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Nuclear Envelope Remodelling under Mechanical Perturbation Margherita Gallano, predoctoral researcher in the Cellular and Molecular Mechanobiology Group Cells experience mechanical loads during many fundamental processes, including growth, differentiation, and migration. These forces are transmitted to the nucleus and can influence gene expression, ultimately modulating cell behaviour and determining cell fate. The Nuclear Envelope (NE) plays ... Read more |
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Epigenomic Control of Pancreatic β-Cell Development and Fate: Toward Engineering a Vascularized Organoid-on-Chip Platform Santiago A. Rodríguez-Seguí1,2 1 Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina. 2 Departamento de Fisiología, Biología Molecular y Celular, Universidad de Buenos Aires, Facultad de Ciencias Exactas ... Read more
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The p53 pathway and metabolism: implications in normal tissue homeostasis, aging and cancer progression Dr. Le Cam , Montpellier Cancer Research Institute (IRCM) Mutation of the TP53 gene is the most frequent genetic alteration in human cancers. Tumor suppressive functions of p53 have been linked to its ability to control cell division, cell death and ... Read more |
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Bioactives Beyond Screening: From Molecular Potential to Local Gut Function Bioactive molecules are often selected through simplified screening assays, where antioxidant, antimicrobial, anti-inflammatory or cytotoxic responses provide an initial indication of biological potential. However, in the gastrointestinal context, this potential can be profoundly reshaped by digestion, solubility, mucus, microbiota metabolism, epithelial interactions and the local ... Read more |
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Hybrid PET/MR Imaging of Tumour Physiology: from Perfusion to Extracellular Lactate Dr Remy Chiaffarelli, Eberhard Karls University Tübingen Tumour progression is driven by metabolic and vascular changes that shape the tumour microenvironment. We developed new hybrid PET/MRI probes to detect and quantify tumour physiology and its compartmentalization, with a focus on extracellular lactate and perfusion. ... Read more |
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