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IBEC Seminar (Bellvitge): Martin Lohse, University of Würzburg
Friday, January 22, 2016 @ 3:00 pm–4:00 pm
Optical studies of receptor activation and signaling
Prof. Dr. Martin Lohse, Chairman of the Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, GermanyCyclic nucleotides (cAMP and cGMP) belong to the most ubiquitous intracellular messengers, are produced in response to multiple stimuli, act on several intracellular targets, and regulate a vast array of biological functions.
However, in spite of the fundamental importance of these signaling systems, very little is known about the temporal and spatial patterns of their production and action. In fact, space and time seem to play almost no role in current concepts of intracellular signaling. To gain an insight into these dimensions, we develop methods to create images of these second messengers in intact cells, and to resolve these intracellular signals in space and in time.
