Linking cell adhesion receptors with the cytoskeleton in morphogenesis
Prof. Nick Brown, Dept of Physiology, Development and Neuroscience, University of Cambridge
We use Drosophila development as our test tube to dissect mechanisms of integrin-mediated adhesion to the extracellular matrix, tackling these questions:
-How is the adhesion structure built?
-What are the roles of the many adhesome components?
-How did the integrin machinery arise during evolution?
-Can we establish an integrated model of integrin adhesion sites?