Events

“MICROFLUIDIC AND ROBOTIC PLATFORMS FOR TME-FRIENDLY CANCER DRUG EVALUATIONS” Albert Folch, Professor University of Washington, Bioengineering Dept. There is a lack of confidence in present in vitro disease models and drug efficacy tests, as they do not properly recapitulate the dynamic physiology and pathophysiology of the human organism. This challenge is particularly acute in oncology: ... Read more

Modelling optogenetic control of cell contractility Ulrich Schwarz, Heidelberg University Animal cells are highly dynamic and continuously generate force, for example for mechanosensing, cell division, cell migration, morphogenesis and regeneration. Their main force generators are non-muscle myosin II molecular motors that slide actin filaments past one another. We first discuss how myosin II minifilaments dynamically ... Read more

Involucrar als pacients, no és una moda passatjera Begonya Nafria Escalera, Patient Engagement in Research Head of Department at Sant Joan de Déu Chidren’s Hospital (Spain) La recerca i la innovació que respongui a les necessitats dels pacients, requereix involucrar-los en les fases inicials i durant la vida d’un projecte. En aquesta sessió parlarem sobre ... Read more

Mechanochemical feedback in model epithelial tissues Silke Henkes, Leiden Institute of Physics, Leiden University In the development of animals, tissues self-organise starting from a single cell into layers, shapes and patterns. This active mechanical process operates beyond the theoretical framework of reaction-diffusion equations such as Turing patterns. At the same time, combining active driving with ... Read more

Next-generation organoid models for colorectal cancer research Francisco Lorenzo-Martín, University of Salamanca  Three-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of tumor structures. This has enabled better modelling of low-complexity cancer cell behaviors that occur over short periods of time. However, the currently available organoid systems lack ... Read more

A search for the right scientific question: can we fabricate cells and tissues from scratch? Prof. Pierangelo Gobbo, University of Trieste Bottom-up synthetic biology is an emerging research field whose objectives is to design and fabricate existing biological systems from inanimate molecules, materials, and chemical reactions. One of the key biological systems that bottom-up synthetic ... Read more

Nucleolar mechano-adaptation and its role in epithelial homeostasis Monika E. Dolega, Institute for Advanced Biosciences IAB, INSERM U1209, CNRS UMR5309, University Grenoble-Alpes, Grenoble, France   Epithelial tissues experience constant mechanical stimuli tied to normal physiological functions, but how they maintain homeostasis under such dynamic conditions remains unclear. Our previous RNAseq study on in-plane compressed epithelial ... Read more