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IBEC Seminar: Danny Hatters
Tuesday, June 6 @ 9:30 am–11:00 am
Protein interactions gone awry in neurodegenerative disease
Danny Hatters, Department of Biochemistry and Pharmacology | Faculty of Medicine, Dentistry and Health Sciences
The University of Melbourne, Australia
The Hatters lab studies impacts of protein misfolding and aggregation in cultured cell models of neurodegenerative diseases. We have developed approaches to examine principles governing how proteins inappropriately aggregate and new approaches with chemical reagents to monitor cysteine reactivity to probe changes in proteome foldedness and conformation. I will discuss recent findings from our laboratory that provide insight to the consequences of protein aggregation by globular proteins, and how we can model the types of protein-protein interactions that are involved. I will also discuss how we can monitor changes in protein structure and function in response to stresses and stimuli, and under conditions of disease in Huntington Disease.