro modelling of muscle disorders involving extracellular matrix, including COL6-related dystrophies.
After a networking break, the next talk will be given by Laura Siles (Instituto de Microcirugía Ocular) in Barcelona. The group develops 3D retina models using induced pluripotent stem (iPS) cells and has extensive expertise in gene editing with CRISPR technology applied to patient-derived iPS cells. Finally, Marc Riu-Villanueva(IBEC) will share their research on neurodegenerative diseases.
Join us to explore the next steps in bioengineering using humanized models to advance biomedical research!
Workshop held in the framework of the IBEC Thematic Networks.
Registration (below) is mandatory.
Scheduled Program:
09:20 – Registration
09:30 – Welcome and introduction
09:40 – Juanma Fernández-Costa, IBEC Group “Biosensors for Bioengineering”, “Next-Gen preclinical models: Muscle-on-Chip meets nanoplasmonic biosensors for drug evaluation in muscular dystrophies”
10:10 – National invited speaker: Anna Collado Gimbert from the VHIR group “Childhood Cancer and Blood disorders”, “Deep characterization of red blood cells in sickle cell disease and other rare anemia disorders by microfluidics and machine learning algorithms”
10:40 – International invited speaker: Francesco Saverio Tedesco, professor of Neuromuscular Biology and Regenerative Medicine, Department of Cell and Developmental Biology, University College London (UK), “Advanced in vitro modelling of neuromuscular diseases and therapeutics”
11:30 – Coffee break and Networking
12:00 – National invited speaker: Laura Siles from the Instituto de Microcirugía Ocular (IMO), “Retinal organoids and gene editing in Inherited Retinal Dystrophies: disease modeling using patient-derived iPSCs and potential therapeutic approximation”
12:30 – Marc Riu-Villanueva, IBEC group “Molecular and Cellular Neurobiology”, “Biochemistry and functional analysis of P301L Tau in human brain cortical organoids modelling tauopathies of the FTLD spectrum”
13:00 – Remarks and Closing
To register click here
