Molecular Imaging for Precision Medicine

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The central theme of our work is the development of new insight and applications in chemical biology systems.

Our group’s research line is to detect, identify and validate biomarkers of disease. In particular, we focus on developing molecular imaging tools to identify abnormalities of cell metabolism in human disease and predict treatment efficacy.

In particular, we focus on Bioengineering solutions using Chemistry and Physics tools to study Biological problems. Specifically, we develop Magnetic Resonance (MR) molecular imaging methods to study the biochemical pathways in bioengineered systems and in vivo.

MR is already a well-known clinical technique in the form of 3D, non–destructive imaging of tissue and fluid composition in vivo (MRI). As a further benefit, MR spectroscopic imaging is chemically specific and can thus directly relate response of a single (or many) chemical compound to biological events in biofluids, cell suspensions in vitro, excised tissue and perfused organs ex vivo, animal models in vivo and clinical patients. The rich variety of MR experiments developed over the past decades permits quantification of metabolites concentrations, diffusion rates, perfusion, energetics and tissue oxygenation. These parameters represent a steady state fingerprint of the sample studied, which encodes physiological and pathological factors.

Our young team of passionate researchers works at the forefront of molecular imaging using a technique known as hyperpolarised MR (HP-MR), which increases the signal of MR more than 10.000 times. This dramatic increase means that we can now see molecular processes in real time, in situ, and non-invasively in a wide range of biological systems.





Irene Marco Rius | Junior Group Leader
Gerardo López Muñoz | Postdoctoral Researcher
Marc Azagra Rodríguez | PhD Student
Alba Herrero Gómez | Laboratory Technician





Project Financer Subprogram IP
Analisis metabolico en tiempo real de modelos de cultivo de celulas 3d de la enfermedad del higado graso no alcoholico: organos en un chip y resonancia magnetica nuclear (2020-2021) MINECO Acciones Dinamización Europa Investigación/EIN2020-112209 Irene Marco



Trueba-Santiso, A., Fernández-Verdejo, D., Marco Rius, I., Soder-Walz, J. M., Casabella, O., Vicent, T., Marco-Urrea, E., (2020). Interspecies interaction and effect of co-contaminants in an anaerobic dichloromethane-degrading culture Chemosphere 240, 124877

An anaerobic stable mixed culture dominated by bacteria belonging to the genera Dehalobacterium, Acetobacterium, Desulfovibrio, and Wolinella was used as a model to study the microbial interactions during DCM degradation. Physiological studies indicated that DCM was degraded in this mixed culture at least in a three-step process: i) fermentation of DCM to acetate and formate, ii) formate oxidation to CO2 and H2, and iii) H2/CO2 reductive acetogenesis. The 16S rRNA gene sequencing of cultures enriched with formate or H2 showed that Desulfovibrio was the dominant population followed by Acetobacterium, but sequences representing Dehalobacterium were only present in cultures amended with DCM. Nuclear magnetic resonance analyses confirmed that acetate produced from 13C-labelled DCM was marked at the methyl ([2–13C]acetate), carboxyl ([1–13C]acetate), and both ([1,2–13C]acetate) positions, which is in accordance to acetate formed by both direct DCM fermentation and H2/CO2 acetogenesis. The inhibitory effect of ten different co-contaminants frequently detected in groundwaters on DCM degradation was also investigated. Complete inhibition of DCM degradation was observed when chloroform, perfluorooctanesulfonic acid, and diuron were added at 838, 400, and 107 μM, respectively. However, the inhibited cultures recovered the DCM degradation capability when transferred to fresh medium without co-contaminants. Findings derived from this work are of significant relevance to provide a better understanding of the synergistic interactions among bacteria to accomplish DCM degradation as well as to predict the effect of co-contaminants during anaerobic DCM bioremediation in groundwater. © 2019 Elsevier Ltd

Keywords: Bioremediation, Co-contaminants, Dehalobacterium, Dichloromethane, Inhibition




El nou programa Fundació “la Caixa” – BIST Chemical Biology impulsa un hub per al disseny de nous fàrmacs a Barcelona

La Fundació “la Caixa” i el BIST creen el programa Chemical Biology per impulsar dos nous grups de recerca puntera a l’IBEC i a l´IRB, dos centres membres del BIST. La iniciativa pretén captar talent en l’àmbit de la biologia química i alhora promoure la creació d’un ecosistema que fomenti la investigació d’excel·lència per millorar la salut de les persones.

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