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by Keyword: Lgr
Gualda, EJ, Abad-Lázaro, A, Altay, G, Castro-Olvera, G, Bernardello, M, Fernández-Majada, V, Martínez, E, Loza-Alvarez, P, (2025). Fast interrogation of intestinal organ-on-chip devices through inverted single-plane illumination microscopy (iSPIM) using an electro-tunable lens Biomedical Optics Express 16, 2020-2032 
We have developed an inverted single-plane illumination microscope adapted for the interrogation of intestinal epithelium organ-on-chip devices. In this kind of system, samples are normally scanned in a slow fashion through motorized stages. Here, we have engineered a faster sample remote focusing scan mode by the use of an electro-tunable lens synchronized with Galvo mirrors, overcoming some limitations of previous systems. In addition, we have also engineered and optimized scaffolds recapitulating the 3D topography of the intestinal epithelium. Finally, we evaluated the performance of the system using fixed and in-vitro intestinal epithelium organ-on-chip devices, demonstrating the possibility of live imaging for several hours without distorting sample evolution.
JTD Keywords: Crypt, Lgr, Light-sheet microscopy, Stem-cells
Rubio-Canalejas, A, Admella, J, Pedraz, L, Torrents, E, (2023). Pseudomonas aeruginosa Nonphosphorylated AlgR Induces Ribonucleotide Reductase Expression under Oxidative Stress Infectious Conditions mSystems 8, e0100522
The emergence of multidrug-resistant bacteria is a serious problem worldwide. Pseudomonas aeruginosa is a pathogen that causes severe infections because it can form a biofilm that protects it from immune system mechanisms such as the production of oxidative stress. Ribonucleotide reductases are essential enzymes which synthesize deoxyribonucleotides used in the replication of DNA.
JTD Keywords: algr, biofilm, galleria mellonella, nrdj, oxidative stress, Gene-expression, Ribonucleotide reductase
