by Keyword: By-product valorisation
Rached, Rita Abi, Shakya, Ashok K, Fulgheri, Federica, Aroffu, Matteo, Castangia, Ines, Garcia-Villen, Fatima, Ferraro, Maria, Fernandez-Busquets, Xavier, Pedraz, Jose Luis, Louka, Nicolas, Maroun, Richard G, Manconi, Maria, Manca, Maria Letizia, (2025). Resveratrol and grape pomace extract incorporated in modified phospholipid vesicles: A potential strategy to mitigate cigarette smoke-induced oxidative stress Free Radical Biology And Medicine 230, 151-162
In this study, the extraction process of grape pomace from the Lebanese autochthonous cultivar Asswad Karech was enhanced through the selection of specific parameters, yielding an antioxidant extract (20 mg/mL) that was co-loaded with resveratrol (5 mg/mL) into phospholipid vesicles containing penetration enhancers (PEVs). Propylene glycol (PG) was incorporated as a penetration enhancer at concentrations of 10, 20, and 30 % to obtain 10 PG-PEVs, 20 PG-PEVs, and 30 PG-PEVs. Vesicle preparation was achieved through direct sonication, yielding unilamellar and bilamellar vesicles with an average size of similar to 205; 234 nm, a monodisperse distribution (polydispersity index
JTD Keywords: By-product valorisation, Cigarette smoke, Delivery, Dru, Grape pomace extract, In-vitro, Liposomes, Lung deliver, Oxidative stress, Phospholipids vesicles
