Modelling optogenetic control of cell contractility Ulrich Schwarz, Heidelberg University Animal cells are highly dynamic and continuously generate force, for example for mechanosensing, cell division, cell migration, morphogenesis and regeneration. Their main force generators are non-muscle myosin II molecular motors that slide actin filaments past one another. We first discuss how myosin II minifilaments dynamically ... Read more
Involucrar als pacients, no és una moda passatjera Begonya Nafria Escalera, Patient Engagement in Research Head of Department at Sant Joan de Déu Chidren’s Hospital (Spain) La recerca i la innovació que respongui a les necessitats dels pacients, requereix involucrar-los en les fases inicials i durant la vida d’un projecte. En aquesta sessió parlarem sobre ... Read more
Mechanochemical feedback in model epithelial tissues Silke Henkes, Leiden Institute of Physics, Leiden University In the development of animals, tissues self-organise starting from a single cell into layers, shapes and patterns. This active mechanical process operates beyond the theoretical framework of reaction-diffusion equations such as Turing patterns. At the same time, combining active driving with ... Read more
Next-generation organoid models for colorectal cancer research Francisco Lorenzo-Martín, University of Salamanca Three-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of tumor structures. This has enabled better modelling of low-complexity cancer cell behaviors that occur over short periods of time. However, the currently available organoid systems lack ... Read more
A search for the right scientific question: can we fabricate cells and tissues from scratch? Prof. Pierangelo Gobbo, University of Trieste Bottom-up synthetic biology is an emerging research field whose objectives is to design and fabricate existing biological systems from inanimate molecules, materials, and chemical reactions. One of the key biological systems that bottom-up synthetic ... Read more
Nucleolar mechano-adaptation and its role in epithelial homeostasis Monika E. Dolega, Institute for Advanced Biosciences IAB, INSERM U1209, CNRS UMR5309, University Grenoble-Alpes, Grenoble, France Epithelial tissues experience constant mechanical stimuli tied to normal physiological functions, but how they maintain homeostasis under such dynamic conditions remains unclear. Our previous RNAseq study on in-plane compressed epithelial ... Read more
This third workshop will focus on overcoming therapeutic barriers in CNS disorders, with particular emphasis on delivery strategies, biological interfaces, and translational challenges. Schedule 09:00 – Registration 09:20 – Welcome from Network Coordinator 09:30 – IBEC speaker: Daniel Gonzalez-Carter, Molecular Bionics group Group. “Exploiting the physiology of the BBB to target therapies to the brain.”Daniel ... Read more
Targeting RhoA mechanoactivity rejuvenates aged hematopoietic stem cells M. Carolina Florian, Stem Cell Aging Group, Regenerative Medicine Program, The Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain. Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR, Barcelona, Spain The Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain Mechanical ... Read more
Join us for the fourth NET-CNS Workshop on April 10th! This fourth NET-CNS workshop will focus on innovative experimental platforms and technologies to model central nervous system (CNS) processes and diseases. Particular emphasis will be placed on advanced in vitro systems, translational research tools, and emerging technologies that enable more physiologically relevant models for studying ... Read more
Developing Nanomedicines Using the Zebrafish Embryo Dr. Federico Fenaroli, University of Stavanger, Norwey Our research focuses on the development of nanomedicines to combat bacterial infections and cancer. We investigate the dynamic in vivo interactions between nanoparticles, immune cells, and pathogenic bacteria or cancer cells. Thanks to their natural transparency, zebrafish embryos enable high-resolution imaging and ... Read more