Nanomalaria joint unit seminar: Konstantinos Mitsakakis, University of Freiburg

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LabDisk, a multi-purpose, multi-target diagnostic platform for patient management and surveillance at the point-of-care

Dr. Konstantinos Mitsakakis, Hahn-Schickard & IMTEK, Department of Microsystems Engineering, University of Freiburg, Germany

The LabDisk is a CD-shaped microfluidic platform with all reagents integrated for on-site sample-to-answer diagnosis of single or multiple infectious diseases stemming from parasites, bacteria, viruses, or co-infections of theirs. Through “composite” diagnosis, by combining molecular diagnostics and protein biomarker detection, the LabDisk offers increased reliability in pathogen species identification. Its modular nature enables the creation of a “disc library” for different sample matrices, and the rapid adaptation to end-users’ requests (endemic needs, sudden epidemics outbreaks). The presentation will consist of two sections: (1) description of the LabDisk and its operating principle (modularity, multiplexity, fully integrated sample preparation); and (2) an overview of the current infectious disease-related applications, in particular: neonatal sepsis, respiratory tract infections, antibiotic resistance, febrile tropical infections (malaria, dengue, pneumonia, typhoid), mosquito/vector control. Dr. Mitsakakis has been invited by Xavier Fernàndez Busquets, Head of Nanomalaria Joint Unit