Ibec seminar. Dr Remy Chiaffarelli

Tumour progression is driven by metabolic and vascular changes that shape the tumour microenvironment. We developed new hybrid PET/MRI probes to detect and quantify tumour physiology and its compartmentalization, with a focus on extracellular lactate and perfusion. By combining responsive CEST MRI contrast agents with PET-based quantification, these probes provide complementary functional and quantitative information for preclinical metabolic imaging. Our findings demonstrate the value of these approaches for characterising tumour heterogeneity and metabolic dynamics, providing insights into cancer biology and supporting the development of more precise imaging biomarker.