by Keyword: Hexanucleotide repeat
Garcia-Guerra, A, Ellerington, R, Gaitzsch, J, Bath, J, Kye, M, Varela, MA, Battaglia, G, Wood, MJA, Manzano, R, Rinaldi, C, Turberfield, AJ, (2023). A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles Nanoscale Advances 5, 2941-2949
Polymeric spherical nucleic acids comprise pH-sensitive, polymer-conjugated oligonucleotides that self-assemble into nanoparticles with the ability to escape endosomes, overcoming a major obstacle in nucleic acid delivery.
JTD Keywords: c9orf72, cellular uptake, dna, encapsulation, expansion, ph, stability, trafficking, vesicles, Hexanucleotide repeat