IBEC Seminar

Steering Self-organization in Active Colloids and Droplets through Confinement Confinement, whether externally imposed or generated by the system itself, plays a central role in shaping the dynamics and self-organization of active matter. In natural systems, such as microbial communities and social insects, self-reinforced confinement is exploited to create functional structures and accomplish complex collective tasks. In contrast, the potential of such mechanisms ... Read more

Nuclear Envelope Remodelling under Mechanical Perturbation Margherita Gallano, predoctoral researcher in the Cellular and Molecular Mechanobiology Group Cells experience mechanical loads during many fundamental processes, including growth, differentiation, and migration. These forces are transmitted to the nucleus and can influence gene expression, ultimately modulating cell behaviour and determining cell fate. The Nuclear Envelope (NE) plays ... Read more

Epigenomic Control of Pancreatic β-Cell Development and Fate: Toward Engineering a Vascularized Organoid-on-Chip Platform Santiago A. Rodríguez-Seguí1,2 1 Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina. 2 Departamento de Fisiología, Biología Molecular y Celular, Universidad de Buenos Aires, Facultad de Ciencias Exactas ... Read more

The p53 pathway and metabolism: implications in normal tissue homeostasis, aging and cancer progression Dr. Le Cam , Montpellier Cancer Research Institute (IRCM) Mutation of the TP53 gene is the most frequent genetic alteration in human cancers. Tumor suppressive functions of p53 have been linked to its ability to control cell division, cell death and ... Read more

Bioactives Beyond Screening: From Molecular Potential to Local Gut Function Bioactive molecules are often selected through simplified screening assays, where antioxidant, antimicrobial, anti-inflammatory or cytotoxic responses provide an initial indication of biological potential. However, in the gastrointestinal context, this potential can be profoundly reshaped by digestion, solubility, mucus, microbiota metabolism, epithelial interactions and the local ... Read more

Hybrid PET/MR Imaging of Tumour Physiology: from Perfusion to Extracellular Lactate Dr Remy Chiaffarelli, Eberhard Karls University Tübingen Tumour progression is driven by metabolic and vascular changes that shape the tumour microenvironment. We developed new hybrid PET/MRI probes to detect and quantify tumour physiology and its compartmentalization, with a focus on extracellular lactate and perfusion. ... Read more

Ways of Seeing  Nature is a master designer, shaping molecules, materials, organisms, and ecosystems through interactions across scales. Yet many of its most remarkable strategies remain hidden in plain sight, waiting to be revealed through careful observation. Scientific discovery often begins not with a hypothesis, but with a way of seeing: the ability to notice ... Read more

Constructing Biological Complexity: Engineering Interactions Across Scales Biological systems achieve remarkable functionality through interactions that span multiple scales, from molecular assemblies and cellular compartments to tissues and complex microenvironments. Understanding how these interactions give rise to emergent behaviors is a central challenge in contemporary bioengineering and synthetic biology. This workshop brings together researchers exploring how ... Read more

Nanomed Spain e IBEC organizan esta Jornada Informativa para acercar a la comunidad investigadora y empresarial las principales oportunidades de financiación para proyectos de I+D+i en salud. A través de las intervenciones de representantes del CDTI y de la Fundación Científica de la AECC, la jornada presentará las próximas convocatorias del programa Horizonte Europa, los instrumentos nacionales de apoyo a ... Read more

Multiscale dynamics and mechanics of the basement membrane in epithelial morphogenesis Hironobu Fujiwara, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan The basement membrane (BM) is a highly organized extracellular matrix that underlies or surrounds most tissues, providing mechanical and biochemical cues. How the BM dynamically remodels during tissue morphogenesis remains poorly understood. By ... Read more