CV SummaryBenedetta Bolognesi was a graduate student in the Department of Chemistry at the University of Cambridge (UK) under the supervision of Prof. Chris Dobson. There, her work focused on the intrinsic determinants of aggregation and toxicity of the amyloid-beta peptide. Then, she moved to the Centre for Genomic Regulation (Barcelona, Spain) with an interdisciplinary Marie Curie fellowship to elucidate the mechanisms underlying dosage sensitivity in yeast. Towards the end of her post-doc she developed a deep mutational scanning (DMS) strategy to quantify the effect of thousands of mutations in disordered protein domains. That is what got her into DMS - an approach she and her team use now in the lab to answer a wide range of biological questions, with a particular focus on proteins that form liquid condensates and amyloids.
Staff member publications
Seuma M, Bolognesi B, (2022). Understanding and evolving prions by yeast multiplexed assays Current Opinion In Genetics & Development 75, 101941
Marte L, Boronat S, Barrios R, Barcons-Simon A, Bolognesi B, Cabrera M, Ayté J, Hidalgo E, (2022). Expression of Huntingtin and TDP-43 Derivatives in Fission Yeast Can Cause Both Beneficial and Toxic Effects International Journal Of Molecular Sciences 23, 3950
Badia M, Bolognesi B, (2021). Assembling the right type of switch: Protein condensation to signal cell death Current Opinion In Cell Biology 69, 55-61
Seuma, M, Faure, AJ, Badia, M, Lehner, B, Bolognesi, B, (2021). The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations Elife 10, e63364
Bolognesi, Benedetta, Faure, Andre J., Seuma, Mireia, Schmiedel, Jörrn M., Tartaglia, Gian Gaetano, Lehner, Ben, (2019). The mutational landscape of a prion-like domain Nature Communications 10, (1), 4162
Bolognesi, Benedetta, Lehner, Ben, (2018). Reaching the limit eLife 7, e39804