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Staff member

Rosalba Sortino

Nanoprobes and Nanoswitches
+34 934037626
Staff member publications

Sortino, Rosalba, González-Díez, Aleix, Milla-Navarro, Santiago, Martínez-Tambella, Joaquín, Paleo-García, Víctor, Calatayud, Eric, de Saralegui, Paula, Opar, Ekin, Claparols, Àlvar, Quintanilla, Josecarlo A., Martínez-Soler, Xavier, Riefolo, Fabio, Matera, Carlo, Hernando, Jordi, Gomila, Alexandre MJ., Pérez-Batlle, Gerard, Pereira, Carles, Camarero, Núria, Serra, Carme, Gómez-Santacana, Xavier, Llebaria, Amadeu, Rovira, Xavier, de la Villa, Pedro, Gorostiza, Pau, (2026). Restoration of Saccadic Eye Movements and Visually Guided Behavior in Ambient White Light with Photoswitchable Small Molecules JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ,

Papotto, Claudio, Pérez-Pérez, Nayeli Fernanda, Gomila, Alexandre M.J., Sortino, Rosalba, Cases, Mercè, Lee, Hyojung, Calzaferri, Francesco, De Amici, Marco, Dallanoce, Clelia, Gorostiza, Pau, Matera, Carlo, (2026). Photocontrol of zebrafish behavior with a photoswitchable ligand of nicotinic acetylcholine receptors BIOMEDICINE & PHARMACOTHERAPY 201, 119727

Prischich, Davia, Sortino, Rosalba, Gomila-Juaneda, Alexandre, Matera, Carlo, Guardiola, Salvador, Nepomuceno, Diane, Varese, Monica, Bonaventure, Pascal, de Lecea, Luis, Giralt, Ernest, Gorostiza, Pau, (2024). In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B CELLULAR AND MOLECULAR LIFE SCIENCES 81, 288

Gorostiza, Pau

JTD

Riefolo, F., Matera, C., Garrido-Charles, A., Gomila, A., Sortino, R., Agnetta, L., Claro, E., Masgrau, R., Holzgrabe, U., Batlle, M., Decker, M., Guasch, E., Gorostiza, P., (2019). Optical control of cardiac function with a photoswitchable muscarinic agonist Journal of the American Chemical Society 141, (18), 7628-7636

Light-triggered reversible modulation of physiological functions offers the promise of enabling on-demand spatiotemporally controlled therapeutic interventions. Optogenetics has been successfully implemented in the heart, but significant barriers to its use in the clinic remain, such as the need for genetic transfection. Herein, we present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. The molecule, named PAI, was designed by introduction of a photoswitch into the molecular structure of an M2 mAChR agonist. In vitro assays revealed that PAI enables light-dependent activation of M2 mAChRs. To validate the method, we show that PAI photoisomers display different cardiac effects in a mammalian animal model, and demonstrate reversible, real-time photocontrol of cardiac function in translucent wildtype tadpoles. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light, which overcomes the scattering and low penetration of short-wave-length illumination, and offers new opportunities for intravital imaging and control of cardiac function.

JTD