Towards an evolutionary-driven universal therapy against (intracellular) pathogens Università degli Studi di Milano We are living a time where we believe antibiotics are the cornerstone of any infectious disease-based therapy. It is definitely out of question that antibiotics saved millions of people worldwide in the last century, and that they are still doing it very ... Read more

Building tissues to understand how tissues build themselves Zev Gartner, UCSF Cells assemble into tissues and organs through an active process termed self-organization. Harnessing tissue self-organization will ultimately advance applications as diverse as disease modeling and regenerative medicine, while revealing new strategies for fighting disease. However, progress towards these applications is limited by our incomplete ... Read more

Organ on a chip models to emulate multi systemic metabolic diseases Javier Ramon, IBEC Existing on-chip tissue models typically represent a single organ, limiting systemic drug investigations. Microscale tissue analog systems aim to improve drug and toxicity predictions across various organs. However, multi-organ devices are limited, and none have explored skeletal muscle and pancreatic islets. ... Read more

Translation and Initial Patient and Volunteer Studies with Hyperpolarized Carbon-13 MR Molecular Imaging Dan Vigneron, Department of Radiology & Biomedical Imaging, University of California San Francisco "Hyperpolarized (HP) carbon-13 MRI is an emerging molecular imaging method to monitor enzymatic conversions through key, previously-inaccessible biochemical pathways. Over 1000 human HP carbon-13 MR studies to date have ... Read more

Awake brain surgery mapping - a way to mitigate postsurgical impairments and a door to understanding human cognition MDr Joanna Sierpowska from the Department of Cognition, Development and Educational Psychology, Institute of Neurosciences, University of Barcelona Brain mapping for language and cognition during awake brain surgeries helps neurosurgeons to mitigate postsurgical impairments. At the same ... Read more

Highlights of 20 years DNP with Merck as partner Matthias Schulze, Merck Introduction of Merck’s capabilities to supply specifically labeled tracers in different grades. Describing the milestones of DNP towards establishing that method as a powerful tool in cancer diagnostics. Outlining the challenges and the scope on projects utilizing 13 C labeled reagents. Matthias Schulze ... Read more

Reprogramming the Factory of Life to Target the Delivery of mRNA via Helical Chirality Virgil Percec, Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia Homochiral helical self-organizations are known at the macroscopic level in nature, art, architecture and science for thousands of years . However, molecular helicity was discovered in proteins ... Read more