IBEC Seminar

Nuclear mechanobiology – from striated muscle disease to ultrarapid cellular mechanosensing Jan Lammerding, PhD, Weill Institute for Cell and Molecular Biology & Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA Abstract. The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is investigating ... Read more

Developability assessment of biologics and formulation of novel molecules Shahid Uddin, PhD, MBA, Senior Director of Drug Product, Formulation & Stability within the CMC department at Immunocore, UK It’s vital to ensure appropriate assessment of molecules at the early research phase is carried out to risk mitigate movement into the development phase. This ensures the best risk ... Read more

Nanomedicine to Tackle Unmet Medical Needs in CNS Disorders Sabina Quader, Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821 Japan The brain is undoubtedly the body's most essential and intricate organ, and brain disorders are closely tied to this intricacy. Categorized as "CNS diseases," a wide range of brain-related conditions - ... Read more

Semi-synthetic nucleosomes to stabilize and image enzyme-chromatin interactions Carlos Moreno Yruela, Researcher in Chemical Biology, EPFL, Switzerland Chromatin structure regulates gene expression and is tightly controlled by histone post-translational modifications. SIRT7 is a histone lysine deacylase found to maintain oncogenic gene expression profiles supporting tumor growth and metastasis. Interestingly, the activity of SIRT7 is fully ... Read more

Harnessing the power of stem cell therapy in an off-the-shelf nano-delivery platform for treating brain disorders Prof Marcelle Machluf, Faculty of Biotechnology and Food Engineering, Technion, Haifa, Israel Mesenchymal stem cells (MSCs) have gained the most attention in cell therapy, owing to their ability to traverse physiological barriers, and target different sites of inflammation including ... Read more

Advances in understanding and manipulating influenza A virus liquid inclusions Maria João Amorim, PhD, Group Leader, Cell Biology of Viral Infection Lab, Católica Biomedical Research Centre, Universidade Católica Portuguesa, and Instituto Gulbenkian de Ciência, Portugal Many viruses form biomolecular condensates de novo as part of their replication programmes. Influenza A virus is an important human pathogen ... Read more

3D architecture and mechanism of touch detection in the Pacinian corpuscle Slav Bagriantsev, Associate Professor of Cellular & Molecular Physiology, Yale School of Medicine, USA Pacinian corpuscles are specialized mechanoreceptor end-organs that detect transient touch and high-frequency vibration in the skin and viscera of many vertebrates. Corpuscles have a complex cellular organization, which includes a ... Read more

Mechanical imprints of cell fate and cell competition Benoît Ladoux, Institut Jacques Monot (IJM) Paris Epithelia are communities of cells with close intercellular communications and of highly ordered coordination in their motion. Mechanical properties of epithelial tissues are important for our understanding of many vital biological processes, including homeostasis, morphogenesis, and metastasis and are tightly ... Read more

Translating fear mechanisms between humans and mice Raül Andero Galí, PhD, ICREA Research Professor at the Institute of Neurosciences of the Autonomous University of Barcelona Sex-specific mechanisms in fear memory and extinction may explain certain neuropsychiatric disorders like Post-Traumatic Stress Disorder (PTSD). In male mice, chemogenetic silencing of centromedial amygdala (CeM)-Tac2 fibers in the lateral ... Read more

Beyond NGS: A toolbox for single-molecule epigenetic analysis of DNA Prof. Yuval Ebenstein, Department of Physical Chemistry, Department of Biomedical Engineering, Founder, Innovation and Entrepreneurship Center Tel Aviv University, Israel. DNA sequencing (NGS) is revolutionizing all fields of biological research. Still, it fails to extract the full range of information associated with genetic material and ... Read more