- Aquest esdeveniment ja ha passat.
IBEC Seminar: Prof. Yuval Ebenstein
Dimarts, desembre 17 @ 3:00 pm–4:00 pm
Beyond NGS: A toolbox for single-molecule epigenetic analysis of DNA
Prof. Yuval Ebenstein, Department of Physical Chemistry, Department of Biomedical Engineering, Founder, Innovation and Entrepreneurship Center Tel Aviv University, Israel.
DNA sequencing (NGS) is revolutionizing all fields of biological research. Still, it fails to extract the full range of information associated with genetic material and cannot resolve important variations between genomes. The information content of the genome extends beyond the base sequence in the form of chemical modifications such as DNA methylation or chromosomal association with DNA-binding proteins (chromatin). For the last decade, my lab has been developing tools for genomic analysis at the single-cell and single-molecule levels. I will show how the physical extension of long DNA molecules in nanofluidic channels reveals this information in the form of a linear, optical, or electrical “barcode,” like beads threaded on a string, where each bead represents a distinct type of observable. I’ll present a biochemical and physical toolbox for mapping epigenetic modifications in the genome and demonstrate its application in clinical cancer research. Finally, I will talk about a DNA chip developed in the lab and the adventure of building a startup based on this technology.
Short Bio:
Prof. Yuval Ebenstein is a scientist and entrepreneur with years of experience in translational research. Yuval is head of the NanoBioPhotonix Lab and the founder of the Tel Aviv University Entrepreneurship Center. In his lab, Yuval combines Chemistry, Physics, Biology, and bioinformatics in order to study the human genome. His lab explores genomes utilizing tools and reagents from the realm of nano-technology, zooming in on single cells, single chromosomes, and single molecules. Yuval is the winner of two ERC awards for developing genomic technologies and is the founder of JaxBio, a liquid biopsy methylation-based diagnostics startup.
