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by Keyword: Integrin alpha 5 beta 1
Wang, Xinru, Guillem-Marti, Jordi, Kumar, Saurav, Lee, David S, Cabrerizo-Aguado, Daniel, Werther, Rachel, Alamo, Kevin Alexander Estrada, Zhao, Yan Ting, Nguyen, Adam, Kopyeva, Irina, Huang, Buwei, Li, Jing, Hao, Yuxin, Li, Xinting, Brizuela-Velasco, Aritza, Murray, Analisa, Gerben, Stacey, Roy, Anindya, DeForest, Cole A, Springer, Timothy, Ruohola-Baker, Hannele, Cooper, Jonathan A, Campbell, Melody G, Manero, Jose Maria, Ginebra, Maria-Pau, Baker, David, (2025). De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties ADVANCED MATERIALS 37, 2500872 
Integrin alpha 5 beta 1 is crucial for cell attachment and migration in development and tissue regeneration, and alpha 5 beta 1 binding proteins can have considerable utility in regenerative medicine and next-generation therapeutics. We use computational protein design to create de novo alpha 5 beta 1-specific modulating miniprotein binders, called NeoNectins, that bind to and stabilize the open state of alpha 5 beta 1. When immobilized onto titanium surfaces and throughout 3D hydrogels, the NeoNectins outperform native fibronectin (FN) and RGD peptides in enhancing cell attachment and spreading, and NeoNectin-grafted titanium implants outperformed FN- and RGD-grafted implants in animal models in promoting tissue integration and bone growth. NeoNectins should be broadly applicable for tissue engineering and biomedicine.
JTD Keywords: Activation, Alpha(5)beta(1), Biomaterial, Cell, De novo protein design, Differentiation, Fibronectin, Growth-factor-beta, Hydrogel, In-vivo, Integrin alpha 5 beta 1, Ligan, Microscopy, Migration, Regenerative medicine, Rgd, Titaniu
