Assessment of trunk function in patients with spinal cord injury using electromyography and smartphone accelerometry Yolanda Castillo, Biomedical Signal Processing and Interpretation Spinal cord injury (SCI) causes motor and sensory impairment below the level of the injury, but also many other health problems. A common consequence of SCI is the lack of control over trunk ... Read more
Investigating Pathological Extracellular Matrix Architecture The composition and architecture of the extracellular matrix (ECM), and their dynamic alterations, play an important regulatory role on numerous cellular processes. Furthermore, structural and biochemical properties of the ECM are central in regulating cell behavior via mechanical, chemical and topological cues detected by receptors in the cell membrane which ... Read more
Biomechanics of the progression of colorectal carcinomas Giulia Fornabaio, Synthetic morphogenesis group According to the World Health Organization, cancer is one of the main causes of death worldwide, with colorectal carcinoma (CRC) being the second-leading cause of tumour related-death. The high rate of mortality of CRCs is principally attributed to the metastasis of neoplastic cells ... Read more
Mechanical phenotyping of colorectal cancer patient derived organoids based on LGR5 expression Sefora Conti, Integrative cell and tissue dynamics group Colorectal cancer (CRC) tumors are composed by heterogeneous cell populations comprising differentiated cells and a small pool of cancer stem cells (CSCs). The link between cancer cell differentiation states and their metastatic potential has been ... Read more
Mechanical phenotyping of colorectal cancer patient derived organoids based on LGR5 expression Sefora Conti, Integrative cell and tissue dynamics group Colorectal cancer (CRC) tumors are composed by heterogeneous cell populations comprising differentiated cells and a small pool of cancer stem cells (CSCs). The link between cancer cell differentiation states and their metastatic potential has been ... Read more
Mechanical phenotyping of colorectal cancer patient derived organoids based on LGR5 expression Sefora Conti, Integrative cell and tissue dynamics group Colorectal cancer (CRC) tumors are composed by heterogeneous cell populations comprising differentiated cells and a small pool of cancer stem cells (CSCs). The link between cancer cell differentiation states and their metastatic potential has been ... Read more
Mechanical characterization of murine pluripotency dissolution Srivatsava Viswanadha Venkata Naga Sai, Cellular and Molecular Mechanobiology Group Mouse Embryonic Stem Cells (mESCs) can be maintained in ground/naïve state when grown in a defined N2B27 media with the supplementation of two inhibitors (2i) for MEK/Erk and GSK3β. Upon 2i withdrawal, mESCs exit naïve state and become functionally ... Read more
Mechanical characterization of murine pluripotency dissolution Srivatsava Viswanadha Venkata Naga Sai, Cellular and Molecular Mechanobiology Group Mouse Embryonic Stem Cells (mESCs) can be maintained in ground/naïve state when grown in a defined N2B27 media with the supplementation of two inhibitors (2i) for MEK/Erk and GSK3β. Upon 2i withdrawal, mESCs exit naïve state and become functionally ... Read more
Novel Nuclear Magnetic Resonance (NMR) applications in the clinical field Marc Azagra, Molecular Imaging for Precision Medicine Group When nuclear magnetic resonance (NMR) was described more than half a century ago it appeared to be a curiosity of the quantum world. Since then NMR spectroscopy has become an essential tool not only for chemists, but also ... Read more
Novel Nuclear Magnetic Resonance (NMR) applications in the clinical field Marc Azagra, Molecular Imaging for Precision Medicine Group When nuclear magnetic resonance (NMR) was described more than half a century ago it appeared to be a curiosity of the quantum world. Since then NMR spectroscopy has become an essential tool not only for chemists, but also ... Read more