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IBEC Seminar: Irene Lázaro
Wednesday, June 5 @ 4:00 pm–5:00 pm
Enhanced regeneration through in vivo cell reprogramming: lessons from the first decade of research and a success story in the mouse heart
Irene de Lázaro, PhD1,2,3
1 Department of Biomedical Engineering, NYU Tandon School of Engineering, New York University
2 Cardiovascular Research Center, NYU School of Medicine and NYU Langone Health
3 Harvard John A Paulson School of Engineering and Applied Sciences, Harvard University
Our lab designs and deploys bioengineering strategies – including gene therapies and nanomedicines – to reprogram cell identity, differentiation and/or cellular responses in living organisms with the ultimate goal of helping tissues regenerate better. In this seminar, I will share the lessons learned after the first decade of in vivo cellular reprogramming research. Moreover, I will present our most recent data that demonstrates that on and off expression of stemness-related transcription factors induces partial reprogramming of cardiac myocytes to a rejuvenated state. In an age-dependent mouse model of heart failure, reprogramming the biological age of cardiac myocytes to a youthful state resulted in significant improvement of cardiac function.
